Factors Affecting Late Mortality From Heart Disease After Treatment of Hodgkin's Disease

Hancock, Steven; Tucker, Margaret A.; Hoppe, Richard T.

doi:10.1001/jama.1993.03510160067031

Cited by 639 publications

(261 citation statements)

References 37 publications

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“…The leading cause of non-cancer mortality among long-term survivors after radiotherapy for Hodgkin's lymphoma was cardiovascular death [10]. It should be noted that radiation doses applied to the whole heart have been much higher than in the treatment of breast cancer, even in those times [11,12,13]. In Scandinavian breast cancer studies, mainly an increased incidence of ischemic events and unclear cardiac deaths was observed [2,6].…”

Section: Cardiotoxicity Of Radiotherapymentioning

confidence: 99%

Cardiac Toxicity after Radiotherapy for Breast Cancer: Myths and Facts

et al. 2015

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Section: Cardiotoxicity Of Radiotherapymentioning

confidence: 99%

Cardiac Toxicity after Radiotherapy for Breast Cancer: Myths and Facts

et al. 2015

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“…Second malignant neoplasms, especially ALL, are also among the late effects of therapy [33,34,[37][38][39] . Antineoplastic drugs, especially anthracyclines and mediastinal radiotherapy can cause decrease in cardiac contractility, heart insufficiency, pericardial effusion, constrictive pericarditis, coronary artery disease, myocardial infarction, and arrhythmias [15][16][17][18][19]40] . Vascular narrowing and cerebrovascular accidents are also among the late complications.…”

Section: Treatment Toxicity In Hlmentioning

confidence: 99%

“…Therefore, screening of cardiac functions of these individuals after ceseation of cancer treatment is particularly important and the principles for the following-up of these patients have been published [14] . Some researchers have reported higher relative risks of myocardial infarction mortality in patients treated at younger ages than in patients treated at older ages and in men than in women [15][16][17][18][19] . Other researchers have reported valvular dysfunction, carotid, subclavian and coronary artery disease and even fatality from cardiac infarction at early childhood after radiation therapy for the treatment of Hodgkin lymphoma (HL) [20][21][22][23] .…”

Section: Introductionmentioning

confidence: 99%

Risks and diagnosis of coronary artery disease in Hodgkin lymphoma survivors

Küpeli

2014

WJC

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Higher mortality rates are reported because of cardiovascular diseases in individuals living in industrialized areas of the World. In cancer patients, cardiotoxic chemotherapeutic agents and/or mediastinal radiotherapy are additional risk factors for the development of coronary artery disease. An improved survival rate for patients with Hodgkin lymphoma was reported in recent decades. Determining and handling the long-term effects of cancer treatment have become more important nowadays, parallel to the good results reached in survival rates. Mediastinal radiotherapy and cardiotoxic chemotherapeutic agents are routinely used to treat Hodgkin lymphoma but are commonly associated with a variety of cardiovascular complications. Drugs used in cancer treatment and radiotherapy may cause deleterious effects on contractile capacity and conduction system of the heart. Approximately ten years after the completion of all therapies, the cardiovascular disease risk peaks in patients who survived from Hodgkin lymphoma. The value of coronary computed tomography angiography as a diagnostic tool in determining coronary artery disease as early as possible is underlined in this review, in patients who are in remission and carry the risk of coronary artery disease probably because of chemo/radiotherapy used in their treatment. Survivors of Hodgkin lymphoma especially treated with combined chemoradiotherapy at younger ages are candidates for coronary computed tomography angiography.

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“…However, radiation-induced CAD has decreased substantially with the advent of current radiation protocols [23]. Fatal myocardial infarction often occurs without prior angina or CHF symptoms [24]. Supraventricular tachyarrhythmias, i.e., atrial fibrillation and atrial flutter, are commonly observed in cancer patients under chemotherapeutic regimens, the pathogenesis of which is incompletely understood [25].…”

Section: Effects Of Oncological Treatment On the Pathogenesis Of Cardmentioning

confidence: 99%

Treatment of cardiovascular diseases in cancer patients

Noutsias

Maisch

2011

Herz

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Cardiovascular diseases and cancer are the leading causes of death in the Western world. Cancer treatment has been associated with cardiovascular complications, among others cardiotoxicity of mediastinal radiation and certain chemotherapeutics. Identification of patients at high risk, prevention, early diagnosis, and treatment of cardiovascular diseases are emerging fields in cancer patients. Close interdisciplinary work between oncologists and cardiologists is pertinent for the treatment of cardiovascular diseases and complications in cancer patients. Diagnostics and treatment applied to the individual case should be based on the available evidence in terms of patient-centered management. Further clinical research focused on the pathogenesis and treatment of cardiovascular diseases in cancer patients is warranted to pave the way to guidelines for this nonhomogeneous patient group.

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Factors Affecting Late Mortality From Heart Disease After Treatment of Hodgkin's Disease

Cited by 639 publications

References 37 publications

Cardiac Toxicity after Radiotherapy for Breast Cancer: Myths and Facts

Cardiac Toxicity after Radiotherapy for Breast Cancer: Myths and Facts

Risks and diagnosis of coronary artery disease in Hodgkin lymphoma survivors

Treatment of cardiovascular diseases in cancer patients

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