Factors associated with decreasing serum 25(OH)D among Japanese patients with rheumatoid arthritis: Results from the IORRA cohort study

Nakayama, Masanori; Furuya, Takefumi; Inoue, Eisuke; Tanaka, Eiichi; Ikari, Katsunori; Nakajima, Ayako; Taniguchi, Atsuo; Yamanaka, Hisashi

doi:10.1080/14397595.2018.1481727

Cited by 7 publications

(2 citation statements)

References 24 publications

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“…The IORRA cohort was established in October 2000 as a single, institute-based, large, observational cohort of Japanese patients with RA at the Institute of Rheumatology, Tokyo Women’s Medical University. Details regarding the purpose and methodology of this study have been reported previously [ [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] ]. Over 139 publications have described various characteristics of Japanese patients with RA from this large cohort.…”

Section: Methodsmentioning

confidence: 99%

“…Previously, we have reported various clinical characteristics of osteoporosis in Japanese patients with RA by way of utilizing data from our Institute of Rheumatology Rheumatoid Arthritis (IORRA) cohort study [ [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] ]. For patients with RA, the prevention of fractures is important to the maintenance of their quality of life (QoL), thus their osteoporosis requires appropriate treatment.…”

Section: Introductionmentioning

confidence: 99%

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Factors associated with osteoporosis medication use in Japanese patients with rheumatoid arthritis: Results from the Institute of Rheumatology Rheumatoid Arthritis cohort study

Nakayama

Furuya

Inoue

et al. 2020

Osteoporosis and Sarcopenia

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Objectives This study aimed to evaluate factors associated with osteoporosis medication use in Japanese patients with rheumatoid arthritis (RA). Methods Patients with RA who enrolled in our cohort completed self-administered questionnaires which included questions regarding their osteoporosis medications. Logistic regression was used to determine the association of variables with the use of these medications. Results Among 5660 Japanese patients with RA who responded to the questionnaires (mean age, 61.8 years; 86.0% female), 1983 patients (35.0%) and 1211 patients (21.4%) reported taking osteoporosis medications and antiresorptive agents, respectively. In multivariate models, age, female sex, lower body mass index (BMI), self-reported fracture history, Japanese Health Assessment Questionnaire-Disability Index (JHAQ-DI), daily dosage of prednisone (PSL), weekly dosage of methotrexate (MTX), and concomitant use of hypertension and hyperlipidemia medications were significantly associated with the use of osteoporosis medications (P < 0.05). Among women with RA, the use of hypertension medications was significantly correlated with the use of both osteoporosis medications and antiresorptive agents (P < 0.05). Conclusions Age, female sex, a lower BMI, duration of RA, self-reported fracture history, JHAQ-DI, daily dosage of PSL, weekly dosage of MTX, and the use of medications for hypertension and hyperlipidemia appear to be associated with the use of osteoporosis medications in Japanese patients with RA.

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