Factors associated with a prolonged negative conversion of viral RNA in patients with COVID-19

Bennasrallah, Cyrine; Zemni, Imen; Dhouib, Wafa; Sriha, Haythem; Mezhoud, Nourhene; Bouslama, Samar; Taboubi, Wael; Beji, Meriem Oumaima; Kacem, Meriem; Abroug, Héla; Fredj, Manel Ben; Loussaief, C.; Belguith, Asma Sriha

doi:10.1016/j.ijid.2021.02.089

Cited by 27 publications

(33 citation statements)

References 21 publications

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“…However, there was no significant relationship between preexisting diabetes or hypertension and the classification of COVID-19. Consistent with the study from Bennasrallah et al, diabetes and hypertension could not act as predisposing factors for late SARS-CoV-2 viral clearance [ 11 ]. In addition, T2DM was not significantly related to prolonged viral RNA conversion time or the proportion of RPV ( P > 0.05).…”

Section: Discussionsupporting

confidence: 88%

Influence of Fasting Plasma Glucose Level on Admission of COVID-19 Patients: A Retrospective Study

Zhao

Xing

2022

Journal of Diabetes Research

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Background. The coronavirus disease 2019 (COVID-19) is a serious global health threat and has spread dramatically worldwide. Prolonged viral shedding is associated with a more severe disease course and inflammatory reaction. Blood glucose levels were significantly associated with an increased hazard ratio (HR) for poor outcomes in COVID-19 patients. Objective. Previous studies focused primarily on the relationship between blood glucose and mortality or severe outcomes, but there were few research studies on the relationship between fasting plasma glucose (FPG) and duration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA positive status. To explore the relationship between FPG levels and prolonged duration of SARS-CoV-2 viral positivity, the clinical data of COVID-19 patients were analyzed. Method. In this retrospective study, 99 cases of COVID-19 patients in Beijing Ditan Hospital were recruited, and their clinical and laboratory findings at admission were collected and analyzed. Furthermore, the risk factors for prolonged duration of SARS-CoV-2 RNA shedding were identified, and the relationship between FPG levels and the prolonged presence of SARS-CoV-2 RNA was evaluated. Result. We found that elevated FPG levels were correlated with longer duration of SARS-CoV-2 RNA positivity, classification of COVID-19, imaging changes of chest CT, inflammation-related biomarkers, and CD8+ T cell number in COVID-19 patients. In a logistic regression model, after adjusting for gender and age, COVID-19 patients with elevated FPG were more likely to had longer duration of SARS-CoV-2 RNA positivity than those with normal FPG levels (OR 3.053 [95% CI 1.343, 6.936]). Conclusion. Higher FPG levels (≥6.1 mmol/l) at admission was an independent predictor for prolonged SARS-CoV-2 shedding, regardless of a known history of diabetes. It suggests that intensive monitoring and control of blood glucose are important for all COVID-19 patients.

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Section: Discussionsupporting

confidence: 88%

Influence of Fasting Plasma Glucose Level on Admission of COVID-19 Patients: A Retrospective Study

Zhao

Xing

2022

Journal of Diabetes Research

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“…1 ). Several other studies have also revealed the presence of fever was significantly associated with prolonged DoVC ( Zhou et al, 2021 ; Bennasrallah et al, 2021 ). These patients were hypothesized to be more severely affected by the SARS-CoV-2 infection in the lungs and thus the prolonged DoVC ( Zhou et al, 2021 ).…”

Section: Discussionmentioning

confidence: 72%

Risk factors associated with prolonged viral clearance in patients with a refractory course of COVID-19: a retrospective study

