Factors Affecting the Variability of Ovulation Rates after PMSG Stimulation

Saumande, J.; Chupín, D.; Mariana, J. C.; Ortavant, R.; Mauléon, P.

doi:10.1007/978-94-009-9753-0_11

Cited by 28 publications

(16 citation statements)

References 19 publications

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“…In contrast to healthy follicles 0-8-2-0 mm in diameter which form the reserve from which PMSG recruits follicles for ovulation, the number of follicles >2mm in diameter was negatively correlated with PMSG-induced ovulation rate (r = -0-29 and -0-61 in Exps 1 and 2 respectively). This has previously been reported for cattle: when response to PMSG was related to the features of the surface follicular population, ovaries devoid of large follicles and rich in small ones had the highest response (Saumande et al, 1978). Administration of PMSG, together with a luteolytic agent at different days of the luteal phase, produces a higher response after Day 8 (Phillippo & Rowson, 1975;Sreenan et al, 1978) (Schams et al, 1978).…”

Section: Discussionsupporting

confidence: 55%

Ovarian features contributing to the variability of PMSG-induced ovulation rate in sheep

Driancourt¹

1987

Reproduction

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Section: Discussionsupporting

confidence: 55%

Ovarian features contributing to the variability of PMSG-induced ovulation rate in sheep

Driancourt¹

1987

Reproduction

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“…In our study, when heifers with a poor response were excluded from calculations, the differences in ovulation rate between groups given PMSG (2000 IU) or BST + PMSG (2000 IU) failed to reach statistical significance. It has been reported that while the superovulatory response increases with increasing dose of PMSG, the variability between animals also increases [40]. BST may therefore be useful in reducing between-animal variability in superovulatory response; however, this needs to be confirmed by a study using larger groups of animals.…”

Section: Discussionmentioning

confidence: 92%

“…The number of heifers with a poor response (defined as an ovulation rate of < 3 and/or the development of either follicular cysts or cystic ovaries; see also [40]) was significantly reduced by BST pretreatment. Similarly, in the study of Reiger et al [13], 21% of the heifers of the control group had a response of -5 ovulations compared to none in the group co-treated with BST.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Recombinant Bovine Somatotropin on the Superovulatory Response to Pregnant Mare Serum Gonadotropin in Heifers

Gong

Bramley

Wilmut

et al. 1993

Biology of Reproduction

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Treatment of mature heifers with recombinant bovine somatotropin (BST) increases the number of ovarian follicles of 2-5 mm in diameter. This study was carried out to investigate whether the increase in the number of small follicles induced by BST treatment can enhance the superovulatory response. In the first experiment, 24 heifers were assigned, in a randomized block design, to four treatment groups: 1) control; 2) BST; 3) pregnant mare serum gonadotropin (PMSG); 4) BST+PMSG. On Day 7 of the estrous cycle, animals in groups 2 and 4 received injections of 320 mg BST (in a sustained release formulation), while heifers in groups 1 and 3 received 10 ml saline. Five days later heifers in groups 3 and 4 were treated with a single dose of 2000 IU PMSG to induce superovulation. Embryos were recovered nonsurgically on Days 6-8 of the following cycle, and all heifers underwent laparoscopy on Day 9 to assess ovulation rate. In a second experiment, 24 heifers were assigned randomly to four treatment groups: 1) PMSG (1000 IU); 2) BST (320 mg) + PMSG (1000 IU); 3) PMSG (2000 IU); 4) BST (320 mg) + PMSG (2000 IU), and then treated as for experiment I. In both experiments, all heifers were scanned daily using real-time ultrasound from the day before BST injection until the day of ovulation to monitor dynamics of ovarian follicular growth and development, and blood samples were collected daily throughout the experimental period for measurement of peripheral progesterone, estradiol-17 beta, growth hormone (GH), and insulin-like growth factor-I (IGF-I).(ABSTRACT TRUNCATED AT 250 WORDS)

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“…It has been shown to have a half-life of 40 h in the cow and persists for up to 10 days in bovine circulation; thus it is normally injected once followed by a PGF injection, 48 h later [18]. The long halflife of eCG causes continued ovarian stimulation, unovulated follicles, abnormal endocrine profiles and reduced embryo quality [32,34,41]. These problems have been largely overcome by the intravenous injection of antibodies to eCG at the time of the first insemination, 12 to 18 h after the onset of estrus [18,21].…”

Section: Gonadotrophins and Superovulationmentioning

confidence: 99%

Recent advances in the superovulation in cattle

Steward²,

2002

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mercial embryo transfer records. In a report of 2048 beef donor collections, a mean of 11.5 ova/embryos with 6.2 transferable embryos were collected from each cow [27]. However, the variability was great in both the superovulatory response and embryo quality; 24% of the collections did not produce viable embryos, 64% produced fewer INTRODUCTIONThe objective of superstimulatory treatments in the cow is to obtain a maximum number of fertilized and transferable embryos with a high probability of producing pregnancies [6]. Wide ranges in superovulatory response and embryo yield have been detailed in several reviews of com- Abstract -The variability in the superovulatory response continues to be one of the most frustrating problems with embryo transfer in cattle. The removal of LH from pituitary extracts has tended to reduce the variability in response, and several studies involving the use of the purified porcine pituitary extract, Folltropin ® -V are reviewed. The major source of variability in the superovulatory response in cattle is the status of ovarian follicles at the time of initiation of gonadotrophin treatments. Data support the benefits of initiating gonadotrophin treatments at the time of emergence of a follicular wave. Incorporation of techniques designed to control follicular wave dynamics, such as follicular ablation, or treatment with estradiol/progesterone, have reduced the variability caused by treating cows at different stages of follicular development, and at the same time improved response by taking advantage of endogenous recruitment and selection mechanisms. New protocols offer the convenience of being able to initiate gonadotrophin treatments quickly and at a self-appointed time, without the necessity of estrus detection and without sacrificing response. Methods can be used for repeated superstimulation of donor animals at 25 to 30 day intervals, without regard to estrus detection or stage of the estrous cycle, and without compromising embryo production. superstimulation / gonadotrophin / FSH / LH / follicular waves / embryo transfer / cattle Reprod. Nutr. Dev. 42 (2002) [601][602][603][604][605][606][607][608][609][610][611] 601 Communication

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Factors Affecting the Variability of Ovulation Rates after PMSG Stimulation

Cited by 28 publications

References 19 publications

Ovarian features contributing to the variability of PMSG-induced ovulation rate in sheep

Ovarian features contributing to the variability of PMSG-induced ovulation rate in sheep

Effect of Recombinant Bovine Somatotropin on the Superovulatory Response to Pregnant Mare Serum Gonadotropin in Heifers

Recent advances in the superovulation in cattle

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