Factors affecting the occurrence of symptomatic intracerebral haemorrhage after intravenous thrombolysis depending on the haemorrhage definition

Śledzińska-Dźwigał, Monika; Sobolewski, Piotr; Szczuchniak, Wiktor

doi:10.5114/ninp.2013.38220

Cited by 2 publications

(2 citation statements)

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“…Thrombolytic treatment has been shown to increase the risk of haemorrhage and cause earlier HT 30 . Increased arterial stiffness has been found to be an independent predictor of HT in patients receiving thrombolysis 31 .…”

Section: Discussionmentioning

confidence: 99%

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Haemorrhagic transformation following ischaemic stroke: A retrospective study

Pande

Win

Khine

et al. 2020

Sci Rep

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The aim of this study was to identify the prevalence of haemorrhagic transformation (HT) in patients with ischaemic stroke, and evaluate its association with medical comorbidities, stroke subtypes, premorbid medication, and long-term survival. To achieve this, we performed a retrospective analysis of 527 consecutive stroke rehabilitation patients. Of these, 102 (19.4%) developed HT. Older patients, and those with large artery strokes, had a higher risk of HT. Forty-one patients received alteplase (rtPA), of which 15 (36.6%) developed HT. A total of 129 (24.5%) patients were taking aspirin prior to their stroke and, of these, 39 (30.2%) developed HT. Twenty-three (4.36%) patients were taking vitamin k antagonists, prior to stroke, of which 14 (60.9%) developed HT. There were 102 patients (19.35%) with underlying atrial fibrillation, of whom 55 (53.9%) developed HT. Patients with known ischaemic heart disease had an increased risk of HT, and patients with HT had significantly lower total cholesterol levels (4.96 vs. 5.34) and lower LDL cholesterol levels (3.20 vs. 3.5). In conclusion, older age, atrial fibrillation, treatment with oral anticoagulants and antiplatelet medications prior to stroke, low total and LDL cholesterol, and rtPA use, are all associated with HT. Survival was not affected by the presence of HT.

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Section: Discussionmentioning

confidence: 99%

“…Data from studies of HT or SICH suggest an incidence of 6.4-30%, and up to 43% of combined HT and SICH cases 9,11,15,17,30 . In our study, thrombolysis with rtPA was performed in 39 (8%) patients, of which 16 (41%) developed HT.…”

Section: Discussionmentioning

confidence: 99%