Factors Affecting the Absorption of Riboflavin in Man

Levy, Gerhard; Jusko, William J.

doi:10.1002/jps.2600550305

Cited by 157 publications

(53 citation statements)

References 21 publications

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“…The absorption of riboflavin from foods takes place predominantly in the small intestine through an active carrier-mediated transport process (17,24,41). In addition, carrier-mediated absorption in the colon is thought to be important, because riboflavin is synthesized by bacterial metabolism in the colon (21,44).…”

Section: Discussionmentioning

confidence: 99%

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Identification and functional characterization of a novel human and rat riboflavin transporter, RFT1

Yonezawa¹,

Masuda²,

Katsura³

et al. 2008

American Journal of Physiology-Cell Physiology

128

101

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Section: Discussionmentioning

confidence: 99%

“…In vivo, in situ, and membrane vesicle experiments have elucidated the predominant role of carrier-mediated absorption in the intake of riboflavin by the small intestine and colon (4,7,17,21,24,34,41,44). In addition, the subject of riboflavin excretion has gained increasing attention.…”

mentioning

confidence: 99%

Identification and functional characterization of a novel human and rat riboflavin transporter, RFT1

Yonezawa¹,

Masuda²,

Katsura³

et al. 2008

American Journal of Physiology-Cell Physiology

128

101

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“…In man a few drugs, such as levodopa, otmethyldopa, riboflavin, amino-,B-lactam antibiotics and ACE-inhibitors are believed to utilize these transport systems. In animal studies these drugs have been shown to be actively transported across the intestinal mucosa Hu & Amidon, 1988;Kimura et al, 1978;Levy & Jusko, 1966;Wade et al, 1973).…”

mentioning

confidence: 99%

The effect of L‐leucine on the absorption of levodopa, studied by regional jejunal perfusion in man.

Lennernäs

Nilsson

et al. 1993

Brit J Clinical Pharma

105

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1. A new method for perfusing a 10 cm segment of jejunum in humans has been used in seven subjects to study the effect of the amino acid L‐ leucine (40 mM) on the intestinal absorption of levodopa (2.5 mM). The tube contains six channels and has two inflatable balloons, which enable a perfusion of a closed and defined segment of the proximal small intestine. 2. L‐leucine decreased the intestinal absorption of levodopa from 40 +/‐ 19 to 21 +/‐ 15% but was without effect on the absorption of antipyrine, benserazide and D‐glucose. 3. We confirm that levodopa is absorbed by the active transport system normally responsible for the absorption of large neutral amino acids (LNAA) in humans. Oral absorption by passive diffusion, probably by the paracellular route, might also occur for levodopa in the proximal part of the small intestine.

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“…Gastro-retentive DDSs exhibiting controlled drug release are significantly important for drugs which are: Acting locally in the stomach (e.g. antibiotics against Helicobacter Pylori, antacids and misoprostol) [15][16][17][18][19].Absorbed incompletely due to a relatively narrow window of absorption in the GIT, such as cyclosporin, ciprofloxacin, furosemide, L-DOPA, p-aminobenzoic acid and riboflavin [3,[20][21][22][23][24][25].Unstable in the intestinal or colonic environment such as captopril [26] or exhibit low solubility at high pH values such as verapamil HCl, diazepam and chlordiazepoxide [27][28][29][30]. Polymers are principle excipient in pharmaceutical dosage forms especially with modified release.…”

Section: Introductionmentioning

confidence: 99%

Formulation and evaluation of Gastro-retentive drug delivery system using Fenugreek gum as novel matrixing agent

Khobragade¹,

Reddy²,

Kumar³

et al. 2016

Int J of Adv in Sci Res

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The purpose of this study was to evaluate efficiency of fenugreek gum for developing gastro retentive floating tablets of Sumatriptan succinate when used alone or in combination with established polymers. The floating Tablet were prepared by direct compression and wet granulation technique and evaluated for various parameters like physical characterization, hardness, friability, weight variation, drug content uniformity, swelling index and in-vitro buoyancy and drug release. Fenugreek gum was efficient as release retardant and floating agent when used alone or in combinations with HPMC. The results indicated that fenugreek gum effectively sustained release for 12 hrs with parameters such as floating lag time, buoyancy, and floating time in acceptable range. In-vitro drug release kinetics evaluated using the linear regression method was found to follow the Higuchi release kinetics equation. This suggests that fenugreek gum can be a novel hydrophilic polymer in designing of FDDS.

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Factors Affecting the Absorption of Riboflavin in Man

Cited by 157 publications

References 21 publications

Identification and functional characterization of a novel human and rat riboflavin transporter, RFT1

Identification and functional characterization of a novel human and rat riboflavin transporter, RFT1

The effect of L‐leucine on the absorption of levodopa, studied by regional jejunal perfusion in man.

Formulation and evaluation of Gastro-retentive drug delivery system using Fenugreek gum as novel matrixing agent

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