Factors Affecting the Determination of the Physical Properties of Femoral Cortical Bone

Sedlin, Elias D.; Hirsch, Carl

doi:10.3109/17453676608989401

Cited by 515 publications

(204 citation statements)

References 10 publications

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“…This procedure has been shown not to affect the mechanical properties of bone. (9,10) Plasma and urine chemistry Plasma and urine creatinine was measured by the kinetic colorimetric assay according to Jaffe, plasma urea was measured by colorimetric enzymatic dry chemistry, and phosphate was measured by colorimetric dry chemistry (Vitros 950 analyzer, Johnson & Johnson Clinical Diagnostics, Rochester, NY, USA). Plasma ionized Ca 2+ and pH were measured by an ion selective electrode (Ciba Corning 634 Ca 2+ /pH Analyzer; Ciba Corning Diagnostics, Sudbury, UK).…”

Section: Data Collection and Samplesmentioning

confidence: 99%

Paricalcitol [19-Nor-1,25-(OH)2D2] in the Treatment of Experimental Renal Bone Disease

Jokihaara

Pörsti

Pajamäki

et al. 2006

Journal of Bone and Mineral Research

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Paricalcitol is a less hypercalcemic vitamin D analog that has been shown to suppress secondary hyperparathyroidism and to prevent the associated histomorphometric changes in bone. In this study, we show that paricalcitol also ameliorates the renal insufficiency-induced loss of bone mineral and the mechanical competence of bone.Introduction: Renal bone disease is a common consequence of chronic renal insufficiency and the associated secondary hyperparathyroidism (SH). Paricalcitol [19-nor-1,25(OH) 2 D 2 ] has been shown to ameliorate SH and prevent renal failure-induced histomorphometric changes in bone with minimal calcemic and phosphatemic activity. However, information about its efficacy on restoration of bone structural strength is lacking. In this study, we explored the effects of paricalcitol treatment on bone structure and strength in a model of advanced renal disease. Materials and Methods: Forty-five 8-week-old rats were randomly assigned to either surgical 5/6 nephrectomy (NTX) or Sham-operation. After a 15-week postoperative disease progression period, the NTX rats were further allocated to uremic control (NTX) and treatment (NTX + paricalcitol) groups, the latter of which received paricalcitol for the subsequent 12 weeks. After 27 weeks, the animals were killed, plasma samples were collected, and both femora were excised for comprehensive analysis of the femoral neck and midshaft (pQCT and biomechanical testing). Results: High mortality that exceeded 30% was observed in both NTX groups. NTX induced over a 13-fold increase in plasma PTH, whereas this increase was only 5-fold after paricalcitol treatment. At the femoral neck, NTX was associated with an 8.1% decrease (p < 0.05) in vBMD and a 16% decrease in breaking load (p < 0.05) compared with the Sham group, whereas paricalcitol treatment completely prevented these changes. At the femoral midshaft, the NTX resulted in a 6.6% decrease in cortical BMD (p < 0.01 versus Sham), and this change was also prevented by paricalcitol. Conclusions: Paricalcitol administration prevented renal insufficiency-associated decreases in BMD in the femoral neck and the femoral midshaft and restored bone strength in the femoral neck. Therefore, paricalcitol can efficiently ameliorate renal insufficiency-induced loss of bone mineral and mechanical competence of bone.

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Section: Data Collection and Samplesmentioning

confidence: 99%

Paricalcitol [19-Nor-1,25-(OH)2D2] in the Treatment of Experimental Renal Bone Disease

Jokihaara

Pörsti

Pajamäki

et al. 2006

Journal of Bone and Mineral Research

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“…Using cadaver femora, the time-consuming preparation for photoelastic studies, the coating, and test series should be completed within 72 h [34,54] . Some authors additionally aim to simulate osteointegration and implant fi xation by bonding or cementation in their experimental studies [6,64] .…”

Section: Discussionmentioning

confidence: 99%

Influence of cementless hip stems on femoral cortical strain pattern depending on their extent of porous coating

Ellenrieder

Steinhauser

Bader

et al. 2012

Biomedizinische Technik/Biomedical Engineering

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“…These specimens, together with 10 human lumbar spine specimens, were screened by X-ray to eliminate visible lesions. All specimens were packaged in plastic film bags and stored at -20 °C until use (Seldin & Hirsch, 1966).…”

Section: Methodsmentioning

confidence: 99%

Morphometry Research of Deer, Sheep, and Human Lumbar Spine: Feasibility of Using Deerand Sheep in Spinal Animal Models

Xiao-fan¹,

Liu²,

Xu³

et al. 2012

Int. J. Morphol.

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SUMMARY:Deer and sheep are used as spinal animal models in clinical and basic research. In this paper, the anatomical morphology, curvature, and morphology index parameters were investigated to assess the feasibility of using deer and sheep as animal models of the human spine. Fresh adult male sheep, deer, and human spine specimens (n = 10 each) were screened and subjected to morphological analyses. The statistical software package SPSS (version 17.0) was used to analyze the statistical similarity and variability among the 3 species. Deer displayed good similarity to human in terms of the vertebral transverse diameter, radius vector, spinal canal transverse diameter, radius vector, and vertebral upper and lower endplate curvature radii. Sheep displayed good similarity to human in terms of the vertebral body height, pedicle height, vertebral mid-lever curvature radius, and vertebral positive curvature radius. Human, deer, and sheep each displayed unique morphological characteristics and trends for the lumbar spine. These findings indicate that deer and sheep are good spinal animal models of human in morphometry, but with specific advantages in different research fields: deer are more suitable when studying vertebrae and endplate structures, while sheep are more suitable when referring to structures such as the vertebral walls.

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Factors Affecting the Determination of the Physical Properties of Femoral Cortical Bone

Cited by 515 publications

References 10 publications

Paricalcitol [19-Nor-1,25-(OH)2D2] in the Treatment of Experimental Renal Bone Disease

Paricalcitol [19-Nor-1,25-(OH)2D2] in the Treatment of Experimental Renal Bone Disease

Influence of cementless hip stems on femoral cortical strain pattern depending on their extent of porous coating

Morphometry Research of Deer, Sheep, and Human Lumbar Spine: Feasibility of Using Deerand Sheep in Spinal Animal Models

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