Factors affecting recurrence after surgical treatment in cases with ocular surface squamous neoplasia

Mirzayev, Ibadulla; Gündüz, Ahmet Kaan; Ateş, Funda Seher Özalp; Özcan, Gökçen; Işık, Mehmed Uğur

doi:10.18240/ijo.2019.09.09

Cited by 21 publications

(12 citation statements)

References 31 publications

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“…This is in concordance with the study which was undertaken by Li In our study limbus was involved in all cases and most of the lesion were small (5 mm in size).This is in conformity with Li et al, Meel et al which also showed the similar nding [15,33]. However, Meel et al and Mirzayev et al reported higher frequency of medium to larger tumors in their study [33,35]. The common clinical presentation in our study was papilliform mass which was similar to study conducted by Kim et al [32].…”

Section: Discussionsupporting

confidence: 92%

“…Most of the patients had already undergone excision somewhere else before reporting at our centre. The common pathological grade which was found in current study was invasive squamous cell carcinoma.This is in conformity with Mirzayev et al which also reported invasive SCC in most of the lesion( 46.4%) [35]. However, these ndings are in discordance with Li et al and Kao et al as they found more number of squamous cell carcinoma in situ during histological examination of biopsied tissues [15,36].…”

Section: Discussionsupporting

confidence: 85%

“…In a study conducted by Kirre at al, corneal scarring was found in 09 patients, symplepharon in 01 patient and allergic reaction in 01 patient [26]. Mirzayev et al reported dry eye symptoms in 14 (12.5%) patients after topical chemotherapy and mild stem cell de ciency in 5 (4.5%) cases [35]. Overall, these studies also reported minimal complication rates in their studies like our study.…”

Section: Discussionsupporting

confidence: 71%

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Clinicopathological Profile, Management and Clinical Outcomes in Recurrent Cases of Ocular Surface Squamous Neoplasia at a Tertiary Care Centre: Original Article

Kumar

Mishra

et al. 2021

Preprint

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PurposeThis study was taken up at this centre to look into the various causes of recurrence, clinicopathological profile and final outcomes in recurrent OSSN. MethodologyA prospective cohort study was conducted and total 18 patients were recruited. All patients were subjected to detailed history, comprehensive eye examination and imaging studies. A treatment plan was formulated based on the size and extent of the lesion. Primary outcome measures were resolution/regression of tumor, recurrence of the lesion and incidence of complication associated with each treatment modality.ResultsThe common cause of recurrence in our study was misdiagnosis of the lesion as in 15 cases it was diagnosed as pterygium and in 03 cases it was actinic keratosis. Excision Biopsy with adjunctive cryotherapy was the preferred treatment modality followed by topical interferon @ 2b drop in our study. We could achieve good outcomes in terms of complete regression of the tumor in 15 cases. The complication associated with this treatment was minimal in our study as few patient develop redness and irritation which got subsided after application of topical lubricants. There was no recurrence of the lesion even after 06 months of follow up in all 18 cases.ConclusionRecurrence can be mitigated in all cases of OSSN if they are diagnosed on time with institution of appropriate treatment modality. Regular follow- up is required to assess the response to treatment and change over to new treatment plan in cases with inadequate response to curb the incidence of recurrence in OSSN.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 71%

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Clinicopathological Profile, Management and Clinical Outcomes in Recurrent Cases of Ocular Surface Squamous Neoplasia at a Tertiary Care Centre: Original Article

Kumar

Mishra

et al. 2021

Preprint

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“…[23] Recurrence rates following excision of OSSN alone range from 5-69% [25][26][27][28] and after excision combined with cryotherapy range from 7.7-11.5%. [29][30] The lower rates of recurrence are seen in cases where the margins of the excised specimen were free of tumor cells and adjuvant chemotherapy has been used and the higher rates when dysplastic tissue was left at the surgical margins and in more advanced lesions. [25,26,27,28,31] Therefore, it is very important to ensure clear surgical margins.…”

Section: Resultsmentioning

confidence: 99%

Clinico-Demographic Profile and Management Outcomes of Patients With Ocular Surface Squamous Neoplasia in a Tertiary Eye Care Hospital in Nepal

Shrestha¹,

Sthapit²,

R³

2020

Preprint

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Background: To evaluate the Clinico-demographic profile and management outcomes of patients with Ocular Surface Squamous Neoplasia (OSSN) in a tertiary eye care hospital in NepalMethods: All the patients with biopsy proven OSSN presenting to Oculoplasty and Ocular Oncology department of Tilganga Institute of Ophthalmology, Nepal over 1 year were retrospectively studied for clinical and demographic profiles, medical and surgical management and the outcomes of the management. Results: A total of 39 eyes of 37 patients were included in this study. The average age of patients was 44.56 years (range- 15 years to 84 years) consisting of 21(56.8%) male and 16 (43.2%) female. The ration of participating male and female patients (M:F) was 1.31:1. 35 cases (94.6%) were unilateral whereas 2 cases with Xeroderma pigmentosa had bilateral involvement. Nasal bulbar conjunctiva in (43.58%) was the most common. 6 (16.2%), 19 (51.4%) and 12 (32.4%) patients received primary medical management alone, surgical management alone and both surgical and adjuvant medical managements respectively.Histologically, the most common finding was CIN I with 10 (31.25%) patients. Surgical margins were free in 15 eyes (46.87%), whereas 17 eyes (53.12%) had one or more margins involved and hence, they received adjuvant topical chemotherapy. Moreover, 5 (15.38%) out of 39 eyes had recurrence.Conclusion: OSSN is usually present in middle age group though it may occur early and become rapidly progressive as in the cases of Xeroderma pigmentosa. Recurrence after surgery can occur despite optimal management.

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“…The diagnosis of OST can be based on medical history and findings of specialized eye exams. (1) The most common malignant tumors of the cornea and conjunctiva are ocular surface squamous neoplasia, conjunctival melanoma and conjunctival lymphoma. (2) Several factors contribute to OST development, including exposure to ultraviolet radiation, advanced age, male gender and primary or acquired immunodeficiency.…”

Section: Introductionmentioning

confidence: 99%

Development and usability of a photograph-based smartphone app for ocular surface tumor screening

Machado¹,

Sousa²,

Araripe³

et al. 2022

Revista Brasileira De Oftalmologia

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Factors affecting recurrence after surgical treatment in cases with ocular surface squamous neoplasia

Cited by 21 publications

References 31 publications

Clinicopathological Profile, Management and Clinical Outcomes in Recurrent Cases of Ocular Surface Squamous Neoplasia at a Tertiary Care Centre: Original Article

Clinicopathological Profile, Management and Clinical Outcomes in Recurrent Cases of Ocular Surface Squamous Neoplasia at a Tertiary Care Centre: Original Article

Clinico-Demographic Profile and Management Outcomes of Patients With Ocular Surface Squamous Neoplasia in a Tertiary Eye Care Hospital in Nepal

Development and usability of a photograph-based smartphone app for ocular surface tumor screening

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