Factors affecting blood levels of vitamin A

Gamble, Mary V.; Blaner, William S.

doi:10.1007/978-3-0348-8454-9_1

Cited by 6 publications

(12 citation statements)

References 103 publications

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“…This finding is in accordance with previous reports 15,16 . Serum retinol levels are under homeostatic control, most probably mediated by the concentration of retinol binding protein 25 . Retinyl palmitate is the storage form of retinol.…”

Section: Discussionsupporting

confidence: 93%

“…The serum and lung tissue levels of retinol did not correlate 16 . Normal serum levels of retinol A therefore do not necessarily reflect normal lung tissue levels 25,26 . No correlation was observed between age and retinoid levels.…”

Section: Discussionmentioning

confidence: 84%

“…It is not clear if other tissues contribute to the circulating levels of retinoic acid. In the human circulation both the all‐ trans ‐ and 13‐ cis ‐retinoic acid isomers are normally present 25 . There is an established connection between the expression of specific retinoid receptors and lung cancer 2 .…”

Section: Discussionmentioning

confidence: 99%

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Serum retinoic acid, retinol and retinyl palmitate levels in patients with lung cancer

Moulas¹,

Gerogianni²,

Papadopoulos³

et al. 2006

Respirology

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 84%

See 1 more Smart Citation

Serum retinoic acid, retinol and retinyl palmitate levels in patients with lung cancer

Moulas¹,

Gerogianni²,

Papadopoulos³

et al. 2006

Respirology

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show abstract

“…By binding to RBP, TTR is thought to prevent glomerular filtration of the 21 kDa RBP. (2,5,51) TTR has also been suggested to play a direct role in the delivery of retinol to tissues. (2,5) The effects of TTR-deficiency on retinol and RBP metabolism were explored in a genetically engineered strain of mice (TTR À / À ) that totally lacks immunoreactive TTR.…”

Section: The Role Of Membrane-bound Retinol Dehydrogenasesmentioning

confidence: 99%

“…(2,5,51) TTR has also been suggested to play a direct role in the delivery of retinol to tissues. (2,5) The effects of TTR-deficiency on retinol and RBP metabolism were explored in a genetically engineered strain of mice (TTR À / À ) that totally lacks immunoreactive TTR. (1,52) The mice are healthy and fertile, and show no apparent develop-mental defects.…”

Section: The Role Of Membrane-bound Retinol Dehydrogenasesmentioning

confidence: 99%

Studies of vitamin A metabolism in mouse model systems

2001

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Over the past several years, discoveries from mouse genetics have had direct impact on our understanding of vitamin A metabolism. Although the metabolism of vitamin A in the mouse does have some special features (for example very large stores of liver and pulmonary retinyl esters), the ability to construct knockout and transgenic mouse models has yielded an impressive amount of information directly relevant to understanding the general principles of vitamin A transport, storage and degradation. We discuss below the metabolism of vitamin A through a number of genetically engineered mouse strains with alterations in genes that affect this metabolism. The novelty of this experimental approach is evidenced by the fact that the oldest of these strains was first reported only eight years ago.1)

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Retinol-Binding Protein-Deficient Mice: Biochemical Basis for Impaired Vision

et al. 2002

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We reported previously that mice lacking plasma retinol-binding protein (RBP) are phenotypically normal except that they display impaired vision at the time of weaning. This visual defect is associated with greatly diminished eyecup levels of retinaldehyde and is reversible if the mutants are maintained for several months on a vitamin A-sufficient diet. Here we provide a biochemical basis for the visual phenotype of RBP-deficient mice. This phenotype does not result from inadequate milk total retinol levels since these are not different for RBP-deficient and wild-type mice. The eye, unlike all other tissues that have been examined, takes up dietary retinol very poorly. Moreover, compared to other tissues, the eye displays a strong preference for retinol uptake when retinol is delivered bound to RBP. The poor uptake of dietary retinol by the eye coupled with its marked ability to take up retinol from RBP, we propose, provides a basis for the impaired vision observed in weanling RBP-deficient mice. Further study of the mutants suggests that the impaired vision is reversible because the eyes of mutant mice slowly acquire sufficient retinol from the low levels of retinol present in their circulation either bound to albumin or present in lipoprotein fractions. Thus, the eye is unlike other tissues in the body in that it shows a very marked preference for acquiring retinol needed to support vision from the retinol-RBP complex and is unable to meet adequately its retinol need through uptake of recently absorbed dietary retinol. This provides an explanation for the impaired vision phenotype of RBP-deficient mice.

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Factors affecting blood levels of vitamin A

Cited by 6 publications

References 103 publications

Serum retinoic acid, retinol and retinyl palmitate levels in patients with lung cancer

Serum retinoic acid, retinol and retinyl palmitate levels in patients with lung cancer

Studies of vitamin A metabolism in mouse model systems

Retinol-Binding Protein-Deficient Mice: Biochemical Basis for Impaired Vision

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