Factors Affecting Amputations in Patients with Diabetic Foot Ulcer Referring To the Emergency Units

İçer, Mustafa; Durgun, Hasan Mansur

doi:10.5798/dicletip.298615

Cited by 5 publications

(2 citation statements)

References 19 publications

(28 reference statements)

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“…ulcers classification were the most common prevalence 30% in ulcers of diabetic patients, and these results were compatible with other studies conducted in different countries [13][14][15], but disagree with a previous study reported that Wagner's grade 2 and 3 ulcers were the most common prevalence [16]. Grade 4 was the lowest prevalence in this study, and this contrast with other studies revealed that the grade 4 was the most common prevalence in DFU [17,18]. Other studies showed the grade 4 was commonly infected with mixed variety of bacteria including extended spectrum beta-lactamase (ESBL) Klebsiella species and MRSA [17], also, highly multiple bacterial infection were more incidence in DFU grade 4 [19].…”

Section: Bacterial Species Of Dfu Associated With Wagner's Grades Systemcontrasting

confidence: 55%

Assessment role of phagocytic neutrophil cells among different Wagner’s grades of diabetic foot ulcers infections

Bin-Hameed¹,

Baras²

2020

Preprint

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Background: Foot ulcers complications in diabetes mellitus (DM) patients are one of the significant medical problems and an economic burden. The aim of this study is to assessment role of phagocytic neutrophil cells and its relationship with the incidence of diabetic foot ulcers (DFU) infection of diabetic patients. A total of 60 venipuncture blood samples collected from diabetes mellitus, diabetic foot ulcer patients and healthy persons as control group. 20 swabs from the DFU patients were collected and processed for culture and susceptibility test after the ulcers classified according to Wagner’s grades system. Phagocytic cells activity test was performed to determine the efficiency of phagocytic neutrophil cells in diabetic patients. Results: Gram positive bacteria were the most prevalent in the DFU patients 57.1% with statistical significant relationship between the type of bacteria and grades of Wagner’s classification followed by Gram negative bacteria in high grades of ulcers. Wagner’s ulcers grade 1 and 2 were the most prevalence in DFU patients 30%. There was a weak negative correlation between the efficiency of phagocytic neutrophil cells activity and grade ulcers classified (r = -0.323). Amikacin and ciprofloxacin were the most effective antibiotics against 90.5% and 81% of the bacterial isolates respectively, whereas ampicillin, cefepime and cefadroxil were less effective antibiotics against the bacterial isolates.Conclusion: When the grade of ulcer increased, the bacterial resistance to antibiotics increased, and this was emphasis the correlation with prevalent of Gram negative bacteria in the high grade of ulcers with high resistance of antibiotics. In contrast, the grade of ulcer increased, the efficiency of phagocytic neutrophil cells decreased.

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Section: Bacterial Species Of Dfu Associated With Wagner's Grades Systemcontrasting

confidence: 55%

Assessment role of phagocytic neutrophil cells among different Wagner’s grades of diabetic foot ulcers infections

Bin-Hameed¹,

Baras²

2020

Preprint

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“…11 The study conducted in Turkey revealed that 41.4% of diabetic patients with DFU underwent an amputation. 12 Moreover, DFU accelerates the mortality rate among diabetic patients, as shown by the retrospective cohort study conducted in Saudi Arabia stating deceased patients increased by almost 2-fold in diabetic patients with foot ulcers compared to diabetic patients without foot ulcers. 13 Similarly, a study from the UK also revealed a higher rate of mortality among DM patients with DFU compared to those without DFU.…”

Section: Introductionmentioning

confidence: 99%

<p>Determinants of Diabetic Foot Ulcer Among Adult Patients with Diabetes Attending the Diabetic Clinic in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: Unmatched Case–Control Study</p>

Woldemariam¹,

Tadele²,

Radie³

et al. 2020

DMSO

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Background: Diabetic foot ulcer is among the commonest complications of diabetic mellitus attributed to a number of morbidity and mortality cases in diabetic patients. Nowadays, the incidence of diabetic foot ulcer is increasing due to the increased prevalence of diabetes. However, the risk factors of the problem are less studied in Ethiopia. Hence, this study was conducted to assess the determinants of diabetic foot ulcer among adult patients with diabetes attending a diabetic clinic in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia in 2019. Patients and Methods: An institution-based unmatched case-control study was conducted on 161 patients with diabetes (53 patients with diabetes with foot ulcer and 108 patients with diabetes without foot ulcer). Cases were selected from patients with diabetes with foot ulcer by consecutive sampling technique and controls from patients with diabetes without diabetic foot ulcer by systematic random sampling technique. A binary logistic regression model was used to assess the association between the dependent and independent variables. All variables with a P-value<0.25 were included in the multivariable analysis. Statistical significance was declared at P-value<0.05 with 95% confidence interval. Results: In this study, 28 (52.8%) cases and 55 (50.9%) controls were male. Taking insulin alone (AOR=2.75, 95% CI=1.04-7.23), having peripheral neuropathy (AOR=7.56, 95% CI=2.82-20.24), not inspecting feet daily (AOR=5.61, 95% CI=2.24-14.05), and using moisturizing cream between toes (AOR=3.35, 95% CI=1.35-8.32) were positively associated with diabetic foot ulcer, whereas employed (AOR=0.35, 95% CI=0.14-0.87) and combined treatment (insulin and oral hypoglycemic agents) (AOR=0.11, 95% CI=0.02-0.57) were negatively associated with diabetic foot ulcer. Conclusion: Diabetic foot ulcer was significantly associated with occupation, kind of treatment of diabetes mellitus taking, peripheral neuropathy, inspecting feet daily, and putting moisturizing cream between toes. It will be helpful if diabetic patients inspect their feet on a daily basis and do not put moisturizing cream between their toes.

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Estimating The Efficiency Of Phagocytic Neutrophil Cells And Studying Its Risk Factors Among Diabetic Foot Ulcers

Baras

Hameed

2021

J. Phys.: Conf. Ser.

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There are several factors that affect the efficiency of phagocytic activity in diabetic patients. In this study, a significant difference of phagocytosis efficiency showed in diabetic patients and controls (non-diabetic). The means of phagocytic activity were 43.05%, 52.70% and 71.35% for diabetic foot ulcer, diabetes mellitus patients and controls respectively. Age groups, mean blood glucose levels and controlling fasting blood glucose were significant factors effects on phagocytic activity (P-value = 0.022, 0.013 and 0.045) respectively. There was reverse significant correlation between the mean blood glucose and phagocytic activity (P-value = 0.049; r =-0.314). Wagner grade ulcers classified I and II were the most prevalent 30% for both in diabetic foot ulcer patients. And we found that there is a weak negative correlation between the phagocytic activity efficiency and the grades of the classified ulcers (r =-0.323). In this study, we revealed that the efficiency of phagocytic activity was affected by many factors. Level of blood glucose control was the most important factor.

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Factors Affecting Amputations in Patients with Diabetic Foot Ulcer Referring To the Emergency Units

Cited by 5 publications

References 19 publications

Assessment role of phagocytic neutrophil cells among different Wagner’s grades of diabetic foot ulcers infections

Assessment role of phagocytic neutrophil cells among different Wagner’s grades of diabetic foot ulcers infections

<p>Determinants of Diabetic Foot Ulcer Among Adult Patients with Diabetes Attending the Diabetic Clinic in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: Unmatched Case–Control Study</p>

Estimating The Efficiency Of Phagocytic Neutrophil Cells And Studying Its Risk Factors Among Diabetic Foot Ulcers

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