Factors affecting stem cell mobilization for autologous hematopoietic stem cell transplantation

Özkurt, Zübeyde Nur; Yeğin, Zeynep Arzu; Suyanı, Elif; Aki, Şahika Zeynep; Acar, Kadir; Yağcı, Münci; Sucak, Gülsan Türköz

doi:10.1002/jca.20246

Cited by 47 publications

(43 citation statements)

References 29 publications

(43 reference statements)

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“…Several studies carried out to investigate this question showed that the diagnosis of lymphoma, [14][15][16][17][18][19] thrombocytopenia, 14,[20][21][22][23] older age [18][19][20][21][23][24][25] and polytreatment 14,16,19,25,26 , among other factors, emerged as the main potential factors for the prediction of poor recruitment of hematopoietic stem cells.…”

Section: Predictive Factors Of Poor Mobilizationmentioning

confidence: 99%

Mobilization of hematopoietic progenitor cells for autologous transportation: consensus recommendations

Duarte

Prado²,

Vieira

et al. 2016

Rev. Assoc. Med. Bras.

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SUMMARY Selected patients with certain hematological malignancies and solid tumors have the potential to achieve long-term survival with autologous hematopoietic progenitor cell transplant. The collection of these cells in peripheral blood avoids multiple bone marrow aspirations, results in faster engraftment and allows treatment of patients with infection, fibrosis, or bone marrow hypocellularity. However, for the procedure to be successful, it is essential to mobilize a sufficient number of progenitor cells from the bone marrow into the blood circulation. Therefore, a group of Brazilian experts met in order to develop recommendations for mobilization strategies adapted to the reality of the Brazilian national health system, which could help minimize the risk of failure, reduce toxicity and improve the allocation of financial resources.

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Section: Predictive Factors Of Poor Mobilizationmentioning

confidence: 99%

Mobilization of hematopoietic progenitor cells for autologous transportation: consensus recommendations

Duarte

Prado²,

Vieira

et al. 2016

Rev. Assoc. Med. Bras.

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“…(8)(9)(10)(11)(12)(13). Ozkurt et al showed that poor mobilization frequency was higher in lymphoma patients (14). In our previous study, we have identified a diagnosis of lymphoma was a risk (odds ratio [OR] = 6.02, p = 0.001) factor (15).…”

Section: Introductionmentioning

confidence: 77%

“…The patients were treated with chemotherapy with (14 patients) or without (43 patients) radiotherapy. The median number of the chemotherapy cycles is 9 (range [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] and the median of the number of the chemotherapy regimens is 2 (range 1-5). The number of the patients who were treated with rituximab was 27.…”

Section: Discussionmentioning

confidence: 99%

Lenfoma hastalarında yetersiz hematopoiteik kök hücre mobilizasyonu için risk faktörleri

Tombuloğlu¹,

Dönmez²

2017

Ege Tıp Dergisi

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Aim: Poor mobilization is an important problem in autologous stem cell transplantation. The ratio of poor mobilization is higher in lymphoma patients. There is limited data about poor mobilization in lymphoma patients. We aimed to identify the possible risk factors for poor mobilization using data from 57 lymphoma patients. Materials and Methods:We retrospectively reviewed the data of 57 lymphoma patients (40 with non-Hodgkin lymphoma and 17 with Hodgkin lymphoma) who have been mobilized during 1998 -2011. Patient data were recruited from the archives of the hematology clinic. Results:We documented poor mobilization in 13 (22.8%) patients. Bone marrow involvement (odds ratio [OR] =15.52, p=0.002) and being treated with more than ten cycles of chemotherapies (OR=6.25, p=0.04) were found to be possible risk factors. Conclusion:Leukapheresis staff should be aware of the increased risk of poor mobilization in these cases and remobilization strategies should be considered from the beginning in these patients with risk factors for more effective resource utilization.Keywords: Hematopoietic stem cell mobilization, lymphoma, poor mobilization, risk factors. Öz

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“…Other studies describe that mobilization failure is more common in patients with thrombocytopenia, neutropenia, anemia, leukopenia. 5,9,10 …”

Section: Discussionmentioning

confidence: 99%

Stem Cell Mobilization and Harvesting Failure in Case of Heavily Pretreated Patients

Mild¹,

Lázár

Köpeczi³

et al. 2017

Journal of Interdisciplinary Medicine

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Background: High-dose chemotherapy and autologous stem cell transplantation have become a standard curative treatment in various hematologic malignancies. Many factors can affect the success of mobilization and hematopoietic stem cell harvesting. Aim: The aim of this study was to analyze factors that lead to mobilization failure. Material and Methods: We conducted a retrospective study on 19 patients with failure of stem cell harvesting. All patients were administered high doses of GCS-F (filgrastim, 15 μg/kg/day) and 0.24 mg/kg of plerixafor on day +5 or +10 of harvesting. Results: The median age of the study population was 51 years (range 35-67) and 52.6% (n = 10) were males. The study group included 4 (21%) subjects with multiple myeloma, 6 (31.5%) with Hodgkin lymphoma, 8 cases (42.1%) with nonHodgkin lymphoma and 1 patient with chronic lymphocytic leukemia. Each patient received 2.78 (range 1-5) lines of chemotherapy, administered in 11.57 (range 2 to over 20) cycles of treatment. Conclusion: In hematologic malignancies it is very important to collect stem cells in time, in order to reduce mobilization failure. As we have shown in our studied cases, multiple lines of polychemotherapy with or without radiotherapy lead to mobilization failure.

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Factors affecting stem cell mobilization for autologous hematopoietic stem cell transplantation

Cited by 47 publications

References 29 publications

Mobilization of hematopoietic progenitor cells for autologous transportation: consensus recommendations

Mobilization of hematopoietic progenitor cells for autologous transportation: consensus recommendations

Lenfoma hastalarında yetersiz hematopoiteik kök hücre mobilizasyonu için risk faktörleri

Stem Cell Mobilization and Harvesting Failure in Case of Heavily Pretreated Patients

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