Factors associated with carotid intima media thickness in South African children with chronic kidney disease

Mudi, Abdullahi; Holland, Zaiboonisa; Dickens, Caroline; Ballot, Daynia; Levy, Cecil

doi:10.5414/cn109791

Cited by 2 publications

(1 citation statement)

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“…In this context, qualitative and quantitative lipid abnormalities have been reported in these patients (52)(53)(54)(55) and linked to both carotid atherosclerosis (55)(56)(57)(58) and CKD progression (59). Moreover, blood pressure, haemoglobin and several mineral metabolism parameters predict carotid atherosclerosis progression in CKD patients (60,61). Finally, the association between GFR and carotid atherosclerosis is greatly reduced or lost after adjustment for CV risk factors (43,62) and it has been suggested that cIMT can even be comparable between patients with CKD and healthy controls (63).…”

Section: From Carotid Atherosclerosis To Ckd Progression and CV Eventsmentioning

confidence: 99%

Narrative Review of Carotid disease and the kidney

Zanoli

Mikhailidis

2021

Ann Transl Med

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Patients with chronic kidney disease (CKD) have an increased cardiovascular (CV) risk that is only in part explained by established risk factors. Carotid arteriosclerosis and atherosclerosis are increased in CKD, play a role in the causation of CV disease in these patients and can affect the progression of renal disease. The arterial stiffening process is evident even in CKD patients with a very mild reduction of glomerular filtration rate (GFR) whereas arterial thickening is evident in more advanced stages. Possible mechanisms include functional and structural alterations of the arterial wall. Arterial stiffness can mediate the effect of CKD on target organs (i.e., brain, kidney and heart). In this review we discuss the arterial phenotype of patients with CKD. This is characterized by increased common carotid artery stiffness and outward remodeling (enlargement and thickening of the arterial wall) and a normal/reduced stiffness paired with an inward remodeling (narrowing of the arterial wall) of muscular arteries. We also discuss the consequences of carotid dysfunction, including the involvement of large elastic arteries stiffness on ventricular-vascular coupling, the mechanisms linking carotid stiffening and increased cardio-and cerebrovascular risk in CKD patients, and the therapeutic options to improve carotid function.

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Section: From Carotid Atherosclerosis To Ckd Progression and CV Eventsmentioning

confidence: 99%

Narrative Review of Carotid disease and the kidney

Zanoli

Mikhailidis

2021

Ann Transl Med

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Role of klotho and fibroblast growth factor 23 in arterial calcification, thickness, and stiffness: a meta-analysis of observational studies

Wungu,

Susilo,

Alsagaff

et al. 2024

Sci Rep

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This meta-analysis was conducted to clarify the role of klotho and fibroblast growth factor 23 (FGF-23) in human arterial remodeling across recent studies, in terms of arterial calcification, thickness, and stiffness. A systematic literature search was conducted on five databases for articles up to December 2023. Arterial calcification, thickness, and stiffness were determined using the calcification score and artery affected, carotid intima–media thickness (CIMT), and pulse wave velocity (PWV), respectively. Sixty-two studies with a total of 27,459 individuals were included in this meta-analysis. Most studies involved chronic kidney disease patients. Study designs were mostly cross-sectional with only one case–control and nine cohorts. FGF-23 was positively correlated with arterial calcification (r = 0.446 [0.254–0.611], p < 0.0001 and aOR = 1.36 [1.09–1.69], p = 0.006), CIMT (r = 0.188 [0.02–0.354], p = 0.03), and PWV (r = 0.235 [0.159–0.310], p < 0.00001). By contrast, Klotho was inversely correlated with arterial calcification (r = − 0.388 [− 0.578 to − 0.159], p = 0.001) and CIMT (r = − 0.38 [− 0.53 to − 0.207], p < 0.00001). In conclusion, FGF-23 and Klotho were associated with arterial calcification, thickness, and stiffness, clarifying their role in arterial remodeling processes.

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Factors associated with carotid intima media thickness in South African children with chronic kidney disease

Cited by 2 publications

References 0 publications

Narrative Review of Carotid disease and the kidney

Narrative Review of Carotid disease and the kidney

Role of klotho and fibroblast growth factor 23 in arterial calcification, thickness, and stiffness: a meta-analysis of observational studies

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