Factorial designed 5-fluorouracil-loaded microsponges and calcium pectinate beads plugged in hydroxypropyl methylcellulose capsules for colorectal cancer

Gupta, Ankita; Tiwari, Gaurav; Tiwari, Ruchi; Srivastava, Rishabh

doi:10.4103/2230-973x.167688

Cited by 31 publications

(20 citation statements)

References 19 publications

(19 reference statements)

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“…Lesion area and colorimetry measurements also were significantly improved at each visit (p < .001). The formulation was welltolerated and only one patient discontinued the study because of the occurrence of an allergic reaction, which was not found to be serious (Gupta, Tiwari, Tiwari, & Srivastava, 2015).…”

Section: Microsponges In Melanomamentioning

confidence: 99%

Microsponge: An emerging drug delivery strategy

Singhvi

Manchanda

Hans

et al. 2018

Drug Development Research

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Microsponges are the spherical particles ranging from 5 to 300 μm in size. These are further made up of clusters of smaller spheres. They are designed for delivering the drug efficiently at a comparatively lesser dose and enhancing the stability, modifying the drug release profile and minimizing the side effects. Microsponge drug delivery system decrease transdermal invasion of the active ingredient into the skin while increasing the time the drug remains on the skin surface or within the epidermis. Preparation of the microsponges includes two techniques: Liquid–liquid suspension polymerization and Quasi‐emulsion solvent diffusion method. Their characterization and evaluation can be done in many ways like particle‐size measurement and porosity, morphology, true density determination, analyzing the rheological properties, and dissolution studies. Present work focuses on the detailed study of the microsponge drug delivery system. This will help the reader to get all the information regarding the microsponge delivery systems.

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Section: Microsponges In Melanomamentioning

confidence: 99%

Microsponge: An emerging drug delivery strategy

Singhvi

Manchanda

Hans

et al. 2018

Drug Development Research

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“…MS may efficiently be taken up by the macrophages in the colon, thus showed effective localized drug action at the site of action [5]. These characteristics make MS more advantageous over many drug delivery systems such as microcapsules and liposomes [14][15][16].…”

Section: Determination Of Encapsulation Efficiency (Ee)mentioning

confidence: 99%

“…In such a way, increasing the dispersed phase viscosity resulted in increasing the particle size of microparticles (Table 2) [26][27][28]. 5-FU were prepared previously by another group as MS [39], using the technique W/O/W emulsification method. This method showed a good formulation but with lower% EE, which showed maximum% EE of about 59%.…”

Section: Drug Loaded Microspongesmentioning

confidence: 99%

“…However, intravenous administration leads to the quick distribution and elimination of 5-FU with an instant half-life of 8-20 minutes [5]. It was reported that 5-FU rapidly cleared from the plasma due to its rapid metabolism with a mean half-life 6.3 minutes and with regular peak plasma at 13.4 µg/mL.…”

Section: Introductionmentioning

confidence: 99%

“…Hence, the need to formulate targeted delivery of 5-FU through oral route would not only diminish the exposure of healthy cells to the drug but also provide an efficient and harmless curative effect for colon cancer with a lower dose and reduced duration of therapy [5]. It was reported that the therapeutic effect of 5-FU can be augmented and its harmful effects can be suppressed by the precise accumulation of the anticancer agent in the tumor regions with continued exposure of the cells to this drug [10].…”

Section: Introductionmentioning

confidence: 99%

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Preparation and Evaluation of 5-Fluorouracil Loaded Microsponges for Treatment of Colon Cancer

