Factors associated with antihypertensive monotherapy among US adults with treated hypertension and uncontrolled blood pressure overall and by race/ethnicity, National Health and Nutrition Examination Survey 2013-2018

Zheutlin, Alexander R.; Derington, Catherine G.; King, Jordan B.; Berchie, Ransmond O; Herrick, Jennifer S.; Cohen, Jordana B.; Shimbo, Daichi; Kronish, Ian M.; Saseen, Joseph J.; Muntner, Paul; Moran, Andrew E.; Bress, Adam P.

doi:10.1016/j.ahj.2021.10.184

Cited by 3 publications

(2 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a result of these, target blood pressure goals are not met which increases the likelihood of developing renal failure. The general population's rates of controlling hypertension have dropped recently, according to data from the third National Health and Nutrition Examination Survey (NHANES III) (Zheutlin et al, 2022). The prevalence of diabetes has continued to climb which is a third factor that contributes to the rising incidence of renal failure (Cheng et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Co-Existent Hypertension with Diabetes Mellitus Exacerbates Renal Dysfunctions

Obore

Asiwe²,

Iyawe

et al. 2022

BIOMEDNATPROCH

View full text Add to dashboard Cite

Hypertension as well as diabetes mellitus has been reported to be a major risk factor for deteriorating kidney functions. However, there is paucity of reports on renal functions in a co-existence of hypertension and diabetic condition, hence, this study evaluates renal functions in hypertensive and diabetic co-morbidity. Participants were categorised into healthy, hypertension, diabetes and hypertension with diabetes group. Blood pressure was measured as well as fasting blood glucose and blood samples were collected from each participant to assay renal function indices. The results showed that there was substantial uraemia as well as a significant reduction glomerular filtration rate in co-morbid hypertension and diabetic patients. Fasting blood glucose and mean arterial blood pressure were considerably elevated while creatinine concentration was not significantly altered in comorbid hypertension and diabetic patients. This study revealed that co-existence of hypertension and diabetes mellitus exacerbated renal dysfunction comparatively to hypertension and diabetes mellitus.

show abstract

Section: Discussionmentioning

confidence: 99%

Co-Existent Hypertension with Diabetes Mellitus Exacerbates Renal Dysfunctions

Obore

Asiwe²,

Iyawe

et al. 2022

BIOMEDNATPROCH

View full text Add to dashboard Cite

show abstract

“…Real‐world antihypertensive utilization patterns have been studied extensively, but in almost all cases, the focus of these studies has been on treatment patterns in prevalent hypertension cohorts. 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 These studies provide useful insight into overall antihypertensive use in populations. However, they rarely have distinguished between patients who are early in their treatment course from those with long‐standing hypertension and who may have extensive treatment histories and multidrug regimens that have evolved over time.…”

Section: Clinical Perspectivementioning

confidence: 99%

Initial Antihypertensive Regimens in Newly Treated Patients: Real World Evidence From the OneFlorida+ Clinical Research Network

Smith

Winterstein

Gurka

et al. 2023

JAHA

View full text Add to dashboard Cite

Background Knowledge of real‐world antihypertensive use is limited to prevalent hypertension, limiting our understanding of how treatment evolves and its contribution to persistently poor blood pressure control. We sought to characterize antihypertensive initiation among new users. Methods and Results Using Medicaid and Medicare data from the OneFlorida+ Clinical Research Consortium, we identified new users of ≥1 first‐line antihypertensives (angiotensin‐converting enzyme inhibitor, calcium channel blocker, angiotensin receptor blocker, thiazide diuretic, or β‐blocker) between 2013 and 2021 among adults with diagnosed hypertension, and no antihypertensive fill during the prior 12 months. We evaluated initial antihypertensive regimens by class and drug overall and across study years and examined variation in antihypertensive initiation across demographics (sex, race, and ethnicity) and comorbidity (chronic kidney disease, diabetes, and atherosclerotic cardiovascular disease). We identified 143 054 patients initiating 188 995 antihypertensives (75% monotherapy; 25% combination therapy), with mean age 59 years and 57% of whom were women. The most commonly initiated antihypertensive class overall was angiotensin‐converting enzyme inhibitors (39%) followed by β‐blockers (31%), calcium channel blockers (24%), thiazides (19%), and angiotensin receptor blockers (11%). With the exception of β‐blockers, a single drug accounted for ≥75% of use of each class. β‐blocker use decreased (35%–26%), and calcium channel blocker use increased (24%–28%) over the study period, while initiation of most other classes remained relatively stable. We also observed significant differences in antihypertensive selection across demographic and comorbidity strata. Conclusions These findings indicate that substantial variation exists in initial antihypertensive prescribing, and there remain significant gaps between current guideline recommendations and real‐world implementation in early hypertension care.

show abstract

Evaluation and Treatment of Essential Hypertension: An Update

Cohen

Townsend

2022

nephsap

View full text Add to dashboard Cite

Factors associated with antihypertensive monotherapy among US adults with treated hypertension and uncontrolled blood pressure overall and by race/ethnicity, National Health and Nutrition Examination Survey 2013-2018

Cited by 3 publications

References 27 publications

Co-Existent Hypertension with Diabetes Mellitus Exacerbates Renal Dysfunctions

Co-Existent Hypertension with Diabetes Mellitus Exacerbates Renal Dysfunctions

Initial Antihypertensive Regimens in Newly Treated Patients: Real World Evidence From the OneFlorida+ Clinical Research Network

Evaluation and Treatment of Essential Hypertension: An Update

Contact Info

Product

Resources

About