Factors affecting the aluminium content of human femoral head and neck

Zioła-Frankowska, Anetta; Dąbrowski, Mikołaj; Kubaszewski, Łukasz; Rogala, Piotr; Frankowski, Marcin

doi:10.1016/j.jinorgbio.2015.08.019

Cited by 16 publications

(12 citation statements)

References 33 publications

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“…In the present study, we concluded that the differences which we noticed could be related with the type of bone tissues (cancellous bone from the femoral head and cortical bone from the femoral neck) and the site from where the tissue was harvested. The same finding was obtained for the analysis of aluminum in the femoral head and neck (Zioła-Frankowska et al 2015b). Also, it is known that in the formation of cortical and cancellous bones, individual osteons which are separated by cement lines are involved.…”

Section: Discussionsupporting

confidence: 79%

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An analysis of factors affecting the mercury content in the human femoral bone

Zioła-Frankowska

Dąbrowski

Kubaszewski

et al. 2016

Environ Sci Pollut Res

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The study was carried out to determine the content of mercury in bone tissue of the proximal femur (head and neck bone) of 95 patients undergoing total hip replacement due to osteoarthritis, using CF-AFS analytical technique. Furthermore, the investigations were aimed at assessing the impact of selected factors, such as age, gender, tobacco smoking, alcohol consumption, exposure to chemical substance at work, type of degenerative changes, clinical evaluation and radiological parameters, type of medications, on the concentration of mercury in the head and neck of the femur, resected in situ. Mercury was obtained in all samples of the head and neck of the femur (n = 190) in patients aged 25-91 years. The mean content of mercury for the whole group of patients was as follows: 37.1 ± 35.0 ng/g for the femoral neck and 24.2 ± 19.5 ng/g for the femoral head. The highest Hg contents were found in femoral neck samples, both in women and men, and they amounted to 169.6 and 176.5 ng/g, respectively. The research showed that the mercury content of bones can be associated with body mass index, differences in body anatomy, and gender. The uses of statistical analysis gave the possibility to define the influence of factors on mercury content in human femoral bones.

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Section: Discussionsupporting

confidence: 79%

“…Detailed and accurate information about characteristics of patients and femoral bone samples are presented in the studies by Zioła-Frankowska et al (2015a, b). …”

Section: Methodsmentioning

confidence: 99%

An analysis of factors affecting the mercury content in the human femoral bone

Zioła-Frankowska

Dąbrowski

Kubaszewski

et al. 2016

Environ Sci Pollut Res

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“…Firstly, Al accumulation is the premise. It is reported that Al accumulates in the femoral head samples from patients under and over 60 years of age (Ziola-Frankowska et al, 2015), and the 21/30 patients with exostosis (Chappard et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Ginsenoside Rb1 alleviates aluminum chloride-induced rat osteoblasts dysfunction

Zhu

Zheng

et al. 2016

Toxicology

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Osteoblasts dysfunction, induced by aluminum (Al), plays a critical role in the osteoporosis etiology. Ginsenoside Rb1 (Rb1) has the therapeutic properties for osteoporosis. This study aimed to assess the efficiency of Rb1 in ameliorating Al-induced osteoblasts dysfunction. The osteoblasts were divided into four groups: Rb1-treated group (RG, 0.0145mg/mL Rb1), control group (CG, 0), AlCl-treated group (AG, 0.126mg/mL AlCl·6HO), AlCl+Rb1-treated group (ARG, 0.0145mg/mL Rb1 and 0.126mg/mL AlCl·6HO). After 24h of culture, the osteoblasts viability, the transforming growth factor-β1 (TGF-), bone morphogenetic protein-2 (BMP-2), the insulin-like growth factor I (IGF-I), core-binding factor α1 (Cbfα1) mRNA expressions, glutathione perioxidase (GSH-P and superoxide dismutase (SOD) activities, and reactive oxygen species (ROS) concentration were determined. The osteoblasts ultrastructural features were also observed. In the ARG, the osteoblasts viability, TGF-, BMP-2, IGF-I and Cbfα1 mRNA expressions and the GSH-P and SOD activities were significantly increased, the ROS concentration was significantly decreased, and osteoblasts histology lesion was attenuated compared with the AG. These results demonstrated that Rb1 could significantly reverse osteoblasts viability and osteoblasts growth regulation factor, inhibit oxidative stress, and attenuate histology lesion in the osteoblasts with AlCl. These results indicate that Rb1 can effectively alleviate the AlCl-induced osteoblasts dysfunction.

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“…Then, samples with acid were left to stand overnight to slow mineralization. After this step, samples were mineralized in a microwave oven (Mars Xpress 5, CEM USA), based on the modified 3051 EPA method (Zioła-Frankowska et al 2015 , 2016 ). In the case of Si, 200 μL of 1% supra-pure hydrofluoric acid (Merck, Germany) was added to the extracts of IVD tissues to prevent the precipitation of silicon in an acid medium.…”

Section: Methodsmentioning

confidence: 99%

Interrelationship between silicon, aluminum, and elements associated with tissue metabolism and degenerative processes in degenerated human intervertebral disc tissue

Zioła-Frankowska

Kubaszewski

Dąbrowski

et al. 2017

Environ Sci Pollut Res

Self Cite

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There is a growing body of evidence concerning the significant role of silicon in development and composition of both connective and bone tissue. Bio-essential silicon shows strong chemical and biological affinity to aluminum, which is toxic and biologically inessential element. The presence of silicon was confirmed in a variety of tissues; however, it has never been examined in intervertebral disc tissue, neither in healthy nor in degenerated one. In this paper, for the first time in the literature, we present the content of silicon in the degenerated intervertebral disc tissue. We also compared the results of silicon analysis with aluminum values in degenerated intervertebral disc tissue in humans. We used chemometric methods to find correlations and similarities between silicon, aluminum, and elements associated with tissue metabolism (Mg) and degenerative processes (Zn and Cu). The presence of silicon was confirmed in all 30 samples harvested from 22 patients operated on due to degenerative changes. Its concentration was within the range of 5.37–12.8 μg g−1 d.w., with the mean concentration of 7.82 μg g−1 d.w. The analysis showed significant correlation between Si and both Al and Mg and weak or negative correlation with Zn and Cu, where the latter was probably the result of degenerative processes. Although silicon is considered essential in glycosaminoglycan and collagen synthesis in connective tissue, it did not show any correlation nor similarities with elements reflecting changes associated with the degenerative process of the intervertebral disc. Silicon showed significant correlation with aluminum, similar to those observed in other human tissues.

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Factors affecting the aluminium content of human femoral head and neck

Cited by 16 publications

References 33 publications

An analysis of factors affecting the mercury content in the human femoral bone

An analysis of factors affecting the mercury content in the human femoral bone

Ginsenoside Rb1 alleviates aluminum chloride-induced rat osteoblasts dysfunction

Interrelationship between silicon, aluminum, and elements associated with tissue metabolism and degenerative processes in degenerated human intervertebral disc tissue

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