Factors affecting survival of hospitalised patients with COPD

Abstract

Factors determining in-hospital mortality and long-term survival of patients hospitalised with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are not precisely understood. The aim of the present study was to assess the parameters related to in-hospital mortality and long-term survival after hospitalisation of patients with AECOPD.Clinical and epidemiological parameters on admission in 205 consecutive patients hospitalised with AECOPD were prospectively assessed. Patients were followed-up for 3 yrs. Factors determining short-and long-term mortality were analysed.In total, 17 patients (8.3%) died in hospital. In-hospital mortality was significantly associated with lower arterial oxygen tension (Pa,O 2 ), higher carbon dioxide arterial tension, lower arterial oxygen saturation and longer hospital stay. The overall 6-month mortality rate was 24%, with 1-, 2-and 3-yr mortality rates of 33%, 39% and 49%, respectively. Cox regression analysis revealed that long-term mortality was associated with longer disease duration (relative risk (RR)51.158), lower albumin (RR50.411), lower Pa,O 2 (RR50.871) and lower body mass index (RR50.830). When the model was run for the time elapsed since first hospitalisation, it also appeared as statistically significant (RR51.195).These findings show that patients hospitalised with acute exacerbations of chronic obstructive pulmonary disease have poor short-and long-term survival. Prediction of survival status may be enhanced by considering arterial oxygen tension, albumin, body mass index, disease duration and time elapsed since the first hospitalisation.

Analysis of protein-protein interaction network in chronic obstructive pulmonary disease

“…The interactive genes of ALB are LDB3 and ATG10, which are involved in metabolic and cellular processes. A report showed that when considering ALB in the prediction of survival status, the survival of patients hospitalized with acute exacerbations of COPD may be enhanced (Gunen et al, 2005).…”

Mortality and factors affecting mortality in chronic obstructive pulmonary disease

“…KO-AH mortalitesiyle ilgili yapılmış araştırmaların, genellikle alevlenme nedeniyle hastaneye yatan, uzun süreli oksijen tedavisi kullanan, daha düşük FEV 1 değerlerine sahip, ağır ve çok ağır evre KOAH'lı olguları kapsadığı görülmektedir. Genellikle 3-5 yıllık mortalite oranları-nın verildiği bu araştırmalarda mortalite oranlarının %15-54 arasında değiştiği görülmektedir (6,9,(15)(16)(17)(18)(19). Mortalite oranlarındaki yüksekliğin, çalışmalara katılan olguların alevlenme nedeniyle hastaneye yatan ya da düşük FEV 1 değerine sahip olgulardan kaynaklandığı söylenebilir.…”

“…Mortalite oranlarındaki yüksekliğin, çalışmalara katılan olguların alevlenme nedeniyle hastaneye yatan ya da düşük FEV 1 değerine sahip olgulardan kaynaklandığı söylenebilir. Örneğin; Coleta ve arkadaşlarının yaptığı çalışmada saptanan %15.4'lük bir yıllık mortalite oranı da uzun süreli oksijen tedavisi alan olgulara ait bir sonuçtur (6,15,16,(18)(19)(20). Çalışma grubumuzdaki olgular çoğunlukla hafif ve orta evre KOAH'lılardan oluşmakla birlikte bu çalışmalarla kıyaslanabilir bir mortalite oranından bahsedilebilir.…”

Is it possible to improve prognosis in patients with chronic obstructive pulmonary disease?

“…Госпитальная ле тальность у пациентов, поступивших в стационар с обострением ХОБЛ, проявляющимся гиперкап Обзоры нией с ацидозом, составляет ≈ 10 % [39]. Через 1 год после выписки у пациентов, которым требовалось респираторная поддержка, летальность достигает 40 %, а смертность от всех причин через 3 года после госпитализации составляет 49 % [40][41][42].…”