Abstract:Mechanical factors that can modify the peak transvalvar pressure difference (ΔP) in aortic stenosis were evaluated in a model. A latex rubber sac simulated the ventricle. Expansion of the walls of the sac by means of a negative pressure applied to its outer wall introduced a measured volume into the sac and placed the wall materials under tension. The stretched sac was then permitted to contract and to expel its contents through ‘aortic valvar’ orifices of various severities of stenosis, into an aortic standpi… Show more
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