Factors Altering the Responsiveness of Mice to Hexobarbital

Es, Vesell

doi:10.1159/000135949

Cited by 93 publications

(30 citation statements)

References 9 publications

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“…These results confirmed the genetic influences on· barbiturate sleeping time reported by Jay (1955), McLaren and Michie (1956) and Vesell (1968). Differences in the strain rankings between the various studies may exist because of different barbiturates, substrains and environmental conditions used by the investigators.…”

Section: Discussionsupporting

confidence: 85%

“…(1964) and Vesell (1968) who found a sex difference. The finding of a genotype x sex interaction indicates that the presence or absence of a sex difference may be dependent on the strain used in a study.…”

Section: Discussionmentioning

confidence: 96%

“…Vesell (1968), Jori, Bianchetti and Prestini (1970), Gillete (1976) and others have demonstrated that variation in hexobarbitone sleeping time is due to variation in metabolic disappearance and not to differences in receptor sensitivity in the brain.…”

mentioning

confidence: 99%

“…Genetic differences in response to drugs have been described, including the length of narcosis induced by barbiturates (Jay, 1955;McLaren & Michie, 1956;Brown, 1961;Vesell, 1968). Variation within inbred strains, their F, hybrids and outbred colonies was studied to find the best animals for biological assay.…”

mentioning

confidence: 99%

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Variation in pentobarbitone sleeping time in mice 1. Strain and sex differences

Lovell

1986

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85Summary A set of 23 inbred strains of mice was tested for their sleeping time under sodium pentobarbitone anaesthetic. Highly significant strain differences were found. Estimates of the proportion of the variation accounted for by genetic differences ranged from 28% to 42%. In general, males slept longer than females but the size of the sex differences was not consistent across strains. Sleeping times on different test days also varied, indicating that environmental factors were affecting the results. A specially designed experiment failed to detect any differences in within-strain variation.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 96%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Variation in pentobarbitone sleeping time in mice 1. Strain and sex differences

Lovell

1986

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“…It appears that sexual differences in drug metabolism are strain-dependent in the mouse (Vesell, 1968). Depending upon the strain, hepatic mono-oxygenase activities may be greater in the male, or in the female, or no sex differences may exist.…”

Section: Introductionmentioning

confidence: 99%