Othman¹,

Zayed²,

El‐Sokkary³

et al. 2017

J Cancer Sci Ther

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5-Fluorouracil (5-FU) has a wide anticancer activity versus several types of solid tumors. The activity of 5-FU can be improved and its toxicity can be diminished by enhancing the relative specific accumulation in the tumor regions. The aim of this work was to develop Eudragit RS100 based 5-FU microsponges (MS) for treatment of colon cancer. Oil in oil emulsion solvent diffusion method was used for the preparation of 5-FU sustained release Eudragit RS100 MS. MS were characterized for their encapsulation efficiency, production yield, drug polymer interaction and drug release profiles. Shape, surface morphology visualized by scanning electron microscope (SEM) and particle size of MS was investigated using laser light scattering technique and. Eventually, HCT 116 and CACO2 cell lines were used for determination of cell viability by MTT assay. The results showed that all prepared MS were spherical in shape with several pores on their surfaces. The production yield was in (62.76% ±1.06% and 93.80% ± 1.75%), encapsulation efficiency was in (71.80% ± 1.62% and 101.3% ± 2.60%) and particle size was in ( 53.11 µm ± 41.03 nm and 118.12 µm ± 48.21 nm). Fourier transform infrared revealed that there is no chemical interaction between 5-FU and Eudragit RS100. MS loaded 5-FU was more effective than 5-FU itself as shown by cell viability assay. The results demonstrated that 5-FU with Eudragit RS100 was successfully formulated as sustained release manner and could be a substitution delivery method of 5-FU for oral anticancer treatment.represent an important factor to oral as compared to administration intravenously as reported previously [9].Conversely, intravenous administration of 5-FU yields severe systemic toxic effects of gastrointestinal (GIT), blood complaints, and skin diseases, due to the 5-FU cytotoxicity on healthful human cells. Hence, the need to formulate targeted delivery of 5-FU through oral route would not only diminish the exposure of healthy cells to the drug but also provide an efficient and harmless curative effect for colon cancer with a lower dose and reduced duration of therapy [5]. It was reported that the therapeutic effect of 5-FU can be augmented and its harmful effects can be suppressed by the precise accumulation of the anticancer agent in the tumor regions with continued exposure of the cells to this drug [10]. To extend the exposure time of cancer cells to 5-FU, the drug delivery was formulated by incorporation into microsponge formulation.Microsponges (MS) are micro-sized particles with high porosity and unique ability for encapsulation of a wide multiplicity of pharmaceutical active ingredients. MS delivery system is used to target and modify the release of active ingredients from pharmaceutical formulations, enhance the stability and decrease the side effects [11]. MS have high load activity reach up to 90% entrapment efficiency [12], self-sterilizing Citation: Othman MH, Zayed GM, El-Sokkary GH, Ali UF, Abdellatif AAH (2017) Preparation and Evaluation of 5-Fluorouracil Loaded Microsp...

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Edible and Nutritive Electronics: Materials, Fabrications, Components, and Applications

Shan

et al. 2020

Adv Materials Technologies

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In comparison with the implantable electronics, ingestible electronics are less invasive but can travel close to major organs through the gastrointestinal (GI) tract, monitor a wide range of biomarkers and therapeutic targets, and serve as effective clinical tools for diagnostics and therapy. [4d,5] Today, GI conditions have become one of the most prevalent health concerns in modern society. The market was expected to nearly reach the one-billion-dollar mark. [4e] Through analyzing the conditions of the GI tract [4d] (Figure 1), many diseases can be monitored and diagnosed, e.g., refluxing gastric fluid, cancer, motility disorders, infected and abnormally dilated venous vessels, gastritis, gastric ulcers, coeliac disease, lactose intolerance, Crohn's disease, inflammatory bowel disease, diverticular disease, constipation, clostridium difficile-associated diarrhea, irritable bowel syndrome, etc. [5,6] Conventional ingestible electronics mostly consist of inorganic materials and encapsulated with rigid nondegradable polymer, such as polydimethylsiloxane, parylene/epoxy, [4a] which will lead longer devices retention in the GI tract. This is one of the most significant risk elements during the application of conventional ingestible electronics. Fully food-based edible and nutritive electronics have emerged to address these potential risks. Edible electronics are new generation ingestible electronics. Recently, there is no accurate and clear definition of edible electronics. [4g,7] The definition of "transient electronics," [3h] which focused on implantable electronics, was similar to the edible electronics concept and defined as: made of biodegradable materials and can completely or partially dissolve, resorb, or physically disappear after functioning in environmental or physiological conditions at controlled rates. By follow this spirit, the definition of edible electronics is provided here: a class of microencapsulated electronic devices that consist of edible and nutritive inorganics and organics materials, meanwhile, that can be mainly dissolved, digested and absorbed after fulfilling the diagnosis or therapy of diseases in the gastrointestinal tract. The edible and nutritive inorganics always include edible inert metals, trace elements [8] and their oxides. Nutritive organics always include biopigments, and polymers. [7,9] A more systemic and expanded materials toolbox will be very helpful to advance The emerging novel edible and nutritive electronics indicate an important advance in ingestible and implantable electronics, covering multiple disciplines such as biomedicine, electronics, and nutriology. This review focuses on the feasibility and critical technical problems of fabricating fully edible and nutritive electronics. Recently, a limited number of fully edible and nutritive electronics, operating single functions, have been applied to monitor the condition of the gastrointestinal (GI) tract and diagnose its disorders. However, fully edible, nutritive, miniaturized, and well-functioning electronics with mu...

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Factorial designed 5-fluorouracil-loaded microsponges and calcium pectinate beads plugged in hydroxypropyl methylcellulose capsules for colorectal cancer

Cited by 31 publications

References 19 publications

Microsponge: An emerging drug delivery strategy

Microsponge: An emerging drug delivery strategy

Preparation and Evaluation of 5-Fluorouracil Loaded Microsponges for Treatment of Colon Cancer

Edible and Nutritive Electronics: Materials, Fabrications, Components, and Applications

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