.in 1 , rghosh47@yahoo.co.in 2 .Abstract. In modern as well as ancient ciphers of public key cryptography, substitution boxes find a permanent seat. Generation and cryptanalysis of 4-bit as well as 8-bit crypto S-boxes is of utmost importance in modern cryptography. In this paper, a detailed review of cryptographic properties of S-boxes has been illustrated. The generation of crypto S-boxes with 4-bit as well as 8-bit Boolean functions (BFs) and polynomials over Galois field GF(p q ) has also been of keen interest of this paper. The detailed analysis and comparison of generated 4-bit and 8-bit S-boxes with 4-bit as well as 8-bit S-boxes of Data Encryption Standard (DES) and Advance Encryption Standard (AES) respectively, has incorporated with example. Detailed analysis of generated Sboxes claims a better result than DES and AES in view of security of crypto S-boxes.