Factors affecting endometrial and subendometrial blood flow measured by three-dimensional power Doppler ultrasound during IVF treatment

Ng, Ernest Hung Yu; Chan, Chung-hong; Tang, Oi Shan; Yeung, William Shu Biu; Ho, Pak Chung

doi:10.1093/humrep/dei442

Cited by 56 publications

(21 citation statements)

References 36 publications

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“…One study showed that neither age nor type of infertility affected endometrial or subendometrial blood flow [22]. However, other studies have shown that the FI is significantly lower among women older than 31 but significantly higher in mothers.…”

Section: Discussionmentioning

confidence: 99%

The effect of fertility stress on endometrial and subendometrial blood flow among infertile women

Yan

Cai

Xing

et al. 2017

Reprod Biol Endocrinol

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BackgroundTo investigate the effect of fertility stress on endometrial and subendometrial blood flow among infertile women.MethodsThis case–control study was conducted in The First Affiliated Hospital of Zhengzhou University. The fertility problem inventory (FPI) was adopted to evaluate fertility stress. Three-dimensional power Doppler ultrasonography (3D PD-US) was performed during the proliferative phase of the menstrual cycle (days 5–11) to measure endometrial thickness, pattern, endometrial and subendometrial volume (V), the vascularization index (VI), the flow index (FI) and the vascularization-FI (VFI) index. Then, 300 infertile women were separated into two groups (high-score group and low-score group) based on total FPI scores and 80 healthy women were selected as controls.ResultsNo differences were found among all three groups with regard to general characteristics, endometrial thickness, pattern, endometrial and subendometrial V, VI and VFI. The endometrial and subendometrial FIs associated with different stress levels significantly differed among the three groups (F = 33.95, P < 0.001; F = 44.79, P < 0.001, respectively). The endometrial and subendometrial FIs in the control group were significantly higher than those in the high-score group and low-score groups. The endometrial and subendometrial FIs in the low-score group were significantly higher than those in the high-score group. The total FPI score was closely related to the endometrial and subendometrial FIs (r = −0.304, P < 0.001; r = −0.407, P < 0.001, respectively).ConclusionFertility stress was associated with endometrial and subendometrial flow index. Whether fertility stress might affect pregnancy outcome by reducing endometrial and subendometrial blood flow requires further research.

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Section: Discussionmentioning

confidence: 99%

The effect of fertility stress on endometrial and subendometrial blood flow among infertile women

Yan

Cai

Xing

et al. 2017

Reprod Biol Endocrinol

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“…97 It has also been reported that endometrial and subendometrial blood flows are negatively affected by serum estradiol concentrations, but they are not affected by other factors, such as women age, smoking habits, or types of infertility or parity, during IVF treatment. 98 This fact could explain that ovarian hyper-responders tend to have lower endometrial and subendometrial blood flows during the early luteal phase (+2 hCG day). 99 We have observed that endometrial FI is significantly decreased after pituitary suppression with a long GnRH protocol.…”

Section: Dsjuogmentioning

confidence: 99%

Ultrasound Markers of Implantation

Mercé¹,

Barco²

2012

Donald School Journal of Ultrasound in Obstetrics and Gynecology

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Endometrial 3D power Doppler indices change significantly during the normal menstrual cycle. Vascularity indices of the endometrial and subendometrial vessels increase throughout the proliferative phase of the menstrual cycle, reaching a maximum value 2 to 3 days prior to ovulation. From this peak, vascularity indices decrease and reach a nadir 2 to 5 days after ovulation. Reduced endometrial perfusion assessed by 3D power Doppler ultrasound is most likely related to increased uterine contractility. If prolonged, it may cause endometrial hypoxia, leading to detrimental effect on implantation potential. In normal spontaneous menstrual cycles, endometrial vascular indices increase progressively during the course of the luteal phase. Endometrial and subendometrial perfusion is negatively affected by serum estradiol concentrations, which can explain why patients with hyperstimulation have lower endometrial and subendometrial blood flow during the early luteal phase. Our results indicate that 3D power Doppler implantation markers are crucial for planning a single embryo transfer in order to select the most suitable cycle for transfer of a single cryopreserved embryo.

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“…De telles anomalies expliquent la survenue de ménométrorragies en l'absence de lésion intracavitaire, en particulier dans le cas des myomes interstitiels et sous-séreux ne déformant pas la cavité. Les données de l'échographie-doppler retrouvent également une modification de la vascularisation utérine en cas de présence du myome au profit du myome et au détriment de l'endomètre adjacent [17,18].…”

Section: Anomalies De La Vascularisation De L'utérusunclassified

Place des myomectomies en situation de conception spontanée ou chez la femme désireuse de préserver sa fertilité

Legendre

Brun

Fernandez

2011

Journal de Gynécologie Obstétrique et Biologie de la Reproducti

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Factors affecting endometrial and subendometrial blood flow measured by three-dimensional power Doppler ultrasound during IVF treatment

Abstract: Endometrial blood flow in IVF treatment was negatively affected by serum E2 concentration only.

Cited by 56 publications

References 36 publications

The effect of fertility stress on endometrial and subendometrial blood flow among infertile women

The effect of fertility stress on endometrial and subendometrial blood flow among infertile women

Ultrasound Markers of Implantation

Place des myomectomies en situation de conception spontanée ou chez la femme désireuse de préserver sa fertilité

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