Factors Associated with Antiretroviral Treatments Failure among HIV-Positive Patients in Congo: A Retrospective Cohort Study

Ndziessi, Gilbert; Aloumba, Axel Julius; Essie, Darius Eryx Mbou; Niama, Ange Clauvel; Mbele, Fresnovie Geladore; Diafouka, Merlin; Abena, Ange Antoine

doi:10.4236/wja.2020.104018

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“…Available data shows that over 80% of patients start treatment late and viral load is often uncontrolled [12]. Loss of follow-up is common, and medication adherence is estimated between 55.4% and 86.9% [13]. Other results revealed compliance rates of 84% during the first 12 months as well as irregular use of ARVs.…”

Section: Introductionmentioning

confidence: 99%

Long-term survival analysis of HIV patients on antiretroviral therapy in Congo: a 14 years retrospective cohort analysis, 2003-2017

Ndziessi

Niama

Nkodia

et al. 2022

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Background The long-term survival of patients on antiretroviral treatment in Congo remains less documented. Our study aimed to analyze the long-term survival of adults living with HIV on ART (Antiretroviral Therapy). Methods We conducted a historical cohort study on 2,309 adult PLHIV (People Living with HIV) followed between January 1, 2003 and December 31, 2017 whose viral load and date of initiation of ART were known. The Kaplan Meier method was used to estimate the probability of survival and the Cox regression model to identify factors associated with death. Results The median age was 49 years; the female sex was predominant with 68.56%. The probability of survival at 14 years was 83%, (95% CI (Confidence Interval) [78-87]). On the other hand, when the lost to follow-up died, it was 66% (95% CI [62-70]) in the worst scenario. Stratified cox regression analysis showed that: being male, AHR (Adjusted Hazard Ratio) = 1.65 (95% CI [1.26-2.17]) was significantly associated with death, p-value <0.0001. Furthermore, having a viral load> 1000 copies / ml, AHR = 2.56 (95% CI [1.93-3.40]), be in the advanced WHO clinical stage, in particular: stage II, AHR = 4.07 (95% CI [2.36-7.01]); stage III, AHR = 13.49 (95% CI [8.99-20.27]) and stage IV, AHR = 34.45 (95% CI [23.74-50]) were also significantly associated with death; p-value <0.0001. Conclusion The long-term survival of PLHIV is worrying despite the offer of ARVs.

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Section: Introductionmentioning

confidence: 99%