Factors affecting the 27K DNA methylation pattern in asthmatic and healthy children from locations with various environments

Characteristic DNA methylation profiles in peripheral blood monocytes are associated with inflammatory phenotypes of asthma

“…Therefore, abnormal expression of inflammatory cytokines, a characteristic feature of asthma, may be a consequence of these methylation events. Indeed, recent studies confirmed the role of different environmental conditions on DNA methylation 13 and association of such modifications in the pathogenesis of asthma. [14][15][16][17] The genome-wide DNA methylation profiling of whole blood or PBMCs facilitated the identification of many altered gene loci.…”

Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylation

“…It is the potentially reversible addition of a methyl group to DNA cytosine residues, primarily where a cytosine is followed directly by a guanine (CpG sites) 14 . Consistent with epigenetics serving as a potential mediator between environment and genome, differential DNA methylation of a number of genes involved in multiple cellular processes including immune responses [15][16][17] , nitric oxide synthesis 18,19 , and DNA binding 16 , has been associated with air pollution exposure. We have previously shown controlled exposure to DE alters the methylation of CpG sites in circulating mononuclear cells 20 .…”

The Neonatal Methylome as a Gatekeeper in the Trajectory to Childhood Asthma

“…Diesel exhaust Air pollution, and more specifically diesel exhaust particles, are known to be associated with both risk for asthma and allergy [44] and changes in DNA methylation profiles [45][46][47]. Recent work assessed how in vivo exposure to diesel exhaust (through a dedicated apparatus) and allergen (through challenge within the lung) affects DNA methylation in human epithelial cells obtained by bronchoscopy.…”