Factors affecting the bioadhesive property of tablets consisting of hedroxypropyl cellulose and carboxyvinyl polymer.

Satoh, Kimiko; Takayama, K.; Machida, Yoshiharu; Suzuki, Yuichi; Nakagaki, Masayuki; Nagai, Tsuneji

doi:10.1248/cpb.37.1366

Cited by 58 publications

(31 citation statements)

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“…Whereas CMC was not affected by pH, the polyacrylic acids and carageenan showed maximum rheological synergism at weakly acidic pH values (pH 5.2 for polyacrylic acids ; pH 6.2 for carageenan). Satoh et al (1989) reported an inter-polymer complex between Carbopol 934 and hydroxypropyl cellulose below pH 4.5 due to hydrogen bonding. For effective hydrogen bonding to occur, hydrophilic functional groups such as carboxyl, hydroxyl, amide and sulfate are required.…”

Section: Environment-related Factorsmentioning

confidence: 99%

The biopharmaceutical aspects of nasal mucoadhesive drug delivery

Ugwoke

Verbeke

Kinget

2001

Journal of Pharmacy and Pharmacology

288

153

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Nasal drug administration has frequently been proposed as the most feasible alternative to parenteral injections. This is due to the high permeability of the nasal epithelium, allowing a higher molecular mass cut-off at approximately 1000 Da, and the rapid drug absorption rate with plasma drug profiles sometimes almost identical to those from intravenous injections.Despite the potential of nasal drug delivery, it has a number of limitations. In this review, the anatomy and physiology of the nasal cavity, as well as ciliary beating and mucociliary clearance as they relate to nasal drug absorption, are introduced. The rationale for nasal drug delivery and its limitations, some factors that influence nasal drug absorption, and the experimental models used in nasal drug delivery research are also reviewed. Nasal mucoadhesion as a promising method of nasal absorption enhancement is discussed, and factors that influence mucoadhesion, as well as safety of nasal mucoadhesive drug delivery systems are reviewed in detail.Nasal drug administration is presently mostly used for local therapies within the nasal cavity.

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Section: Environment-related Factorsmentioning

confidence: 99%

The biopharmaceutical aspects of nasal mucoadhesive drug delivery

Ugwoke

Verbeke

Kinget

2001

Journal of Pharmacy and Pharmacology

288

153

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“…The force required to puncture the device for formulations CM-5, CM-6, and CM-7 decreased as polyisobutylene concentration increased from 5 to 30% w/w. Polyisobutylene, a commonly used elastomeric polymer in chewing gum formulations (18)(19)(20)(21)(22), appeared to improve the elasticity of the CM device formulations.…”

Section: Elasticity Evaluationmentioning

confidence: 99%

“…A combination of these two attributes can be achieved by the use of suitable bioadhesive materials (3)(4)(5)(6). Appropriate materials for the bioadhesive drug delivery consist mainly of hydrogel-forming polymers (7,8). They have been called "wet" adhesives because they require moisture to exhibit the adhesive property (9).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of polyoxyethylene homopolymers for buccal bioadhesive drug delivery device formulations

Tiwari¹,

Sause²,

Madan³

et al. 1999

AAPS PharmSci

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Our objective was to evaluate the application of polyoxyethylene homopolymers in buccal bioadhesive drug (BBD) delivery device formulations. The bioadhesive strength of four different molecular weight (MW) polyoxyethylene polymers was measured by Instronâ tensile tester using glass plate and bovine sublingual tissue as substrate surfaces. Several BBD device formulations containing polyoxyethylene polymer (MW 7,000,000) were prepared by direct compression and compression molding processes. The prepared BBD devices were evaluated for their elasticity, in vitro adhesion and drug release characteristics. The in vivo bioadhesion characteristics of a placebo compression molded device were examined in 3 adult healthy male beagle dogs. The bioadhesive strength of polyoxyethylene polymers appeared to be directly related to their molecular weights. When bovine sublingual mucosa or a glass plate was used as model mucosal substrate surface, the rank order of bioadhesive strength of different molecular weight polyoxyethylene polymers was similar. The bioadhesive strength of devices prepared by the compression molding process was greater than those prepared by direct compression, but the kinetics of drug release were independent of the process used for the preparation of the devices. The drug release and the bioadhesive strength of the similarly prepared device formulations appeared to be dependent on the drug:polymer ratios. The elasticity of the BBD devices prepared by compression molding was improved by the inclusion of polyisobutylene polymer in the formulations. When adhered to the oral cavity of the dogs, the compression molded placebo BBD device exhibited adhesion for at least 4 hours and appeared to show no signs of local irritation. In conclusion, BBD devices containing polyoxyethylene polymer (MW 7,000,000) can be prepared by direct compression or compression molding process in order to provide controlled drug release to the oral cavity while maintaining appropriate bioadhesive characteristics.

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“…Such combinations may possess unique properties that are different from those of individual components. A great potential exists in using these blends in many pharmaceutical preparations, especially in controlled release drug delivery systems (Fung-Tan, Peh, and Al-Hanbali 2001;Shojaei 1998;Elgingy and Elegakey 1981;Satoh et al 1989;Takayama et al 1990;Gupta, Garg, and Khar 1994;Anlar et al 1994;Kumar, Yang, and Yang 1999;Ibezim et al 2000). Various methods have been used to investigate interactions among polymers.…”

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confidence: 99%

Polyelectrolyte Complexes of Eudragit L30 D-55 and Gelatin: Antinociceptive Activity of Entrapped Piroxicam

Attama

2007

Drug Delivery

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Factors affecting the bioadhesive property of tablets consisting of hedroxypropyl cellulose and carboxyvinyl polymer.

Cited by 58 publications

References 0 publications

The biopharmaceutical aspects of nasal mucoadhesive drug delivery

The biopharmaceutical aspects of nasal mucoadhesive drug delivery

Evaluation of polyoxyethylene homopolymers for buccal bioadhesive drug delivery device formulations

Polyelectrolyte Complexes of Eudragit L30 D-55 and Gelatin: Antinociceptive Activity of Entrapped Piroxicam

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