Factors Affecting the Phase Behavior and Antimicrobial Activity of Carvacrol Microemulsions

Shaaban, Hamdy A.; Edris, Amr E.

doi:10.5650/jos.ess14194

Cited by 27 publications

(11 citation statements)

References 53 publications

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“…Specifically, the antimicrobial efficacy of EOs in microemulsions can be affected by the structure and quantity of surfactants, the composition of oil phase, and the composition of media. Shaaban and Edris (2015) showed that carvacrol microemulsion formulated with cationic cetylpyridinium chloride had a significantly higher antimicrobial activity than that formulated with Tween 20. Glycerol monolaurate microemulsions prepared with ethoxylated sorbitan esters and sucrose esters were observed to have an improved antimicrobial activity than free glycerol monolaurate (Zhang et al, 2007).…”

Section: Effect Of Tween 80 Content On the Antimicrobial Activity Of Eosmentioning

confidence: 98%

Antimicrobial properties of microemulsions formulated with essential oils, soybean oil, and Tween 80

Davidson

Zhong

2016

International Journal of Food Microbiology

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It was previously found that blending soybean oil with cinnamon bark oil (CBO), eugenol or thyme oil, Tween 80, and equal masses of water and propylene glycol could be used to prepare microemulsions. In the present study, the objective was to determine the antimicrobial activity of the microemulsions in tryptic soy broth (TSB) and 2% reduced fat milk. In TSB, the minimum inhibitory concentration (MIC) of CBO solubilized in microemulsions was up to 625 ppm against cocktails of Listeria monocytogenes, Salmonella enterica or Escherichia coli O157:H7, which was equal to or higher in concentration than free CBO dissolved in ethanol. However, MICs of eugenol or thyme oil in microemulsions were much higher than that of free antimicrobials. Therefore, microemulsions of CBO were chosen to do further study. Inactivation curves of L. monocytogenes or E. coli O157:H7 in TSB or 2% reduced fat milk were tested and fitted using the Weibull model. In TSB, a gradual decrease in cell viability of L. monocytogenes and E. coli O157:H7 was observed with the microemulsion treatments at 625 ppm CBO, which was in contrast to the more rapid and greater inactivation by free CBO. Gradual inactivation of L. monocytogenes in 2% reduced fat milk was also observed in the treatment with 10,000 ppm free or microemulsified CBO. When fitted using the Weibull model, the predicted time to obtain a 3-log decrease of L. monocytogenes and E. coli O157:H7 in TSB or 2% reduced fat milk increased with an increased amount of soybean oil in microemulsions. Additionally, increasing the amount of Tween 80 in mixtures with different mass ratios of Tween 80 and essential oils significantly decreased the log reductions of L. monocytogenes in TSB. Our study showed that microemulsions can be used to dissolve EOs and control the rate of inactivating bacteria, but the composition of microemulsions is to be carefully chosen to minimize the reduction of antimicrobial activities.

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Section: Effect Of Tween 80 Content On the Antimicrobial Activity Of Eosmentioning

confidence: 98%

Antimicrobial properties of microemulsions formulated with essential oils, soybean oil, and Tween 80

Davidson

Zhong

2016

International Journal of Food Microbiology

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“…Tween 80 surfactant is a polyethylene sorbitan ester (polysorbate), non-ionic widely used commercially to solubilize oil into water (Narayanan 2008 ). Its action can be limited due to their high viscosity (Shaaban & Edris 2015 ) and probably is not suitable for use in formulating a topical solution containing BISA.…”

Section: Discussionmentioning

confidence: 99%

“…2014 ). It can form a film between BISA and water, increasing the elasticity and surface tension of the solution and can lead to the formation of a soluble solution, possibly allowing the antinociceptive effect of BISA (Shaaban & Edris 2015 ), since BISA, when in solution with propylene glycol, showed highly significant analgesic effect, reducing the nociceptive behaviour at 93.5%.…”

Section: Discussionmentioning

confidence: 99%

Corneal antinociceptive effect of (-)-α-bisabolol

Teixeira

Costa

Campos

2017

Pharmaceutical Biology

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Context: (-)-α-Bisabolol (BISA) is a sesquiterpene alcohol widely used as scent in cosmetic preparations, perfumes, shampoos, toilet soaps and other toiletries with potential for use in the pharmaceutical area.Objective: To evaluate the corneal antinociceptive efficacy of BISA and to analyze the best solubilizing agent.Materials and methods: Acute corneal nociception was induced by the local application of hypertonic saline (5 M NaCl; 20 μL) to the corneal surface of Swiss mice (n = 8/group) 60 min after topical treatment with solutions or ointment containing BISA (50–200 mg/mL). The number of eye wipes performed with the ipsilateral forepaw was counted for a period of 30 s. Control groups (vehicles) were included.Results: BISA (50, 100 or 200 mg/mL) solubilized with Tween 80 did not reduce the number of eye wipes. Animals treated with the ointment (BISA 50, 100 or 200 mg/mL; p < 0.001), as well the solution containing propylene glycol (BISA 100 mg/mL; p < 0.05), showed significant reduction in the number of nociceptive behaviours. Solutions containing propylene glycol and isopropyl myristate had no effects.Discussion and conclusion: BISA possess corneal antinociceptive activity. Although the ointment presented antinociceptive effect, it is concluded that BISA when associated with propylene glycol has better potential for corneal nociceptive pain since it is more comfortable to use, leading to greater acceptance by patients.

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“…), 1‐monoacylglycerol of lauric acid (Petra et al . ), carvacrol (Shaaban and Edris ), ethyl oleate (Al‐Adham et al . , ), eucalyptus oil (Sugumar et al .…”

Section: Antimicrobial Activity Of Essential Oil Micro‐ and Nanoemulsmentioning

confidence: 99%

“…), monolaurin (Fu et al . ), carvacrol (Shaaban and Edris ), sage oil (Moghimi et al . ) and thyme oil (Moghimi et al .…”

Section: Antimicrobial Activity Of Essential Oil Micro‐ and Nanoemulsmentioning

confidence: 99%

Essential oil micro- and nanoemulsions: promising roles in antimicrobial therapy targeting human pathogens

Franklyne

Mukherjee

Chandrasekaran

2016

Lett Appl Microbiol

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Antimicrobial resistance is a major health concern worldwide. A narrowing of the antibiotic development pipeline and a resurgence in public opinion towards 'natural' therapies have renewed the interest in using essential oils as antimicrobial agents. The drawbacks of bulk dosing of essential oils can be mitigated by formulating them as micro- and nanoemulsions. These emulsions have an added advantage as they are in the nanometre size range whose thermodynamic properties enable them to be used as an effective drug delivery system. This review describes the current work on the antimicrobial activities of essential oil micro- and nanoemulsions and their role as drug delivery vehicles.

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Factors Affecting the Phase Behavior and Antimicrobial Activity of Carvacrol Microemulsions

Cited by 27 publications

References 53 publications

Antimicrobial properties of microemulsions formulated with essential oils, soybean oil, and Tween 80

Antimicrobial properties of microemulsions formulated with essential oils, soybean oil, and Tween 80

Corneal antinociceptive effect of (-)-α-bisabolol

Essential oil micro- and nanoemulsions: promising roles in antimicrobial therapy targeting human pathogens

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