Bangladesh Ready-Made Garments (RMG) sector shows remarkable growth and significant contribution in the country's economic development though product and service qualities are yet a considerable problem to worry about. RMG companies in Bangladesh are not fully aware about the impacts and value of Total Quality Management (TQM) implementation. Actually they mostly give emphasis on ISO 9000 execution and various researches show that application of this only enhances problems. Researchers argue that effective implementation of TQM practices is a main criteria and predictor of gaining sustainability in business. So, for being competitive in the long run, RMG industry in Bangladesh should focus more on TQM practices rather than taking advantages out of the cheapest labors. As, it is notable to mention that in case of Bangladesh RMG sector, most of the existing literatures give more emphasis and discuss about the infrastructural and strategic matters whereas TQM and Human Resource Management (HRM) practices in an attempt to improve sustainable competitive advantage are still a debate both theoretically as well as empirically. In this aspect, literatures proved that, no previous studies were conducted to verify the association among practices of TQM, sustainable competitive advantage as well as the role of HRM as a mediator to build TQM climate in Bangladesh RMG sector. In order to bridge this gap and to generate a more comprehensive argument, this paper further proposes and aims at providing a tool, a procedural framework, to enhance TQM in various RMG companies operating in Bangladesh via the development of appropriate TQM model which will ensure organizational sustainable competitive advantage where HRM practices will consider as mediating variable. Proposed research direction and conclusion are discussed in conclusion of this research.