Factorial design formulation optimization and in vitro characterization of curcumin-loaded PLGA nanoparticles for colon delivery

Complexation of curcumin with whey protein isolate for enhancing its aqueous solubility through a solvent‐free pH‐driven approach

“…The in vitro curcumin release behavior under simulated gastrointestinal conditions was evaluated with a dialysis sac method (Akl et al, ). For this purpose, the pH of curcumin‐WPI complex which was produced by pH shifting method was adjusted to 1.2.…”

“…This bioactive molecule has a variety of beneficial biological functions, such as antioxidant, anticancer, anti‐inflammatory, and antibacterial properties (Tapal & Tiku, ; Medina‐Torres et al, ). It was also reported that curcumin can prevent Alzheimer's disease, diabetes, and atherosclerosis (Akl et al, ). However, the applications of curcumin as a biologically active compound in different functional foods and beverages have been limited due to its extremely low water solubility, low chemical stability, poor oral bioavailability, and rapid metabolism (Tapal & Tiku, ).…”

Freeze-dried eudragit-hyaluronan multicompartment liposomes to improve the intestinal bioavailability of curcumin

“…The oral administration of curcumin in innovative carriers represents the most attractive strategy, because it can ensure local delivery and accumulation in the intestines, and improve the systemic biovailability at the same time [11,12]. Nanoparticulate systems are promising tools for oral delivery of low bioavailable compounds, when properly designed [13][14][15]. Among the different nanosystems, liposomes have been widely employed due to their safety and versatility.…”

Recent insights into nanotechnology development for detection and treatment of colorectal cancer

“…For instance, curcumin-loaded PLGA NPs for colon delivery were successfully prepared using the emulsion-solvent evaporation technique. 49 The use of the 2 3 factorial design model enabled the development of an optimized curcumin-loaded PLGA-based nanoformulation using minimal raw material in a short time. Studies based on differential scanning calorimetry confirmed the presence of curcumin in an amorphous or disordered crystalline phase of molecular dispersion form or in a solid solution state in the polymer matrix.…”

“…The smaller size, sustained release, better colloidal stability in synthetic gastrointestinal fluids, long-term stability, and a considerably higher cellular uptake in HT-29 cells as compared with those of pure curcumin solution indicate that the optimized curcumin-loaded PLGA NP formulation (C-PNP 9 ) has high potential as an initial platform for the further development of an efficient oral targeted drug-delivery system to the colon, especially if it is further functionalized with a mucoadhesive polymer or a specific targeting ligand. 49 In another study, researchers prepared chitosan polymeric NPs by the solvent evaporation emulsification method, with varied ratios of polymer. 50 They concluded that the NPs prepared by solvent evaporation emulsification using the polymer at the optimum ratio represents an approach for potentially successful delivery of the active pharmaceutical element to the colorectal tumors.…”