Factors affecting bone mineral density in postmenopausal women

Heidari, Behzad; Hosseini, Seyed Reza; Javadian, Yahya; Bijani, Ali; Sateri, Mohammad Hassan; Nouroddini, Haj Ghorban

doi:10.1007/s11657-015-0217-4

Cited by 67 publications

(58 citation statements)

References 28 publications

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“…The elderly presented high proportions of chronic diseases, which are usually diagnosed before the age of 60. There is other evidence that the presence of chronic diseases such as diabetes, hypertension and dyslipidemia [9], obesity and metabolic syndrome [10] were not associated with low BMD in post-menopause women, but the study presented herein is the first to carry out such evaluation for elderly men.…”

Section: Discussionmentioning

confidence: 80%

“…Deficiency in estrogen levels results in lower bone metabolic activity, increasing bone reabsorption and consequently progressive loss of trabecular bone [10,20].…”

Section: Discussionmentioning

confidence: 99%

“…Another question that must be considered regarding the association between BMD and frailty is the BMI adjustment, as it can act as a modifier in the association [10,32] and therefore BMI must be always considered in multivariate analyses.…”

Section: Discussionmentioning

confidence: 99%

“…Within the last years, the frailty syndrome has been increasingly highlighted due to its complex nature [7], with high prevalence and mortality [8], and its relationship with different health conditions has been investigated [9,10]. The majority of studies has analyzed frailty as a predictor of low BMD and indicate a causal relationship with low BMD [2,3,11].…”

Section: Introductionmentioning

confidence: 99%

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Association of Bone Mineral Density with Frailty, Pre-Frailty, and Osteoporosis in Community-Dwelling Elderly: A Prospective Study

Araujo¹

2017

J Geriatr Med Gerontol

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Objectives: To examine the association of Bone Mineral Density (BMD) in the prediction of frailty, pre-frailty, osteoporosis, falls and health conditions in elderly men and women. Methods:A four-year prospective study (2009)(2010)(2011)(2012)(2013) with 106 elderly, both sexes, aged ≥ 60 years, of the city of Goiânia, Brazil. BMD was estimated using dual-energy X ray absorptiometry. Frailty was assessed subjectively, including the following components: unintentional weight loss, fatigue, and low physical activity, reduction of strength and gait speed. Results:Mean age was 70 years of age and Body Mass Index (BMI) was 26.7 kg/m 2 . The mean BMD for women was 1.042 (± 0.11) g/cm 2 while for men, mean BMD was 1.169 (± 0.12) g/cm 2 , (p = 0.000). After adjustments for age and BMI in women, lower BMD values were significantly associated with osteoporosis (p = 0.003), frailty (p = 0.033), and pre-frailty (p = 0.037).Conclusion: BMD was predictive of frailty, pre-frailty and osteoporosis in women. In men, no associations were established. KeywordsBone mineral density, Frailty, Osteoporosis, Muscle strength, Elderly creases in Bone Mineral Density (BMD) are due to the natural ageing process for both sexes, however more prevalent for women [3][4][5][6], with consequences such as increased risk of fractures [3,6], falls and incapacities in the female group [2].Within the last years, the frailty syndrome has been increasingly highlighted due to its complex nature [7], with high prevalence and mortality [8], and its relationship with different health conditions has been investigated [9,10]. The majority of studies has analyzed frailty as a predictor of low BMD and indicate a causal relationship with low BMD [2,3,11]. However, analysis of BMD as a predictor of frailty has not been extensively investigated [12,13]; existing research has presented controversial results. While research finds no association between frailty and BMD in older women, another study observed associations between low BMD and frailty markers such as: low strength and low gait speed in men [12,13].A plausible explanation for the relationship between frailty and low bone mineral density is that the parameters used as frailty markers in the elderly such as advanced age, weight loss, low body weight, sarcopenia, the low level of physical exercise, and impaired mobility, since mechanical crucial is loading to bone mass maintenance [14]. The research presented herein considers the current context of population ageing, as well as the importance of BMD in the general and bone health of elderly. The results presented herein can add relevant RESEARCH ARTICLE

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Section: Discussionmentioning

confidence: 80%

“…Deficiency in estrogen levels results in lower bone metabolic activity, increasing bone reabsorption and consequently progressive loss of trabecular bone [10,20].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association of Bone Mineral Density with Frailty, Pre-Frailty, and Osteoporosis in Community-Dwelling Elderly: A Prospective Study

Araujo¹

2017

J Geriatr Med Gerontol

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“…In this study, a negligible correlation was determined between BMI and BMD values for femoral neck region, but no statistically significant correlation was observed for lumbar region. In a cross-sectional case-control study including 537 postmenopausal women, it was shown that BMI correlated positively with femoral neck and lumbar spine BMD (15). In the community-based study analysis [National Health and Nutrition Examination Survey (NHANES III) in which 2.590 women and 2.391 men between 50-79 years of age were included, the most important and statistically significant risk factors identified were low BMI, low calcium intake, current cigarette smoking, and physical inactivity (16).…”

Section: Discussionmentioning

confidence: 99%

The Relationship of Osteoporosis Risk Factors with Bone Mineral Density in Patients Admitted Our Outpatient Clinic in Trabzon

