Factors Affecting Rates of Visual Field Progression in Glaucoma Patients with Optic Disc Hemorrhage

Prata, Tiago S.; Moraes, Carlos Gustavo V. De; Teng, Christopher C.; Tello, Celso; Ritch, Robert; Liebmann, Jeffrey M.

doi:10.1016/j.ophtha.2009.06.028

Cited by 82 publications

(60 citation statements)

References 44 publications

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“…This is revealing because it underlines the reduced risk of visual disability in those patients who are diagnosed in the earlier stages of the disease, not only because they have greater preserved vision to start with but they are, according to our data, less likely to progress rapidly than those patients who are diagnosed at a later stage. [27][28][29] It is worth noting that the magnitude of this effect is, however, quite small. Moreover, precision of estimates of MD rates in individual eyes varies with VF damage and this has been established elsewhere.…”

Section: Discussionmentioning

confidence: 92%

Are rates of vision loss in patients in English glaucoma clinics slowing down over time? Trends from a decade of data

Boodhna

Saunders

Crabb

2015

Eye

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Purpose To examine changes in rates of visual field (VF) progression in patients attending a sample of glaucoma clinics in England between 1999 and 2012. Methods An archive of 473 252 Humphrey VFs recorded across the UK was retrospectively examined. Distribution of rates recorded in the first half of the decade was compared with the second. The relationship between age and severity of MD loss at baseline with rates of loss and frequency of testing was examined. Results VF series from 18 926 eyes were analysed. Median rate of MD loss for the period before and after 2003 was − 0.11 and − 0.06 dB/year, respectively, but the proportion of eyes with medium or fast rates of MD loss remained constant. Median rate of MD loss in older (470 years) eyes was faster than that observed in younger (o60 years) eyes (−0.21 compared with − 0.01 dB/ year). Median rate of loss did not vary with severity of MD loss at baseline. Frequency of testing, typically carried out annually, did not vary by age, rate of loss or disease severity. Conclusions VFs of eyes treated in the first half of the decade deteriorated more rapidly than those in the second half. Several factors might explain these differences but average effects were small and there was no reduction in the proportion of rapidly progressing eyes over the decade. Older age and, to a lesser extent, worse VF damage at diagnosis are indicators for faster VF loss in clinics, but frequency of VF testing was similar for all patients.

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Section: Discussionmentioning

confidence: 92%

Are rates of vision loss in patients in English glaucoma clinics slowing down over time? Trends from a decade of data

Boodhna

Saunders

Crabb

2015

Eye

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“…Siegner and Netland 11 reported no difference in the rate of progression of optic disc shape or VF defects in eyes with recurrent DH and nonrecurrent DH. Prata et al 20 reported that DH recurrence was not a significant factor affecting the rate of VF progression in glaucoma patients with DH. Rasler et al 21 demonstrated no difference in VF progression between eyes with nonrecurrent and recurrent DH.…”

Section: Discussionmentioning

confidence: 98%

Clinical Significance of the Location of Recurrent Optic Disc Hemorrhage in Glaucoma

Kim

2015

Invest. Ophthalmol. Vis. Sci.

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PURPOSE.To compare clinical characteristics and visual field (VF) progression between glaucomatous eyes with disc hemorrhage (DH) recurring at the same or different locations in relation to the initial DH location. METHODS.One hundred forty-seven open-angle glaucoma patients with DH who were observed for more than 4 years and had more than six VF tests were included. Disc hemorrhage that recurred at the same location as the initial DH was defined as a DH at the same location, and DH that recurred at a different location was defined as a DH at a different location. Overall rate of VF change using the mean deviation (MD) was compared between groups using a linear mixed model, and Kaplan-Meier survival analysis was performed.RESULTS. Seventy-seven (52.4%) eyes had nonrecurrent DH, and 70 (47.6%) eyes had recurrent DH detected during the follow-up period. Recurrent DH at the same location (À0.32 dB/y) was not significantly different from the nonrecurrent DH group in terms of the rate of VF change (P ¼ 0.116). However, the recurrent DH group at different locations (À1.07 dB/y) had a significantly different rate of VF change compared to the recurrent DH group at the same location (P ¼ 0.014). By Kaplan-Meier analysis, eyes with recurrent DH at different locations showed the fastest time to VF progression compared to other groups (log rank test, P < 0.001).CONCLUSIONS. Eyes with recurrent DH recurring at different locations from initial DH sites had more pronounced VF progression.

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“…These reports suggest that POAG including NTG is associated with alterations in factors related to ocular blood flow. There is also sufficient evidence that optic disc hemorrhage is an important risk factor for glaucoma progression (Daugeliene et al, 1999;Leske et al, 2003;Bengtsson et al, 2008;Prata et al, 2010). Additionally, increasing peripapillary atrophy, which might be related with hypoperfusion to the ONH, was reportedly associated with progressive glaucoma (Araie et al, 1994;Uchida et al, 1998;Daugeliene et al, 1999), and it has been reported that non-use of calcium channel blockers was significantly associated with the progression of visual field loss in NTG (Daugeliene et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Optic Nerve Head Blood Flow in Glaucoma

Sugiyama¹,

Shibata²,

Kojima³

et al. 2011

The Mystery of Glaucoma

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Factors Affecting Rates of Visual Field Progression in Glaucoma Patients with Optic Disc Hemorrhage

Cited by 82 publications

References 44 publications

Are rates of vision loss in patients in English glaucoma clinics slowing down over time? Trends from a decade of data

Are rates of vision loss in patients in English glaucoma clinics slowing down over time? Trends from a decade of data

Clinical Significance of the Location of Recurrent Optic Disc Hemorrhage in Glaucoma

Optic Nerve Head Blood Flow in Glaucoma

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