Factors Affecting Survival in Allogeneic Bone Marrow Transplantation

Interactions between an anticancer drug – edelfosine – and cholesterol in Langmuir monolayers

“…Edelfosine has been applied in vitro against human fibrosarcomas [1] and lung/breast cancer [1,[3][4][5]. Also clinical research on patients with acute leukemia show that edelfosine is a very promising agent in purging bone marrow before autologous transplantations [2,6,7]. It is also known for its antiviral [2] and antiparasitic activity [2,8].…”

Cyclosporin

“…Several of these evaluations confirmed that prophylaxis with cyclosporin plus methotrexate was associated with lower rates and/or severity of acute GVHD than prophylaxis with cyclosporin or methotrexate monotherapyJloo. [134][135][136][137][138][139][140][141][142][143][144][145][146][147][148][149] Some studies also demonstrated statistically significant differences between treatment groups for actuarial survival, DFS, chronic GVHD and/or incidence of interstitial pneumonia favouring the combined regimen, at least in some patient groups,lIOO.136. [144][145][146][147] For example, a large retrospective evaluation of 1902 adults and 384 children who received BMT from HLA-matched sibling donors demonstrated similar outcomes between treatment groups among children; however, the prophylactic regimen did affect outcomes in adult patients.[loo.…”