Factors associated with 25-hydroxyvitamin D level in Chinese hospitalized patients with systemic lupus erythematosus: a retrospective cohort study

Zhang, Xueyi; Guo, Qingqing; Sun, Siqin; Tang, Xiaojun; Shen, Wei; Liang, Jun; Yao, Genhong; Geng, Linyu; Ding, Shuai; Chen, Hongwei; Wang, Hong; Hua, Bingzhu; Wang, Dandan; Zhang, Huayong; Feng, Xuebing; Sun, Lingyun; Jin, Ziyi

doi:10.1007/s00296-023-05465-5

Cited by 1 publication

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“…Several autoimmune diseases tend to share a predisposition to vitamin D deficiency, which might produce an alteration of the microbiome and disrupt the integrity of the intestinal epithelial barrier [18]. It has been also suggested that vitamin D deficiency may play a role in the immune activation of patients with systemic lupus erythematosus, and have an active part in many comorbidities and even complications of this disorder [19]. Long-term treatment with vitamin D provided an enhancement of T-reg cells and production of Th2 cytokines in patients with systemic lupus erythematosus [20].…”

Section: Discussionmentioning

confidence: 99%

Predictors of Gastrointestinal Involvement in Children with IgA Vasculitis: Results from a Single-Center Cohort Observational Study

Rigante,

Guerriero,

Silvaroli

et al. 2024

Children

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Background and objective: IgA vasculitis (IgAV), a predominantly pediatric leukocytoclastic disease, has an unpredictable, though largely benign, evolution. The aim of this study was to retrospectively investigate any potential clinical or laboratory predictors of gastrointestinal involvement in a single-center cohort of children with IgAV. Patients and methods: A total of 195 children with a history of IgAV, regularly followed-up for an average period of 1 ± 2.6 years via outpatients clinics of the pediatric rheumatology unit in our University, were assessed, analyzing their clinical and laboratory variables in relationship with their disease evolution and outcome. Results: Univariate analysis showed that a higher neutrophil granulocyte count and lower lymphocyte count (expressed as a percentage of the total white blood cells) were significantly associated with the presence of gastrointestinal involvement at the first examination (65.2 ± 13% versus 58.8 ± 12%, p = 0.02, and 26.4 ± 11% versus 32.1 ± 11%, p = 0.02, respectively). A positive pharyngeal swab for Streptococcus pyogenes, a deficiency of 25-hydroxyvitamin D, a persistence of purpuric rash for more than 1 month, and purpuric lesions in the genital area were also associated with gastrointestinal involvement (p = 0.0001, p = 0.0001, p = 0.007 and p = 0.001, respectively). However, multiple logistic regressions with correction for the patients’ sex and age showed that lower 25-hydroxyvitamin D levels, persistent rash, and genital lesions were independently and significantly associated with signs of gastrointestinal involvement. We then performed a secondary analysis (both univariate and multivariate) to investigate whether vitamin D deficiency was associated with other IgAV manifestations: we found that only 25-hydroxyvitamin D deficiency remained significantly associated with gastrointestinal involvement in IgAV. Conclusions: Patients with IgAV and vitamin D deficiency might be more prone to developing gastrointestinal manifestations of variable severity.

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Section: Discussionmentioning

confidence: 99%