Factors affecting inappropriate prescription of antibiotics and the emergence of antibiotic resistance in patients in primary health care

Raspopovic, Katarina; Janković, Slobodan; Opančina, Valentina

doi:10.5937/mckg50-12699

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…The drug resistant pathogens have high virulence rate which elevate the mortality and morbidity rates [3]. One of the favorable habitats for drug resistant pathogens to explore is human body and hospitals which are often unrecognized [4]. In most of the cases, the normal flora is being treatment without diagnosing the real causative agents.…”

Section: Introductionmentioning

confidence: 99%

Phytogenic synthesis of silver nanobactericides for anti-biofilm activity against human pathogen H. pylori

et al. 2019

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The present study reports the phytogenic synthesis of silver nanobactericides using Acorus calamus L. and their antibiofilm activity against clinically isolated H. pylori. The synthesis was confirmed with change in the color of the reaction mixture to brown. The increased in the color intensity was periodically monitored with UV-visible spectroscopy which displayed maximum absorption at 410 nm. The biomolecular interaction was studied with FTIR spectral measurements of silver nanobactericides which revealed the presence of broad absorbance band appearing at 3361 is due to OH group and the prominent peak at 1634 correspond to an amide group. X-ray diffraction (XRD) displayed Bragg's intensities at 2θ angle reflecting (111), (200), (220) and (311) of the face centered cubic (fcc) structure of silver which was compared with standard XRD pattern. The morphological characteristics of nanobactericides were studied using Transmission electron microscopy (TEM) analysis which revealed the polydispersity of nanoparticles with size ranging from 5 to 60 nm. The anti-biofilm activity of silver nanobactericides against H. pylori was measured using crystal violet and ruthenium red assays which revealed 350 µg/mL to be more effective. The obtained activity was validated with standard antibiotics amoxicillin. Overall, the results obtained in the present investigation are promising enough to reveal the efficacy of silver nanoparticles to inhibit the biofilm production.

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Section: Introductionmentioning

confidence: 99%

Phytogenic synthesis of silver nanobactericides for anti-biofilm activity against human pathogen H. pylori

et al. 2019

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Uncovering influential factors in human antibiotic prescribing: a meta-synthesis study informed by the Theoretical Domains Framework

Acampora,

Paleologo,

Graffigna

et al. 2024

Journal of Hospital Infection

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Complex Determinants Influencing Inappropriate Antibiotic Use - A Systematic Review

Aithal

Pradhan

Aithal³

et al. 2020

IJHSP

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Antibiotic medicine is a kind of antimicrobial substance used to fight against the bacteria entered to the human body and hence is considered as a most important category of antibacterial agents to fight against bacterial infections either by killing them or inhibiting their growth. Antibiotic medications are widely used both for preventing and curing infections in human beings, animals, and agricultural plants but are not effective against viral infections, such as the common cold, flu, coughs, sore throats, etc. Even though antibiotics found their importance in fighting against bacterial infections, inappropriate use of them in humans, animals, and agricultural plants has considered as one of the reasons for developing antimicrobial resistance in them and which has several negative effects from different stakeholders’ points of view. In this paper, through a systematic review, we made an attempt to study the determinant issues and complex affecting factors which influence the inappropriate antibiotic use and its consequences in controlling bacterial infections. The study focus on identifying and analyzing misuse of antibiotics including challenges involved in the inappropriate use of Antibiotics, the determinant factors influencing the inappropriate use of antibiotics through a systematic review, predict the determinant factors affecting the process of inappropriate use of antibiotics in an ideal situation which is the final goal of antibiotics research, developing a model by identifying the determinant factors which affects the decision of inappropriate use of antibiotics in society by various stakeholders. It also includes identifying the research gap which is the difference between current status and future anticipated optimistic ideal state and to develop research agendas based on identified research gap on inappropriate use of antibiotics and its effect on human health. Keywords: Antibiotics, Inappropriate use, Humans and agriculture, Research agenda, Research gap, Antimicrobial resistance.

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Factors affecting inappropriate prescription of antibiotics and the emergence of antibiotic resistance in patients in primary health care

Cited by 3 publications

References 21 publications

Phytogenic synthesis of silver nanobactericides for anti-biofilm activity against human pathogen H. pylori

Phytogenic synthesis of silver nanobactericides for anti-biofilm activity against human pathogen H. pylori

Uncovering influential factors in human antibiotic prescribing: a meta-synthesis study informed by the Theoretical Domains Framework

Complex Determinants Influencing Inappropriate Antibiotic Use - A Systematic Review

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