Factors affecting mixed-mode retention properties of cation-exchange stationary phases

A C4-modified bipyridinium multi-mode stationary phase for reversed phase, hydrophilic interaction and ion exchange chromatography

“…23–26 The multi-mode chromatography stationary phase has been well researched and developed as a hot spot in stationary phase research. 27,28 Yang et al used propylamine on silicon as the starting material, and then carried out an amine–epoxy reaction with 1,4-butaneglycol diglycerol and tertiary amine ( N , N -dimethyldecylamine, DMDA) to prepare a RPLC/HILIC/IEC multi-mode stationary phase, it was found to have good compatibility with a 100% water mobile phase and could effectively separate several compounds or drug molecules and their counter ions in a single run. 30…”