Factors Affecting Recurrence in Patients with Crohn's Disease Under Nutritional Therapy

Esaki, Motohiro; Matsumoto, Takayuki; Nakamura, Shotaro; Yada, Shinichiro; Fujisawa, Kiyoshi; Jo, Yukihiko; Iida, Mitsuo

doi:10.1007/s10350-006-0692-1

Cited by 39 publications

(33 citation statements)

References 29 publications

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“…Esaki et al [52] also noted that remission can be prolonged by supplementary enteral nutrition. They conducted a retrospective, single centre study on an adult cohort of patients with CD.…”

Section: Een and Relapsementioning

confidence: 99%

Enteral Nutrition in Crohn’s Disease: An Underused Therapy

Kansal

Wagner

Kirkwood

et al. 2013

Gastroenterology Research and Practice

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“…Esaki et al [52] also noted that remission can be prolonged by supplementary enteral nutrition. They conducted a retrospective, single centre study on an adult cohort of patients with CD.…”

Section: Een and Relapsementioning

confidence: 99%

Enteral Nutrition in Crohn’s Disease: An Underused Therapy

Kansal

Wagner

Kirkwood

et al. 2013

Gastroenterology Research and Practice

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“…A retrospective study of 145 patients in remission, with twothirds receiving maintenance EN, identified penetrating CD (RR 3.89; 95% CI 1.58-9.62), colonic involvement (RR 3.10; 95% CI 1.39-6.90) and previous history of surgery (RR 2.48; 95% CI 1.16-5.33) to be factors that predicted recurrence [Esaki et al 2006]. Recurrence rates were high (42/98 EN group versus 29/47 normal diet; p = 0.047), and it is difficult to assess the applicability of these data since remission was induced with PN and the only other therapy used was 5-aminosalicylic acid drugs.…”

Section: Maintenance Of Remission: Enteral Nutritionmentioning

confidence: 99%

Nutritional management of Crohn’s disease

Donnellan

Lee

Lal

2013

Therap Adv Gastroenterol

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Nutritional care and therapy forms an integral part of the management of patients with Crohn's disease (CD). Nutritional deficiencies result from reduced oral intake, malabsorption, medication side effects and systemic inflammation due to active disease. Enteral nutrition has a role in support for the malnourished patient, as well as in primary therapy to induce and maintain remission. The use of parenteral nutrition in CD is mainly limited to the preoperative setting or for patients with intestinal failure, but does not offer any additional advantage over EN in disease control. Dietary modifications, including eliminationreintroduction diets and a low fermentable, oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet may improve symptoms but there are currently no data to suggest that these approaches have any role in the induction or maintenance of remission.

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“…Esaki et al [31] have demonstrated in a trial of 145 patients with CD (mostly induced into remission with TPN) that, under maintenance with elemental/polymeric nutrition, the risk of recurrence was lower in those with small bowel rather than large bowel involvement.…”

Section: Enteral Feedingmentioning

confidence: 97%

Role of diet in the management of inflammatory bowel disease

Rajendran

Kumar

2010

WJG

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Many studies have looked at connections between diet, etiology, signs and symptoms associated with inflammatory bowel disease (IBD). Although these connections are apparent to clinicians, they are difficult to prove qualitatively or quantitatively. Enteral feeding and polymeric diets are equally effective at bringing about remission in Crohn's disease (CD). Parenteral feeding is also effective, although none of these methods is as effective as corticosteroid therapy. However, enteral feeding is preferred in the pediatric population because linear growth is more adequately maintained via this route. Exclusion diets in patients brought into remission using an elemental diet have been shown to maintain remission for longer periods. Studies that aim to isolate culpable food groups have shown that individuals react differently on exposure to or exclusion of various foods. The commonly identified food sensitivities are cereals, milk, eggs, vegetables and citrus fruits. Studies that have looked at gut mucosal antigen behavior have shown higher rectal blood flow, in response to specific food antigens, in those with CD over healthy subjects. Exclusion of sugar shows little evidence of amelioration in CD. Omega 3 fatty acids show promise in the treatment of IBD but await larger randomized controlled trials. Patients frequently notice that specific foods cause aggravation of their symptoms. Whilst it has been difficult to pinpoint specific foods, with advances in the laboratory tests and food supplements available, the aim is to prolong remission in these patients using dietary measures, and reduce the need for pharmacotherapy and surgical intervention.

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Factors Affecting Recurrence in Patients with Crohn's Disease Under Nutritional Therapy

Cited by 39 publications

References 29 publications

Enteral Nutrition in Crohn’s Disease: An Underused Therapy

Enteral Nutrition in Crohn’s Disease: An Underused Therapy

Nutritional management of Crohn’s disease

Role of diet in the management of inflammatory bowel disease

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