Factors affecting calcium phosphate mineralization within bulk alginate hydrogels

Strasser, Vida; Matijaković, Nives; Josipović, Tea Mihelj; Kontrec, Jasminka; Lyons, Daniel Mark; Kralj, Damir; Sikirić, Maja Dutour

doi:10.1007/s10965-019-1942-y

Cited by 7 publications

(4 citation statements)

References 65 publications

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“…By immersing the prepared hydrogel in a CaCl 2 /NaH 2 PO 4 solution, calcium phosphate (CaP) nanoparticles can be grown in situ in the gel network [ 47 ]. This solution not only improves the mechanical properties of the hydrogel, but also effectively enhances its osseointegration and osteoconductivity [ 48 ].…”

Section: Resultsmentioning

confidence: 99%

Applications of Hydrogel with Special Physical Properties in Bone and Cartilage Regeneration

Lin

Yin

et al. 2021

Materials

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Hydrogel is a polymer matrix containing a large amount of water. It is similar to extracellular matrix components. It comes into contact with blood, body fluids, and human tissues without affecting the metabolism of organisms. It can be applied to bone and cartilage tissues. This article introduces the high-strength polymer hydrogel and its modification methods to adapt to the field of bone and cartilage tissue engineering. From the perspective of the mechanical properties of hydrogels, the mechanical strength of hydrogels has experienced from the weak-strength traditional hydrogels to the high-strength hydrogels, then the injectable hydrogels were invented and realized the purpose of good fluidity before the use of hydrogels and high strength in the later period. In addition, specific methods to give special physical properties to the hydrogel used in the field of bone and cartilage tissue engineering will also be discussed, such as 3D printing, integrated repair of bone and cartilage tissue, bone vascularization, and osteogenesis hydrogels that regulate cell growth, antibacterial properties, and repeatable viscosity in humid environments. Finally, we explain the main reasons and contradictions in current applications, look forward to the research prospects in the field of bone and cartilage tissue engineering, and emphasize the importance of conducting research in this field to promote medical progress.

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Section: Resultsmentioning

confidence: 99%

Applications of Hydrogel with Special Physical Properties in Bone and Cartilage Regeneration

Lin

Yin

et al. 2021

Materials

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“…Currently, several recent studies show interesting results with hydrogels only as bone cements. However, exclusive hydrogel use for biomedical purposes leads to technological limitations as media and pH have a great influence on the gelling and stability of hydrogels [ 29 ]. Alginate–ceramic composite hydrogels are an interesting prospect as a delivery system [ 27 ] but for the lytic activity to endure over time, another approach with solid material structures should be adopted.…”

Section: Discussionmentioning

confidence: 99%

A Localized Phage-Based Antimicrobial System: Effect of Alginate on Phage Desorption from β-TCP Ceramic Bone Substitutes

et al. 2020

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Tricalcium phosphate (TCP) is a prosthetic material commonly used as a bone substitute to repair osteoarticular diseases and injuries. In this type of bone reconstruction surgery, antibiotics remain the common preventive and therapeutic treatment for bacterial infection. Nevertheless, the emergence of multi-resistant strains requires complimentary or alternative treatments. Today, one of the promising alternative approaches is phage therapy. Phages are bacterial viruses that have several advantages over chemotherapy, such as the specificity of bacterial strain, the absence of side effects, and a rapid response. In this work, we studied the impact of alginate hydrogels for overlaying λvir-phage-loaded β-TCP ceramic bone substitutes, delaying the phage desorption. The results show that the use of a 1% alginate–CaCl2 hydrogel overlapping the β-TCP ceramic pellets leads to higher initial phage concentration on the material and extends the released time of phages to two weeks when compared with control pellets. These alginate-coated biomaterials also generate faster bacterial lysis kinetics and could therefore be a good practical prosthetic device for bone and joint surgeries by allowing local treatment of bacterial infections with phage therapy for a longer period of time.

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“…Its G blocks concentrated Ca ions, promoting hydroxyapatite mineralization [ 64 , 119 ]. In vitro experiments, spherical ACP can be rapidly formed in alginate hydrogel, with ACP quickly transforming into OCP, a precursor to HAP crystal, under physiological PH [ 120 ]. The advantage of alginate hydrogels for enamel remineralization is that they can regulate the mineralization rate [ 120 ].…”

Section: Applications Of Hydrogels In Enamel Remineralizationmentioning

confidence: 99%

“…In vitro experiments, spherical ACP can be rapidly formed in alginate hydrogel, with ACP quickly transforming into OCP, a precursor to HAP crystal, under physiological PH [ 120 ]. The advantage of alginate hydrogels for enamel remineralization is that they can regulate the mineralization rate [ 120 ]. In sodium alginate hydrogels formed by cation cross-linking, the application of Ca 2+ as a cross-linking agent promotes mineralization, whereas the addition of Barium ion (Ba 2+ ), which does not easily interact with PO 4 3− groups, antagonizes this phenomenon.…”

Section: Applications Of Hydrogels In Enamel Remineralizationmentioning

confidence: 99%

The application of hydrogels for enamel remineralization

Liao,

Qiu,

Lin

et al. 2024

Heliyon

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Factors affecting calcium phosphate mineralization within bulk alginate hydrogels

Cited by 7 publications

References 65 publications

Applications of Hydrogel with Special Physical Properties in Bone and Cartilage Regeneration

Applications of Hydrogel with Special Physical Properties in Bone and Cartilage Regeneration

A Localized Phage-Based Antimicrobial System: Effect of Alginate on Phage Desorption from β-TCP Ceramic Bone Substitutes

The application of hydrogels for enamel remineralization

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