Factors Affecting the Lifetime of Third-Generation Voice Prosthesis After Total Laryngectomy

Pribuišis, Kipras; Pašvenskaitė, Agnė; Liutkevičius, Vykintas; Pajėdienė, Gabija; Gaučė, Gabija; Uloza, Virgilijus

doi:10.1016/j.jvoice.2022.01.027

Cited by 3 publications

(3 citation statements)

References 29 publications

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“…Biofilms are complex microbial communities encased in a self-generated extracellular matrix that promotes the adhesion and protection of microorganisms. Anaerobic and microaerophilic pathogens, particularly adept at surviving in low-oxygen environments, contribute significantly to the initiation and persistence of biofilms on VPs [ 13 ]. The objective of this prospective study is to explore the associations between the microflora’s presence and the malfunction of VPs, along with the association between the predominant microorganism and the longevity of VPs.…”

Section: Introductionmentioning

confidence: 99%

Is Oral Microflora Related to Development of Malfunction in Patients Using Voice Prosthesis?

Immordino,

Dispenza,

Sireci

et al. 2024

JCM

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Background: this prospective study investigated the correlation between the oral bacterial microflora and the microflora found in voice prostheses (VPs) among 20 patients who had undergone laryngectomy. The aim was to explore the associations between the microflora’s presence and the malfunction of VPs, along with the association between the predominant microorganism and the longevity of VPs. Methods: the research process included gathering medical histories, conducting ENT examinations, replacing VPs, and performing check-ups every four months for a period of 15.5 months. Additionally, microbiological examinations, blood tests, and voice change surveys were conducted. Results: a correlation between the microflora isolated from VPs and that from oral rinses was demonstrated in a large percentage of patients who experienced a loss of prosthetic functional efficiency. The correlation analysis between the type of microorganism and the lifespan of VPs showed a non-significant Pearson correlation coefficient (r = 0.043, p = 0.678). Conclusions: there is no significant linear correlation between the predominant microorganism and the average lifespan of VPs.

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Section: Introductionmentioning

confidence: 99%

Is Oral Microflora Related to Development of Malfunction in Patients Using Voice Prosthesis?

Immordino,

Dispenza,

Sireci

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

“…15 • Voice prostheses often fail within the first few months due to the growth of Candida albicans (C. albicans). 16,17 While the virulence potential remains controversial, 18,19 C. albicans growth causes early valve failure, compromised speech, and aspiration pneumonia. 20 For these devices and others, 21,22 the emerging threat of drug resistance among pathogens has resulted in higher hospital costs, longer hospital stays, increased hospital mortality, and even morbidity.…”

Section: ■ Introductionmentioning

confidence: 99%

“… Voice prostheses often fail within the first few months due to the growth of Candida albicans (C. albicans). , While the virulence potential remains controversial, , C. albicans growth causes early valve failure, compromised speech, and aspiration pneumonia …”

Section: Introductionmentioning

confidence: 99%

Facile Modification of Medical-Grade Silicone for Antimicrobial Effectiveness and Biocompatibility: A Potential Therapeutic Strategy against Bacterial Biofilms

Wynne,

Zolotarskaya,

Jarrell

et al. 2023

ACS Appl. Mater. Interfaces

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A one-step modification of biomedical silicone tubing with N,N-dimethyltetradecylamine, C14, results in a composition designated WinGard-1 (WG-1, 1.1 wt % C14). A surface-active silicon-amine phase (SAP) is proposed to account for increased wettability and increased surface charge. To understand the mechanism of antimicrobial effectiveness, several procedures were employed to detect whether C14 leaching occurred. An immersion-growth (IG) test was developed that required knowing the bacterial Minimum Inhibitory Concentrations (MICs) and Minimum Biocidal Concentrations (MBCs). The C14 MIC and MBC for Gm– uropathogenic E. coli (UPEC), commonly associated with catheter-associated urinary tract infections (CAUTI), were 10 and 20 μg/mL, respectively. After prior immersion of WG-1 silicone segments in a growth medium from 1 to 28 d, the IG test for the medium showed normal growth for UPEC over 24 h, indicating that the concentration of C14 must be less than the MIC, 10 μg/mL. GC-MS and studies of the medium inside and outside a dialysis bag containing WG-1 silicone segments supported de minimis leaching. Consequently, a 5 log UPEC reduction (99.999% kill) in 24 h using the shake flask test (ASTM E2149) cannot be due to leaching and is ascribed to contact kill. Interestingly, although the MBC was greater than 100 μg/mL for Pseudomonas aeruginosa, WG-1 silicone affected an 80% reduction via a 24 h shake flask test. For other bacteria and Candida albicans , greater than 99.9% shake flask kill may be understood by proposing increased wettability and concentration of charge illustrated in the TOC. De minimis leaching places WG-1 silicone at an advantage over conventional anti-infectives that rely on leaching of an antibiotic or heavy metals such as silver. The facile process for preparation of WG-1 silicone combined with biocidal effectiveness comprises progress toward the goals of device designation from the FDA for WG-1 and clearance.

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In-Office Replacement of Voice Prosthesis

Saraniti,

Verro,

Fiumara

2024

Voice Prosthesis in Total Laryngectomized Patients

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Factors Affecting the Lifetime of Third-Generation Voice Prosthesis After Total Laryngectomy

Cited by 3 publications

References 29 publications

Is Oral Microflora Related to Development of Malfunction in Patients Using Voice Prosthesis?

Is Oral Microflora Related to Development of Malfunction in Patients Using Voice Prosthesis?

Facile Modification of Medical-Grade Silicone for Antimicrobial Effectiveness and Biocompatibility: A Potential Therapeutic Strategy against Bacterial Biofilms

In-Office Replacement of Voice Prosthesis

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