Zhuang

Huang

Wang

et al. 2021

PeerJ

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Background This study aimed to characterize a cohort of patients with a refractory course of COVID-19, and to investigate factors associated with the duration of viral clearance (DoVC). Materials & Methods A total of 65 patients with refractory COVID-19 were retrospectively enrolled from Huoshenshan Hospital. Univariate analysis and multivariate analysis were performed to examine the potential association between clinicopathologic characteristics and the DoVC. Results The median DoVC in the overall study cohort was 48 days (ranged from 21 to 104 days). Multivariate analysis indicated that fever at illness onset (Hazard ratio (HR) = 4.897, 95% CI [1.809–13.260], p = 0.002), serum level of aspartate aminotransferase (AST) > 21.8 IU/L (HR = 3.010, 95% CI [1.195–7.578], p = 0.019), and titer of SARS-CoV-2 IgG > 142.09 AU/ml (HR = 3.061, 95% CI [1.263–7.415], p = 0.013) were the three independent risk factors associated with delayed viral clearance. Conclusion The current study suggested that clinical characteristics such as fever at illness onset, a high serum level of AST or SARS-CoV-2 IgG were associated with delayed viral clearance. Patients with these characteristics might need a more individualized treatment strategy to accelerate their recovery from the refractory COVID-19.

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“…18 Vulnerabilities to contagions are especially related to the level and duration of exposure. 19 The longer a person is exposed to a source of infection, the higher the likelihood of being infected. Traditional gender roles attributed to different gender strata in Africa demand men to work outdoors and secure resources for the family while women stay at home.…”

Section: Discussion and Implications For Translationmentioning

confidence: 99%

Profiles and Characteristics of Patients with Mild to Moderate COVID -19 Disease Phenotypes in a Teaching Hospital in Kano, Northern Nigeria

Musa

Waziri

Amina

et al. 2022

Int. J. Transl Med Res Public Health

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Background and Introduction: COVID-19 has affected almost 180 million people around the world, causing the death of about 5 million persons, as of November 16, 2021. The disease presents with a plethora of pulmonary and extrapulmonary symptoms of varying severity. After an exhaustive review of the literature, we found no data on the mild and moderate COVID-19 disease phenotypes in Northern Nigeria. Our objective is to describe the clinical characteristics of non-severe COVID -19 disease phenotypes in Kano State. Methods: This is a retrospective cohort study at the COVID-19 Isolation Center of Muhammad Buhari Specialist Hospital Kano, Nigeria. We included all patients admitted from May 2020 to December 2020. Patients’ medical records were assessed and evaluated to describe the clinical characteristics at presentation. We explored time to discharge between patients aged ≤ 50 years old versus those >50. We applied the Kaplan-Meier product-limit estimator to generate cumulative probabilities of discharge over time and used the Log-rank test to determine differences between the two age groups. We applied Cox Proportional Hazards to identify predictors of time to discharge among the patients in the study. The study variables comprised of time of viral clearance and time to discharge as outcome variables, while main exposure variables included, age, sex, occupation, mode of exposure, presence of co-morbidity, and duration of hospitalization. Results: A total of 187 COVID-19 patients were reviewed. The commonest symptoms were fever, breathing difficulty, and dry cough. There was no recorded death. Contact with a confirmed COVID-19 positive person was the source of infection in 167(89.3%) of patients. We noted faster time to viral clearance in patients on lopinavir compared to those on chloroquine (Log-rank test p-value = 0.048). There were no significant differences in time to discharge between younger (< 50 years) versus older patients (≥ 50 years) [24 days vs. 26 days respectively; Log-rank test p-value = 0.082]. Age, sex, and source of infection did not appear to be predictors of infection phenotype. Conclusion and Implications for Translation: The findings of this study have a bearing on the surveillance and diagnosis of COVID-19 in Nigeria. While the plethora of clinical features may not be limited to infection with the SARS-CoV-2 virus, healthcare practitioners should consider these symptom clusters in addition to cognate contact and travel history when confronted with a suspected COVID-19 infection. Copyright © 2022 Maiyaki et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY 4.0.

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Factors associated with a prolonged negative conversion of viral RNA in patients with COVID-19

Cited by 27 publications

References 21 publications

Influence of Fasting Plasma Glucose Level on Admission of COVID-19 Patients: A Retrospective Study

Influence of Fasting Plasma Glucose Level on Admission of COVID-19 Patients: A Retrospective Study

Risk factors associated with prolonged viral clearance in patients with a refractory course of COVID-19: a retrospective study

Profiles and Characteristics of Patients with Mild to Moderate COVID -19 Disease Phenotypes in a Teaching Hospital in Kano, Northern Nigeria

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