Abstract:This paper provides a detailed analysis to identify factors that improve bacterial targeting times to tumor microenvironments. We utilize the "active flagellar" motion characteristic of the bacterial movement to present a continuous time Markov model and a first passage time analysis to determine the factors that affect the mean time taken for injected bacteria to reach a tumor micro environment. We have determined 3 major factors that play a role in determining mean targeting times: (i) the population of the … Show more
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