Factors affecting survival in patients with oral cancer: an Australian perspective

Chandu, Arun; Adams, Geoff; Smith, Andrew C.

doi:10.1016/j.ijom.2004.10.006

Cited by 79 publications

(68 citation statements)

References 35 publications

(47 reference statements)

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“…It is difficult to compare our outcomes directly with others because of variations in patient characteristics, treatment modality and report of outcome data. The 2-year and 3-year survival rates in this study were 38% and 26%, very much lower compared with other studies using surgery (Chandu et al, 2005;Rogers et al, 2009). This finding may be due to higher percentage of the patients with advanced stages in this study compared to the other studies.…”

Section: A) B) C) D) E) F)contrasting

confidence: 79%

“…Also, the association between sex and survival is controversial. In some reports there is no difference between male and female patients (Chandu et al, 2005;Montoro et al, 2008) whereas in some others male patients have lower survival (Yeole et al, 2003;Oliveira et al, 2008). In the present study survival between male and female gender was not significant (p=0.74).…”

Section: A) B) C) D) E) F)contrasting

confidence: 72%

“…In Australia an overall survival rate of 83.3% has been reported (Chandu, 2005). In United Kingdom the 5-year overall survival was 64% (Woolgar et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Survival Following Non Surgical Treatments for Oral Cancer: a Single Institutional Result

Larizadeh

Shabani²

2012

Asian Pacific Journal of Cancer Prevention

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Section: A) B) C) D) E) F)contrasting

confidence: 79%

Section: A) B) C) D) E) F)contrasting

confidence: 72%

See 1 more Smart Citation

Survival Following Non Surgical Treatments for Oral Cancer: a Single Institutional Result

Larizadeh

Shabani²

2012

Asian Pacific Journal of Cancer Prevention

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“…Margin involvement independently increases relative mortality risk, with studies variably reporting relative risk from 2 to 16 times, and close margins of 5mm or less increases risk from 1.3 to 2.6 times [215][216][217][218][219]. Importantly, a clear surgical margin is a generally favourable factor and commonly influences clinical decision-making for recommendation of adjuvant treatment, and therefore is of great interest for…”

Section: (C) Margin Involvementmentioning

confidence: 99%

“…In particular, high RNF8 expression seems associated with nodal metastasis and extranodal spread. As mentioned previously, oral cavity cancer has high and early occult metastatic rate [6], and severe (grade 4) extracapsular spread is associated with significantly increased locoregional recurrence and lower overall survival [217,224]. Biomarker-based identification of tumours with a nodal metastatic tendency at an early biopsy stage would be invaluable for clinical decision-making and treatment recommendation.…”

Section: Section 503 Associated Findingsmentioning

confidence: 99%

Individualising care of tongue cancer using markers of genomic stability

Jenkins¹

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Treatment outcomes and prognostic accuracy for oral tongue cancer has had little substantial improvement in the last 20 years. Adjuvant therapy toxicity is high, and there are no clinical tests that accurately stratify which high-risk cancers are likely to benefit, and which will recur despite treatment. Genomic instability is an inherent force in all cancer, however there are substantial differences in which defective repair pathways cause malignancy and contribute to invasion and metastasis.Tongue cancer is relatively aetiologically homogenous, as it is associated mostly with tobacco exposure, exhibits early lymphatic invasion, and is sensitive to particular DNA-damaging agents, making it an attractive disease target for investigating the prognostic potential of genomic stability markers. The aim of this study is to evaluate the prognostic and predictive implications of genomic instability in primary oral tongue cancer.Molecular tumour diagnostics is a burgeoning field, complicated by a paucity of wellpowered trials demonstrating clinical outcomes. DNA repair proteins as biomarkers have been mostly studied in genetic assays, from severe repair syndrome phenotypes to BRCA gene inactivation in breast and ovarian cancer. De-novo mutations in repair genes have been less frequently characterized across sporadic or exposure-related cancers. Almost all cancers exhibit mutation of nuclear DNA resulting in deregulation of the cell cycle and repair process. The most deleterious lesion is the double-strand break (DSB), and defects in this repair pathway cause both increased aggressive features (heterogeneity, invasion and metastasis) and sensitivity to chemoradiotherapy. This study will examine eight markers of genomic stability across three principal domains;1. Markers of repair of specific lesions induced by standard chemotherapy for oral tongue cancer (treatment prediction) 2. Markers implicated in genetic susceptibility studies in oral squamous cell cancer (phenotype stratification) 3 3. Markers of the DNA damage response and DSB repair (genomic stability)A key study strategy is the creation and utilisation of a tissue microarray resource to economically assess the relatively large number of markers in the context of limited source tissue. A microarray of fifty-five (55) included patients was constructed from stored surgical specimen blocks. Immunohistochemical stains were performed, and grading scales constructed under the guidance of a clinical pathologist (Dr Duncan Lambie).The hypothesis of this study is that genomic instability of primary tumours is a characteristic that is important for both prognosis and treatment prediction, and that this can be quantified using immunohistochemical methods. We have identified two important patient subgroups that show significant prognostic differentiation in our markers and discuss the implications for clinical management. I acknowledge that an electronic copy of my thesis must be lodged with the University Library and, subject to the policy and procedures of The Univ...

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Compliance with quality assurance measures in patients treated for early oral tongue cancer

Hessel

Moreno

Hanna

et al. 2010

Cancer

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BACKGROUND: The objective of this study was to identify measurable parameters that provide quality data for assessing how well cancer care adheres to accepted treatment guidelines and is delivered to any given patient with oral tongue cancer. METHODS: Retrospective chart review of 116 patients treated for T1-T2/N0-N1 squamous cell carcinoma of the oral tongue (SCCOT) between 1998 and 2003. A set of quality measures considered critical for outcome included: 1) accurate tumor-nodal-metastasis (TNM) staging at presentation, 2) documentation of margin status, 3) appropriate referral for adjuvant radiation therapy, and 4) neck dissection for depth of invasion greater than 4mm. Additionally, 26 clinical endpoints involving pretreatment assessment and staging, treatment, and surveillance and symptom control were analyzed. RESULTS: There were 73 male and 43 female patients (median age, 57 years). Forty-one patients (35.3%) presented with stage I disease, 61 (52.6%) with stage II, and 14 (12.1%) with stage III. The overall 5-year survival rate for all patients was 68.6%. There was a 90.5% compliance with TNM staging at presentation, 99.1% for documentation of margin status, 98.2% for adequate referral to radiation therapy, and 88.7% for appropriate neck dissection based on depth of invasion. Compliance with clinical endpoints was variable and ranged from 100% for endpoints related to radiation therapy to less than 40% for endpoints related to speech pathology and rehabilitation. CONCLUSION: Overall compliance with documenting the 4 parameters designated as quality measures for treatment of SCCOT was acceptable thus demonstrating that it is possible to utilize this data for measuring effective cancer care.

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Factors affecting survival in patients with oral cancer: an Australian perspective

Cited by 79 publications

References 35 publications

Survival Following Non Surgical Treatments for Oral Cancer: a Single Institutional Result

Survival Following Non Surgical Treatments for Oral Cancer: a Single Institutional Result

Individualising care of tongue cancer using markers of genomic stability

Compliance with quality assurance measures in patients treated for early oral tongue cancer

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