Factors affecting recurrence and progression in intravesical BCG treated high grade non muscle invasive bladder cancer

Khan, Muhammad Kashif; Ahmed, Irfan; Raza, Syed Johar

doi:10.12669/pjms.302.4117

Cited by 12 publications

(6 citation statements)

References 21 publications

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“…The five-year recurrence-free survival rate was 89% for patients with T2 tumors, 50% for patients with T4 tumors, and 35% for patients with lymph node metastasis respectively (Stein et al, 2001). Patients with NMIBCs have better prognoses, however, high grade NMIBC has a 70% recurrence rate with a 15%-40% risk of progression after five years (Kashif Khan, Ahmed & Raza, 2014).…”

Section: Introductionmentioning

confidence: 99%

Increased expression of POLR3G predicts poor prognosis in transitional cell carcinoma

Liu

Zhang

Wang

et al. 2020

PeerJ

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Background Previous studies have shown that RNA Polymerase III Subunit G (POLR3G) has oncogenic effects in cultured cells and mice. However, the role of POLR3G in transitional cell carcinoma (TCC) has not been reported. This study explores the potential of POLR3G as a novel molecular marker for TCC. Methods The RNA sequencing data and clinical information of patients with TCC were downloaded from The Cancer Genome Atlas official website. Transcriptome analysis was performed as implemented in the edgeR package to explore whether POLR3G was up-regulated in TCC tissues compared to normal bladder tissues. The expression of POLR3G in bladder cancer cell line T24 and human uroepithelial cell line SV-HUC-1 were detected via quantitative real time polymerase chain reaction (qRT-PCR). Correlations between POLR3G expression and clinicopathological characteristics were analyzed using Mann-Whitney U test or Kruskal-Wallis H test. Clinicopathological characteristics associated with overall survival were explored using the Kaplan-Meier method and Cox regression analyses. Gene set enrichment analysis (GSEA) was performed to explore the associated gene sets enriched in different POLR3G expression phenotypes and the online tool Tumor IMmune Estimation Resource (TIMER) was used to explore the correlation between POLR3G expression and tumor immune infiltration in TCC. Results Transcriptome analysis showed that POLR3G was significantly up-regulated in TCC tissues compared to normal bladder tissues. Furthermore, qRT-PCR revealed high expression of POLR3G in T24 cells compared to SV-HUC-1 cells. Overall, POLR3G expression was associated with race, tumor status, tumor subtype, T classification, and pathological stage. Kaplan-Meier survival analysis revealed that higher POLR3G expression was associated with lower overall survival. The univariate Cox regression model revealed that age at diagnosis, pathological stage, and POLR3G expression were associated with prognosis of TCC patients. Further multivariate analyses identified these three clinicopathological characteristics as independent prognostic factors for overall survival. GSEA analysis showed that several gene sets associated with tumor development and metastasis, including TGF-β signaling, PI3K-AKT-mTOR signaling, and IL6-JAK-STAT3 signaling, were significantly enriched in POLR3G high expression phenotype. Immune infiltration analysis revealed that the expression of POLR3G was significantly correlated with infiltrating levels of immune cells, including CD8+ T cells, neutrophils, and dendritic cells; and the expression of POLR3G was also significantly correlated with the expression of immune checkpoint molecules, such as PD1, PD-L1, PD-L2, CTLA4, LAG3, HAVCR2, and TIGIT. Conclusions POLR3G was up-regulated in TCC and high POLR3G expression correlated with poor prognosis. POLR3G can potentially be used as a prognostic marker for TCC and might be of great value in predicting the response to immunotherapy.

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Section: Introductionmentioning

confidence: 99%

Increased expression of POLR3G predicts poor prognosis in transitional cell carcinoma

Liu

Zhang

Wang

et al. 2020

PeerJ

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“…The meta-analysis did not, however, find an association with progression among 5 studies with 3,979 NMIBC or MIBC patients [ 6 ]. Indeed, the evidence regarding smoking and disease progression has been ambiguous [ 6 , 9 – 11 , 13 , 15 , 16 , 18 – 24 , 39 – 46 , 60 , 61 ]. The majority of studies among patients with NMIBC alone have reported no association between smoking and CSM [ 13 , 15 , 20 , 25 , 39 – 41 , 54 ] or ACM [ 11 , 25 , 26 , 39 , 40 ].…”

Section: Resultsmentioning

confidence: 99%

Lifestyle and Non-muscle Invasive Bladder Cancer Recurrence, Progression, and Mortality: Available Research and Future Directions

