Factors affecting transmission of mucosal human papillomavirus

Veldhuijzen, Nienke J.; Snijders, Peter J.F.; Reiss, Peter; Meijer, Chris J.L.M.; Wijgert, Janneke van de

doi:10.1016/s1473-3099(10)70190-0

Cited by 149 publications

(156 citation statements)

References 138 publications

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“…These potentially provide an enabling environment for HSV-2 or HIV entry and replication. Just like HSV-2, HPV is believed to be more infectious than HIV, with prevalence always exceeding that of HIV and the most infectious of the three viruses [36]. Therefore, if the interaction between HSV-2 and HPV found in this study is confirmed by other studies, HPV vaccination would be a recommended strategy for HSV-2 prevention in addition to safer sexual practices.…”

Section: Discussionsupporting

confidence: 58%

Prevalence, Incidence and Risk Factors for Acquisition of Herpes Simplex Virus Type 2 among Fishermen on the Shores of Lake Victoria in Kisumu County, Kenya

Ondondo¹,

Ng’ang’a²,

Mpoke³

et al. 2014

AID

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Background: Herpes simplex virus Type 2 (HSV-2) has been associated with HIV infection. More recently, HSV-2 incidence has been linked to HIV acquisition. A few studies have suggested that the fishing communities have a high HSV-2 prevalence but there is limited knowledge on HSV-2 incidence and associated risk factors among fishermen. Methods: Three hundred fishermen were consented, and evaluated for baseline HSV-2 serology status and again after 12 months among those negative at baseline. Sexual behavior and socio-demographic data were collected at enrolment and exit visits using a structured questionnaire. Baseline HIV serology and Human papillomavirus (HPV) DNA genotyping were also performed. Multivariate logistic regression was used to determine independent factors associated with HSV-2 acquisition. Results: Baseline HSV-2 prevalence was 56.3% (95% CI: 50.7 -62.0). Factors associated with HSV-2 prevalence were, older age

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Section: Discussionsupporting

confidence: 58%

Prevalence, Incidence and Risk Factors for Acquisition of Herpes Simplex Virus Type 2 among Fishermen on the Shores of Lake Victoria in Kisumu County, Kenya

Ondondo¹,

Ng’ang’a²,

Mpoke³

et al. 2014

AID

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“…Very few women were found to be taking alcoholic beverages. Tobacco and alcohol increase the risk of persistent High risk HPV infection and unsafe sexual practices (Veldhuijzen et al, 2010). Male circumcision rate in our study was 6.4% and according to meta-analysis study circumcision reduces HPV infection and high risk HPV prevalence among men (Albero et al, 2012).…”

Section: Discussionmentioning

confidence: 45%

“…But the mean age at first sexual contact was 15 years and high number of teenage pregnancies were reported among these women (Sauvaget et al, 2011). Immature transformation zone is mainly susceptible to HPV infection and younger age at sexual debut is a well-recognized risk factor for HPV infection (Veldhuijzen et al, 2010). In Perdoor study only one woman had multiple sexual partners and two women reported extramarital relations of their husbands.…”

Section: Discussionmentioning

confidence: 89%

Detection of Genital HPV Infection Using Urine Samples: a Population Based Study in India

Sabeena

Bhat²,

Kamath

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Background: Cervical cancer is the second commonest cancer among Indian women and its association with human papilloma virus (HPV) is well established. This preventable cancer accounts for the maximum number of cancer related deaths among rural Indian women. Unlike in developed countries there are no organized cervical cancer screening programmes in India due to lack of resources and manpower. Objective: To detect genital HPV infection using urine samples among asymptomatic rural women in the age group of 18-65 years. Materials and Methods: The study area chosen was Perdoor village in Udupi Taluk, Karnataka State and all the women in the age group of 18-65 years formed the study cohort. A cross sectional study was conducted by house visits and 1,305 women were enrolled in the study. After taking written informed consent a data sheet was filled and early stream random urine samples were collected, transported to a laboratory at 4 O C and aliquoted. Samples were tested using nested HPV PCR with PGMY09/11 and GP5+/6+ primers. Positive cases were genotyped by sequence analysis. Results: Study participants included 1,134 sexually active and 171 unmarried women with a mean age at marriage of 22.1 (SD=3.9) years. Study area showed high female literacy rate of 86.6%. Five urine samples tested positive for HPV DNA (0.4%). Conclusions: We found very low genital HPV infection rate among women from monogamous community. This is the first major population based study carried out among asymptomatic rural women to detect genital HPV infectio from Karnataka using urine samples.

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“…The probability of transmission is very high, with an estimated life-time risk of cervical HPV infection in sexually active women of up to 80%. Exposure to HPV is determined by well known risk factors for most sexually transmitted infections, while determinants of susceptibility and infectivity are much less established [12]. Knowledge on the natural history of HPV infection derives from studies on cervical infection.…”

Section: Human Papillomaviruses (Hpvs)mentioning

confidence: 99%

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2014

Oncotarget

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Human papillomaviruses (HPVs)Human papillomaviruses (HPVs) are small doublestranded DNA viruses that comprise a heterogeneous family consisting of more than 130 different HPV types [1]. Different HPV types have been detected in the anogenital tract, urethra, skin, larynx, tracheobronchial and oral mucosa and can cause a wide range of infections, including common warts, genital warts, recurrent respiratory papillomatosis, low-grade and high-grade squamous intraepithelial lesions (SILs), anal cancer, vaginal cancer and cervical cancer. Based on their association with cervical cancer, HPV types are classified as high-risk 18, 31, 33, 35,39,45,51,52,56,58,59,68, 30, 34,53,66,67,69,70,73,82,85) [2]. Evidence of the potential role of HPV in other tumor types has been shown, as well [3][4][5][6][7][8]. High-risk HPV types contribute significantly to viral associated neoplasms, accounting for approximately 600,000 cases (5%) of cancers worldwide annually [9]. In particular, HPV-16 accounts for approximately 50% of cervical carcinomas and more than 90% of HPV(+) carcinomas of the oropharynx (and the other ano-genital sites). Low-risk HPVs have been associated with benign warts of oral and urogenital epithelium in adults as well as children and they are only rarely found in malignant

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Factors affecting transmission of mucosal human papillomavirus

Cited by 149 publications

References 138 publications

Prevalence, Incidence and Risk Factors for Acquisition of Herpes Simplex Virus Type 2 among Fishermen on the Shores of Lake Victoria in Kisumu County, Kenya

Prevalence, Incidence and Risk Factors for Acquisition of Herpes Simplex Virus Type 2 among Fishermen on the Shores of Lake Victoria in Kisumu County, Kenya

Detection of Genital HPV Infection Using Urine Samples: a Population Based Study in India

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