Factors affecting the yield of endoscopic transpapillary bile duct biopsy for the diagnosis of pancreatic head cancer

IgG4‐related sclerosing cholangitis without obvious pancreatic lesion: Difficulty in differential diagnosis

“…In our case series, except for one patient (case 2), no false positive result has been recorded in the histological diagnosis of biliary biopsy tissues, in contrast to a high sensitivity (>90%) for biliary cancer detection. 20 This sensitivity is similar to that of EUS-FNA in the diagnosis of pancreatic cancer 21 which has been routinely applied for the exclusion of pancreatic cancer. 2,22 Hence, if malignant tissues can obtained from the biliary stenotic site, the imaging findings should be rechecked, the serum markers be re-tested and the biopsy be repeated.…”

Predictive factors for positive diagnosis of malignant biliary strictures by transpapillary brush cytology and forceps biopsy

“…In the present study, bile duct cancer, stricture length ≥30 mm and TB ≥4 mg/dL were significant factors for a positive diagnosis of malignancy by forceps biopsy in the multivariate analysis. Kimura et al 11 reported that serum bilirubin level ≥10 mg/dL and at least three tissue samples obtained were independent predictive factors for a positive diagnosis of pancreatic cancer by forceps biopsy. In several studies, a high serum bilirubin level has been reported as an independent predictor for a positive diagnosis of malignancy.…”

“…Therefore, it is important to clarify the predictive factors associated with a positive diagnosis by brush cytology and forceps biopsy in the assessment of alternative sampling procedures after a negative result by brush cytology and forceps biopsy. Several studies have reported predictive factors for brush cytology and forceps biopsy in MBS, such as elder age, high serum bilirubin levels, non‐flat lesions and mass on the imaging examination, etc . However, these studies also included relatively few patients.…”

“…Several studies have reported predictive factors for brush cytology and forceps biopsy in MBS, such as elder age, high serum bilirubin levels, non-flat lesions and mass on the imaging examination, etc. [10][11][12] However, these studies also included relatively few patients.…”

Diagnosis Autoimmune Pancreatitis

“…In this sense, periampullary forceps biopsy (and cytology) should be added in cases with biliary stricture, as this method has high sensitivity for confirming cancer tissue in the biliary cancer cases (77% [69,70] -92% [71] ).…”