Factors affecting the efficacy of ivermectin against Heligmosomoides polygyrus (Nematospiroides dubius) in mice

Abstract

A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription.For more information, please contact eprints@nottingham.ac.uk Veterinary Parasitology, 32 (1989) The efficacy of ivermectin against Heligmosomoides polygyrus was investigated in 5 mouse strains (CFLP, NIH, C57Bllo, BALB/c and CBA ) using a variety of dose levels, and subcutaneous and oral administration, Heligmosomoides polygyrus were not completely eliminated when 5 mg kg 1 of ivermectin was given 6 days after infection, but 10 mg kg-~ was totally effective. Significant mouse-strain variation in drug efficacy was detected, NIH mice requiring treatment with higher doses than CFLP mice in order to bring about a comparable level of larvicidal activity. Ivermectin was more effective when given subcutaneously than when given orally, regardless of the dose administered or the strain of mouse tested. The anthelmintic effect of the treatment was more persistent in CFLP mice given 20 mg kg-~ subcutaneously than in NIH mice or in mice treated orally, and a 20-day interval between administration and infection was insufficient to prevent inhibition of parasite survival. Ivermectin was shown to be totally effective at 20 mg kg-1 given subcutaneously in killing immune arrested larvae of H. polygyrus.

Bacillus thuringiensis Cry5B Protein Is Highly Efficacious as a Single-Dose Therapy against an Intestinal Roundworm Infection in Mice

“…Another study showed that 2.9 µmoles/kg of ivermectin delivered on day 10 P.I. effected ∼70% reduction in H. bakeri worm burdens [30]. We could not find comparable studies with H. bakeri and benzimidazoles, although we did find that mebendazole delivered for 7 consecutive days, starting day 9 P.I.…”

The mucosal response of hamsters to a low-intensity superimposed secondary infection with the hookworm Ancylostoma ceylanicum

“…Group 3 animals, as the challenge control group, were also treated in case there was a residual effect against the subsequent infection, although none was expected given the 4-week interval to infection (Wahid et al, 1989). Initially three groups (2, 4 and 5) were infected orally with 50 infective larvae of A. ceylanicum on day 0.…”

The role of host sex in parasite dynamics: field experiments on the yellow‐necked mouseApodemus flavicollis

“…The yellow‐necked mouse population was monitored every 2 weeks from February to March, and from the first week of April until the middle of September, we selectively treated adult and subadult individuals with the anthelmintic Ivermectin (Ivomec ® , Merial, Merck Sharp & Dohme, Harlem, Netherlands) by injecting a subcutaneous dose of 10 mg kg −1 (Wahid et al. 1989).…”

“…In a second random group of three trapping grids we treated only males and the three remaining grids were used as controls where no individuals were treated. We assumed that the drug efficacy lasted 11–15 days (Wahid et al. 1989) and as the prepatency period of H. polygyrus from egg to egg was 13–15 days long (Keymer 1985), each individual was treated once a month.…”