Factors Affecting Adherence to Pharmacotherapy in Children with Attention-Deficit Hyperactivity Disorder: A Retrospective Study

Kim, Yoonjung; Oh, Seung Keun; Lee, Jiah; Moon, Su Jin; Lee, Won Hae; Bahn, Geon Ho

doi:10.5765/jkacap.2010.21.3.174

Cited by 7 publications

(11 citation statements)

References 17 publications

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“…Although the effectiveness of long-term use of psychostimulants has been shown to minimize developmental interference (Murray-Close et al, 2010) and lifelong problems, such as criminality, unemployment, and psychiatric comorbidity, a substantial portion of patients with ADHD remain untreated or sub-optimally treated (Froehlich et al, 2007). Many studies have shown variable and consistently disappointing compliance rates for medication and have demonstrated that the majority of treatment dropouts occurred within the first 6 months (Garbe et al, 2012; Y. J. Kim et al, 2010; Lawson, Johnsrud, Hodgkins, Sasané, & Crismon, 2012; Perwien, Hall, Swensen, & Swindle, 2004).…”

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confidence: 99%

“…J. Kim et al, 2010; Lawson, Johnsrud, Hodgkins, Sasané, & Crismon, 2012; Perwien, Hall, Swensen, & Swindle, 2004). In South Korea, studies have shown that only approximately 60% of patients complied with treatment for the first 6 to 12 months (Hwang, Kim, & Cho, 2004; Y. J. Kim et al, 2010).…”

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confidence: 99%

“…Therefore, it is very important to take into account factors affecting treatment persistence to enhance favorable long-term outcomes. Although several factors have been identified, including socioeconomic status, age, sex, severity, comorbidity, parental status, and attitude toward diagnosis and treatment, results across studies are variable (Brinkman & Epstein, 2011; Brinkman et al, 2009; Gadow, Nolan, Sverd, Sprafkin, & Schwartz, 2002; Gajria et al, 2014; Hwang et al, 2004; Jensen et al, 2007; Y. J. Kim et al, 2010; Lee et al, 2002; McCarthy et al, 2009; Perring, 1997; Rieppi et al, 2002; Thiruchelvam, Charach, & Schachar, 2001).…”

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confidence: 99%

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Comorbidity and Factors Affecting Treatment Non-Persistence in ADHD

Park

Kim

2015

J Atten Disord

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Comorbidity and Factors Affecting Treatment Non-Persistence in ADHD

Park

Kim

2015

J Atten Disord

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“…The possible explanation of these high early drop-outs might be lack of enough awareness among parents, children, and physicians. Kim et al ( 29 ) suggested parent educational program at or before initiation of pharmacotherapy might increase the long term treatment compliance. There was a positive correlation between the length before pharmacotherapy initiation after diagnosis of ADHD, and treatment compliance at 6-month after initiation of pharmacotherapy.…”

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confidence: 99%

Naturalistic Pharmacotherapy Compliance among Pediatric Patients with Attention Deficit/Hyperactivity Disorder: a Study Based on Three-Year Nationwide Data

et al. 2016

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We examined short- and long-term medication compliance among youth with attention-deficit hyperactivity disorder (ADHD), using data from the National Health Insurance database in Korea. Of the 5,699,202 6–14-year-old youth in 2008, we chose those with at least 1 medical claim containing an ICD-10 code for diagnosis of ADHD (F90.0) and no prescription for ADHD within the previous 365 days. We tracked the data every 6 months between 2008 and 2011, to determine treatment compliance among newly diagnosed, medicated patients. Further, we checked every 1 month of the 6 months after treatment commencement. Treatment continuity for each patient was calculated by sequentially counting the continuous prescriptions. For measuring compliance, we applied the medication possession ratio (MPR) as 0.6, 0.7, and 0.8, and the gap method as 15- and 30-days’ intervals. There were 15,133 subjects; 11,934 (78.86%) were boys. Overall 6-month treatment compliance was 59.0%, 47.3%, 39.9%, 34.1%, 28.6%, and 23.1%. Monthly drop-out rates within the first 6 months were 20.6%, 6.5%, 4.7%, 3.7%, 3.0%, and 2.5%, respectively. When applying MPR more strictly or shorter gap days, treatment compliance lessened. This is the first nationwide report on 36-month treatment compliance of the whole population of 6–14-year-olds with ADHD. We found the beginning of the treatment, especially the first month, to be a critical period in pharmacotherapy. These results also suggest the importance of setting appropriate treatment adherence standards for patients with ADHD, considering the chronic course of ADHD.

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“…It might be related with tradition in Korea. 23) Because of the residue of son-preference in Korean culture, the parents are more tolerant of hyperactivity in boys. At the same time, parents are very ardent about the education of their children.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Adults with Attention-Deficit Hyperactivity Disorder Depending on the Age of Being Diagnosed in Childhood and Adulthood: Based on Retrospective Review in One University Hospital

Cho

Lee

et al. 2017

J Korean Acad Child Adolesc Psychiatry

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Objectives:The study aimed to identify the characteristics of attention-deficit hyperactivity disorder (ADHD) that was not diagnosed in childhood or adolescence, but only in adulthood. Methods: The characteristics of patients diagnosed with ADHD in adulthood were compared with those of patients diagnosed in childhood were assessed via a retrospective review of the medical records at one university hospital from 2005 to 2013. If the age at which they were confirmed as having ADHD was less than 19 years old, they were grouped as childhood-diagnosed group (CD); if they were 19 years old or more, they were grouped as adulthood-diagnosed group (AD). Results: The CD and AD included 50 (46.3%) and 58 (53.7%) patients, respectively. Inattention was the most common symptom in both groups. Behavioral and emotional problems were the second most frequent symptoms in the CD and AD, respectively. The intelligent quotient was significantly higher in the AD than in the CD. The most common comorbidity was depression in the CD and personality disorder in the AD. The most common reason for visiting the hospital was referral by acquaintances in the CD and media coverage in the AD. Conclusion: Clinicians should put ADHD on the index of suspicion when they examine adults with various psychiatric symptoms, because the diagnosis of ADHD might have been missed in childhood and the symptoms of ADHD might have changed as they grew up.

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Factors Affecting Adherence to Pharmacotherapy in Children with Attention-Deficit Hyperactivity Disorder: A Retrospective Study

Cited by 7 publications

References 17 publications

Comorbidity and Factors Affecting Treatment Non-Persistence in ADHD

Comorbidity and Factors Affecting Treatment Non-Persistence in ADHD

Naturalistic Pharmacotherapy Compliance among Pediatric Patients with Attention Deficit/Hyperactivity Disorder: a Study Based on Three-Year Nationwide Data

Comparison of Adults with Attention-Deficit Hyperactivity Disorder Depending on the Age of Being Diagnosed in Childhood and Adulthood: Based on Retrospective Review in One University Hospital

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