Factors Affecting Selenium Status in Infants on Parenteral Nutrition Therapy

Rao, Anita; Jericho, Hilary; Patton, Tiffany; Sriram, Sudhir; Hebert, Taylor; Weinstein, Dana; Pompeii-Wolfe, Cecelia; Wroblewski, Kristen; Sentongo, Timothy

doi:10.1097/mpg.0000000000003174

Cited by 7 publications

(4 citation statements)

References 41 publications

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“…Similarly, many other studies have reported lower blood selenium level in preterm infants than term infants [10,11,23]. Another study showed more frequent selenium deficiency in extremely low birth weight infants and very low birth weight infants compared to normal birth weight infants [24].…”

Section: Preterm Infantsmentioning

confidence: 68%

Selenium deficiency and supplementation in infants: a narrative review

Lee

Kang

Kim

et al. 2023

Ann Clin Nutr Metab

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Purpose: This review aims to provide an overview of the factors and clinical outcomes associated with selenium deficiency and the guidelines on the optimal selenium supplementation in infants. Current concept: Selenium is a cofactor required to maintain the activity of glutathione peroxidase and is an essential trace element in the human body. Selenium is involved in many stages of oxidative injury within the human body. In severe cases, selenium deficiency may lead to cardiomyopathy. Particularly in infants, the risk factors for selenium deficiency are preterm birth and long-term parenteral nutrition. Several studies have been conducted on the relationship between selenium deficiency and bronchopulmonary dysplasia, retinopathy of prematurity, and sepsis, all of which are common diseases in preterm infants. In the past, 2-3 mcg/kg/day of intravenous selenium supplementation was recommended in preterm infants with selenium deficiency. However, recent studies have suggested that only 2-3 mcg/kg/day can prevent further decreases of selenium level in the blood of preterm infants, and that higher supplementation of 1.5-4.5 mcg/kg/day or 7 mcg/kg/day is necessary to reach the level of healthy infants at term. The recommended dose of selenium through enteral nutrition for preterm infants is 1.3-4.5 mcg/kg/day or 5-10 mcg/kg/day, depending on the guideline. Conclusion: Adequate selenium administration is required for adequate nutritional support in infants to prevent selenium deficiency, and more studies should be conducted to establish dosing guidelines considering risk factors in preterm infants.

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Section: Preterm Infantsmentioning

confidence: 68%

Selenium deficiency and supplementation in infants: a narrative review

Lee

Kang

Kim

et al. 2023

Ann Clin Nutr Metab

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“…11 ELBWIs have a higher risk of selenium deficiency because they tend to have shorter GA, feeding intolerance, and slow increases in enteral nutrition (EN). 18 Recently, Rao et al 27 reported that the odds of selenium deficiency were higher in ELB-WIs (odds ratio = 17.84, 95% CI [4.04-78.72]; P <.001) compared with reference birth weight infants. In this study, GA (P = .096), birth weight (P = .131), and the proportion of ELBWIs (P = .053) in both groups were not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Effect of selenium‐free parenteral nutrition on serum selenium of neonates and infants maintained on long‐term parenteral nutrition

Lee

Shin

Bae

et al. 2021

J Parenter Enteral Nutr

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Background:The risk of selenium deficiency increases for infants receiving long-term parenteral nutrition (PN). This study analyzed selenium deficiency in neonates and infants requiring long-term PN and evaluated the effect of intravenous (IV) selenium provision. Methods:This study was a retrospective study of neonates and infants who were admitted to a neonatal intensive care unit from January 2010 to December 2019, received PN for ≥2 weeks, and had their serum selenium concentration measured.Patients were divided into two groups, depending on their serum selenium concentration, a deficient group (n = 55) and a nondeficient group (n = 47).Results: Of the study participants, 53.9% (55 of 102) were deficient in selenium. No difference in demographic and clinical characteristics existed except bronchopulmonary dysplasia. A subgroup analysis was performed for patients (n = 29). The average dose of IV selenium administered to patients was 2.7 ± 1.0 mcg/kg/day. The average initial serum selenium concentration was 36.5 ± 18.0 mcg/L, and the serum concentration significantly increased to 52.5 ± 19.1 mcg/L after IV selenium administration (P < .001).The correlation between the average IV selenium dose and the change in serum selenium concentrations was statistically significant (r = .423; P = .022). Conclusion:Selenium deficiency is common in neonates and infants receiving longterm PN. Serum selenium concentration increased proportionally as the IV selenium dose increased. Therefore, it is recommended to supply a proper dose of IV selenium depending on the degree of selenium deficiency.

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“…In particular, the symptoms of this disease were reversed in patients receiving Se supplements as parenteral nutrition (intravenous injections) [ 63 ]. Se-containing food supplements are currently considered as an integral part of parenteral nutrition [ 64 , 65 ].…”

Section: Effects Of Selenium Deficiency and Excess On Human Organismmentioning

confidence: 99%

Selenium Metabolism and Biosynthesis of Selenoproteins in the Human Body

Minich

2022

Biochemistry Moscow

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As an essential trace element, selenium (Se) plays a tremendous role in the functioning of the human organism being used for the biosynthesis of selenoproteins (proteins containing one or several selenocysteine residues). The functions of human selenoproteins in vivo are extremely diverse. Many selenoproteins have an antioxidant activity and, hence, play a key role in cell antioxidant defense and maintenance of redox homeostasis, which accounts for their involvement in diverse biological processes, such as signal transduction, proliferation, cell transformation and aging, ferroptosis, immune system functioning, etc. One of the critical functions of selenoenzymes is participation in the synthesis of thyroid hormones regulating basal metabolism in all body tissues. Over the last decades, optimization of population Se intake for prevention of diseases related to Se deficiency or excess has been recognized as a pressing issue in modern healthcare worldwide.

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Factors Affecting Selenium Status in Infants on Parenteral Nutrition Therapy

Cited by 7 publications

References 41 publications

Selenium deficiency and supplementation in infants: a narrative review

Selenium deficiency and supplementation in infants: a narrative review

Effect of selenium‐free parenteral nutrition on serum selenium of neonates and infants maintained on long‐term parenteral nutrition

Selenium Metabolism and Biosynthesis of Selenoproteins in the Human Body

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