Factors affecting response to biologic treatment in psoriasis

Abstract

Psoriasis is a chronic, immune-mediated inflammatory skin disease, affecting approximately 2-4% of the population in western countries. Patients with a more severe form of the disease are typically considered for systemic therapy, including biologics. In spite of the overall superiority of biologic agents, the treatment response may differ substantially among individual patients. As with other medical conditions, a range of factors contribute to response heterogeneity observed in psoriasis. Proper identification of these factors can significantly improve the therapeutic decisions. This review focuses on potential genetic and nongenetic factors that may affect the treatment response and outcomes in patients with psoriasis.

Cardiovascular risk factors influence response to biological therapies in psoriasis

“…3,4 In the majority of reports, BMI and weight are considered the main key factors in influencing the treatment response in psoriasis, with a general trend of having a negative effect. 5 However, we did not find significant associations between BMI or weight and biological treatment response.…”

Oral mucosal lesions in psoriatic patients based on disease severity and treatment approach

“…12 Darwazeh et al 15 GT. 28 The biologicals block particular molecules such as TNF-alpha and interleukins (IL), the main causes of inflammation in psoriasis, 9,29 which may explain our finding and confirm the association between geographic tongue and psoriasis. We also observed a significantly lower prevalence of GT among smokers, which is consistent with previous studies.…”

Phosphorylation of intracellular signalling molecules in peripheral blood cells from patients with psoriasis on originator or biosimilar infliximab

“…Evaluation of immune‐mediated diseases such as psoriasis should ideally aim at the molecular aberrancy in each patient for personalized treatment . To this end, assays capable of predicting which treatments are most likely to be beneficial for each individual are required, before commencing therapy .…”