“…Prevention of LO has been studied over the years and the exact etiology remains elusive but has been associated with trauma during extraction, local anesthetics with vasoconstrictors, oral contraceptive use, gender, patient age, tooth location, smoking, physical dislodgement of the clot, bacterial infection, eruption pattern timing of tooth removal, and operator skill [2, 7, 8]. Preventative treatments have ranged from altered surgical technique, systemic antibiotic use, antimicrobial rinses, socket lavage, to medicaments placed within the socket at the time of surgery (Gelfoam saturated with Cleocin, Gelfoam with Tetracycline, Tetracycline alone, Terra-Cortril on Gelfoam, Chlorhexidine rinses or gel, thorough saline irrigation, use of calcium sulfate and use of activated platelet rich plasma) [2, 7, 9–13]. The application of PRF use within oral and maxillofacial surgery was first described by Dr. Joseph Choukroun, who used a centrifuge to develop a platelet-rich fibrin clot from autogenous whole blood [14].…”