Factors Affecting Mixed-Mode Retention Properties of Cation-Exchange Stationary Phases

A C4-modified bipyridinium multi-mode stationary phase for reversed phase, hydrophilic interaction and ion exchange chromatography

“…[23][24][25][26] The multi-mode chromatography stationary phase has been well researched and developed as a hot spot in stationary phase research. 27,28 Yang et al used propylamine on silicon as the starting material, and then carried out an amine-epoxy reaction with 1,4-butaneglycol diglycerol and tertiary amine (N,N-dimethyldecylamine, DMDA) to prepare a RPLC/HILIC/IEC multi-mode stationary phase, it was found to have good compatibility with a 100% water mobile phase and could effectively separate several compounds or drug molecules and their counter ions in a single run. 30 Ionic liquids (ILs) are a class of non-molecular substances with extremely low vapor pressure and volatility, high solubility, high thermal stability, an adjustable structure and solubility, good electrical conductivity and so on.…”