Zuniga

Graff

Feiger

et al. 2020

BLC

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BACKGROUND: A broad, comprehensive review of studies exploring associations between lifestyle factors and non-muscle invasive bladder cancer (NMIBC) outcomes is warranted to consolidate recommendations and identify gaps in research. OBJECTIVE: To summarize the literature on associations between lifestyle factors and clinical outcomes among patients with NMIBC. METHODS: PubMed was systematically queried for articles published through March 2019 regarding lifestyle factors and recurrence, progression, cancer-specific mortality, and all-cause mortality among patients with NMIBC. RESULTS: Notwithstanding many ambiguities, there is good-quality evidence suggesting a benefit of smoking avoidance/cessation, healthy body mass index (BMI), and type II diabetes mellitus prevention and treatment. Lactobacillus casei probiotic supplementation may reduce recurrence. There have been individual studies suggesting a benefit for uncooked broccoli and supplemental vitamin E as well as avoidance of supplemental vitamin B9, areca nut chewing, and a "Western diet" pattern high in fried foods and red meat. Additional studies do not suggest associations between NMIBC outcomes and use of fibrin clot inhibitors; insulin and other oral hypoglycemics; statins; supplemental selenium, vitamin A, vitamin C, and vitamin B6; fluid intake and intake of specific beverages (e.g., alcohol, coffee, green tea, cola); various dietary patterns (e.g., Tex-Mex, high fruit and vegetable, low-fat); and occupational and chemical exposures. CONCLUSIONS: Despite a myriad of publications on lifestyle factors and NMIBC, a need remains for research on unexplored associations (e.g., physical activity) and further studies that can elucidate causal effects. This would inform future implementation strategies for healthy lifestyle change in NMIBC patients.

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“…Настоящие результаты совпадают с данными, полученными зарубежными коллегами, например, A. Lee et al и M. Miyake et al в своих работах описали взаимосвязь размеров опухоли и времени наступления рецидива [15,22]. Аналогичные результаты были получены и другими исследователями [23][24][25][26][27][28][29].…”

Section: рис 1 патоморфологические типы (пато) мышечно-неинвазивного рака мочевого пузыряunclassified

Сlinical and histological features of non-muscle invasive bladder cancer affecting tumor recurrence

Гусниев¹,

Печникова²,

Gusniev³

et al. 2021

Clin. Exp. Morphology

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Introduction. Bladder cancer is the most common malignant neoplasm of the urinary system, which is rep-resented by non-muscle invasive bladder cancer (NMIBC), muscle invasive bladder cancer (MIBC), and metastatic tumors. NMIBCs are known to recur in 40–60% of cases and progress in 10–30% of patients. Therefore, information needs to be systematized and effective schemes for the prognosis and individual treatment for NMIBC, developed. The aim of the study was to assess the influence of clinical and histologi-cal features of the tumor on the recurrence risk in patients with NMIBC. Materials and methods. We performed a retrospective analysis of the medical histories of 100 patients with NMIBC after standard treatment. The patients were subsequently divided into two groups depending on the presence or absence of recurrent tumor. On initial and follow-up examinations, we studied sex, age, tumor size, number of lesions, degree of tumor differentiation, and the time of recurrence in the corresponding group of patients. Results. On average, the histological type of tumor with a high degree of differentiation (G1) had a smaller tumor size than histological types of tumor of moderate (G2) and low (G3) differentiation (p=0.02). Multiple bladder lesions almost twice as often resulted in recurrent neoplasms than single tumors (p=0.01). The risk of recurrence significantly reduced with increasing tumor size and decreasing degree of differentiation (p=0.5; and p=0.01 for G2 and G3, respectively). Conclusion. The research data show that clinical and histological features (histological type of tumor, the extension of the bladder lesion, and tumor size) are interrelated with recurrent bladder cancer. Keywords: non-muscle invasive bladder cancer, bladder cancer, oncology, pathology, recurrence of bladder cancer, clinical and histological features

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Factors affecting recurrence and progression in intravesical BCG treated high grade non muscle invasive bladder cancer

Cited by 12 publications

References 21 publications

Increased expression of POLR3G predicts poor prognosis in transitional cell carcinoma

Increased expression of POLR3G predicts poor prognosis in transitional cell carcinoma

Lifestyle and Non-muscle Invasive Bladder Cancer Recurrence, Progression, and Mortality: Available Research and Future Directions

Сlinical and histological features of non-muscle invasive bladder cancer affecting tumor recurrence

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