Beyazal¹,

Çapkın²,

Karkucak³

et al. 2016

Tod

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Amaç: Bu çalışmada amacımız Trabzon ilinde ayakta tedavi kliniğine başvuran hastalarda osteoporoz (OP) risk faktörlerinin kemik mineral yoğunluğu (KMY) ile ilişkisini belirlemektir. Gereç ve Yöntem: Çalışmaya OP veya osteopeni tanılı 201 hasta dahil edildi. Hastaların sosyodemografik özellikleri kaydedildi ve standardize araştırma formu araştırmacı hekim tarafından dolduruldu. KMY ölçümleri dual enerji X-ray taraması ile lomber omurga ve femur boynundan yapıldı. Bulgular: Hastaların yaş ortalaması 61,47±10,57 yıl (182 kadın/19 erkek) idi. Yüz on beş hasta (%57,2) osteoporotik, 86 hasta (%42) osteopenikti. Yaş ile femoral T skorları arasında negatif yönde anlamlı korelasyon bulundu. Gebelik sayısı lomber T skorları ile negatif yönde anlamlı korelasyon gösterdi. Vücut kitle indeksi ve günlük çay tüketimi ile femoral T skorları arasında ihmal edilebilir pozitif yönde korelasyon tespit edildi. Menarş yaşı, menopoz yaşı, toplam laktasyon süresi, ve günlük kalsiyum tüketimi ile KMY arasında herhangi bir korelasyon bulunmadı. Sonuç: OP için yöresel risk faktörlerinin tanımlanması klinik uygulamalarda hastaların OP risk yönetimine faydalı olabilir. Anahtar kelimeler: Osteoporoz, risk faktörleri, kemik mineral yoğunluğu Objective: Our aim was to identify the relationship of osteoporosis (OP) risk factors with bone mineral density (BMD) in patients admitted our outpatient clinic in Trabzon. Materials and Methods: Two hundred one patients with OP or osteopenia were included in this study. Sociodemographic characteristics of the patients were recorded and a standardized interview was employed by the researcher physician. BMD values were measured by dual energy X-ray absorptiometry at lumbar spine and femoral neck. Results: The mean age of the patients was 61.47±10.57 years (182 females/19 males). One hundred fifteen patients (57.2%) were osteoporotic and 86 (42.8%) were osteopenic. A significant negative correlation was found between age and femoral neck T scores. The number of pregnancies showed a significant negative correlation with lumbar T scores. Body mass index and daily tea consumption showed a negligible positive correlation with femoral neck T scores. No association was found between age at menarche, age at menopause, total lactation duration, daily calcium intake and T scores of lumbar spine and femoral neck. Conclusions: Identification of regional OP risk factors may be useful for the OP risk management of patients in clinical practice.

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Pathways linking activity, adiposity, and inflammation to bone mineral density in women and men from NHANES 2007 to 2010

Griffin

Dent

Berger

2021

American J Hum Biol

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Objectives Age, sedentary activity, central adiposity, and inflammation have all been independently associated with bone mineral density (BMD). We assessed how the effects of sedentary activity and central adiposity on BMD of the lumbar spine and femoral neck change across early to late adulthood and whether these relationships are mediated by inflammation. Methods We analyzed data from 7135 women and men 20 years of age and older from NHANES 2007 to 2010. Anthropometrics, sedentary activity (min/day), serum CRP (mg/dl), and BMD (gm/cm2 measured by DXA scans) at the femoral neck and lumbar spine. Data were compared by age and sex groups and through causal mediation analysis. Results The effect of waist circumference on BMD was significantly mediated by serum CRP at both skeletal sites in men and at the femoral neck in women. Sedentary activity did not have a direct relationship to BMD but was mediated by waist circumference in men. Least square means differed significantly by sex and age groups with a general age‐related decline in BMD at both skeletal sites. Conclusions We found that central adiposity, independent of overall body size and composition as measured through BMI, has an inverse relationship with BMD that is mediated by serum CRP. In addition, the negative impact of increased sedentism acted through changes in central adiposity (waist circumference) but only in men. Although low bone density and osteoporosis are often considered degenerative diseases that primarily impact postmenopausal women, our findings show that sedentary activity and central adiposity impact bone density beginning in early adulthood in both women and men.

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Factors affecting bone mineral density in postmenopausal women

Abstract: The results of this study indicated a significant association between OP and MD, obesity, parity, MS, history of fracture, serum ferritin, level of education, and physical activity. However, the direction and the strength of association varied across BMD measurement sites.

Cited by 67 publications

References 28 publications

Association of Bone Mineral Density with Frailty, Pre-Frailty, and Osteoporosis in Community-Dwelling Elderly: A Prospective Study

Association of Bone Mineral Density with Frailty, Pre-Frailty, and Osteoporosis in Community-Dwelling Elderly: A Prospective Study

The Relationship of Osteoporosis Risk Factors with Bone Mineral Density in Patients Admitted Our Outpatient Clinic in Trabzon

Pathways linking activity, adiposity, and inflammation to bone mineral density in women and men from NHANES 2007 to 2010

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