Factors affecting satisfaction with treatment in European women with chronic constipation: An internet survey

Emmanuel, Anton; Quigley, Eamonn Martin; Simrén, Magnus; Feng, Yong; Müller-Lissner, S; Urbain, Daniël; Tack, Jan; Bredenoord, Albert J.; Sabaté, Jean Marc; Yiannakou, Yan; Andresen, Viola; Cuomo, Rosario; Rey, Enrique; Gryp, Renate Specht; Vandeplassche, Lieve; Solomon, Dory

doi:10.1177/2050640613494200

Cited by 29 publications

(25 citation statements)

References 25 publications

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“…Paired with HRQOL data, we observed greater treatment satisfaction in patients without bloating after adjustment for other constipation‐related symptoms. Consistent with our observation, relief from bloating was the most difficult endpoint to achieve for all common therapies, in a recent European survey . A further important finding of our study was that patients with bloating were less responsive to various constipation‐related treatments independent of socio‐demographic factors, general health, therapy, and the diagnosis of IBS‐C or FC.…”

Section: Discussionsupporting

confidence: 90%

“…Consistent with our observation, relief from bloating was the most difficult endpoint to achieve for all common therapies, in a recent European survey. 19 A further important finding of our study was that patients with bloating were less responsive to various constipation-related treatments independent of sociodemographic factors, general health, therapy, and the diagnosis of IBS-C or FC. Overall, this evidence suggests that bloating might be a relevant independent target of therapy despite it currently remains without a proper clinical classification, a clear pathophysiology, and an effective treatment.…”

Section: Discussionmentioning

confidence: 54%

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Bloating is associated with worse quality of life, treatment satisfaction, and treatment responsiveness among patients with constipation‐predominant irritable bowel syndrome and functional constipation

Neri

Iovino

2016

Neurogastroenterology Motil

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Key Points• We demonstrated that patients with non-organic chronic constipation regard the symptom of bloating as a key element in assessing clinical changes and treatments' efficacy irrespective of the intensity of other symptoms• We sought to evaluate the association between bloating and quality of life, treatment satisfaction and treatment responsiveness among patients with constipation-predominant irritable bowel syndrome and functional constipation.• We enrolled 2203 patients in a two-wave cross-sectional survey: quality of life data obtained through selfadministered questionnaires were matched with reports of clinical examinations performed by gastroenterologists in 39 tertiary referral centers for the treatment of non-organic constipation.• Bloating was associated with poorer health-related quality of life and treatment satisfaction after adjustment for potential confounders and other constipation-related symptoms.• Bloating was associated with responsiveness to treatment after therapy switch independent of potential confounders. AbstractBackground The management of bloating is unclear and its relationship with patients' well-being and treatment satisfaction independent of other abdominal symptoms is uncharacterized. We evaluated the association of bloating with patient-reported outcomes. Methods Thirty-nine centers for functional gastrointestinal disorders joined the laxative inadequate relief survey. We enrolled 2203 consecutive outpatients with functional constipation (FC) or constipation-predominant irritable bowel syndrome (IBS-C) in two cross-sectional waves. Both wave 1 and 2 included the SF-12, the patient assessment of constipation-symptoms (PAC-SYM), and the treatment satisfaction questionnaire for medication (TSQM-2). Wave 2 only included a global rating of change (GRC) scale to assess patients' assessment of efficacy concerning treatment switches occurred in the 3 months prior to the interview. Bloating in the abdomen was defined on the basis of PAC-SYM item 3. Key Results The average age was 50.1 years (SD, 16.7) and 82.1% of patients were women. The prevalence of bloating was 91.6% (n = 1970). Bloating was associated with SF-12 Physical Composite Score

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 54%

Bloating is associated with worse quality of life, treatment satisfaction, and treatment responsiveness among patients with constipation‐predominant irritable bowel syndrome and functional constipation

Neri

Iovino

2016

Neurogastroenterology Motil

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“…As we wanted to include participants with self‐reported constipation rather than typical patients with chronic constipation, the Rome criteria were not used. Self‐reported chronic constipation was defined as having at least one of the following symptoms for 6 months according to the previous study: infrequent bowel movements (less than three per wk), dry stool, time‐consuming defecation, straining, a sensation of incomplete evacuation, blockage of the anus, and defecation with manual assistance.…”

Section: Methodsmentioning

confidence: 99%

Clinical features and treatment options among Chinese adults with self‐reported constipation: An internet‐based survey

Song

Bai

Zhang

et al. 2019

J of Digest Diseases

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Objective We aimed to investigate the clinical features, precipitating factors, bowel habits, bothersome symptoms and treatment strategies of individuals in China with self‐reported constipation. Methods An internet‐based survey was conducted in China. The participants had self‐reported chronic constipation (≥1 symptoms including straining, hard stools, time‐consuming defecation, sensations of incomplete evacuation and anorectal blockage, using manual assistance, and fewer than three defecations per week, for over 6 months). Data on their sex, age and occupation, precipitating factors, bowel habit, main symptoms and treatment options were collected. Results Overall, 6318 participants fulfilled the inclusion criteria for chronic constipation. More women (54.6%, n = 3450) than men reported constipation. The most common age group for constipation was 31 to 40 years (40.0%, n = 2520) and the most common occupation was office workers (43.6%, n = 2754). Disordered eating routines, consuming spicy food, and failure to defecate in time were the most common factors associated with constipation. Overall, 76.0% (n = 4804) participants did not defecate in the morning; 56.2% (n = 3548) spent 6 to 15 minutes in defecating. The most prevalent symptom was straining (39.4%, n = 2489). For preferred treatment options, 81.7% (n = 5160) selected changes in their lifestyle and diet, 51.1% (n = 3229) selected using traditional Chinese medicine, and 25.2% (n = 1590) selected using laxatives. Conclusions Constipation rates were higher in women, people aged 31 to 40 years old, and those working in offices. Having eating disorders, eating spicy food and withholding stools were the most common precipitating factors. Straining was the most prevalent symptom. Lifestyle changes were the most common action taken for managing constipation.

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“…5 Considering the quality of life and overall symptoms rather than sole alleviation of constipation should be set as the goal of current treatments. 6,7 There is not enough data whether prunes alone would have an effect on quality of life and overall symptoms, especially in constipation-associated IBS.…”

mentioning

confidence: 99%

Letter: prunes for the treatment of constipation

Pasalar

Lankarani

2014

Aliment Pharmacol Ther

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Factors affecting satisfaction with treatment in European women with chronic constipation: An internet survey

Cited by 29 publications

References 25 publications

Bloating is associated with worse quality of life, treatment satisfaction, and treatment responsiveness among patients with constipation‐predominant irritable bowel syndrome and functional constipation

Bloating is associated with worse quality of life, treatment satisfaction, and treatment responsiveness among patients with constipation‐predominant irritable bowel syndrome and functional constipation

Clinical features and treatment options among Chinese adults with self‐reported constipation: An internet‐based survey

Letter: prunes for the treatment of constipation

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