Factorial design approach to microwave dissolution

Mohd, Amran Ali; Dean, John R.; Tomlinson, W. R.

doi:10.1039/an9921701743

Cited by 24 publications

(13 citation statements)

References 9 publications

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“…7, 2011 less ambiguous data. 27 The application of experimental design for optimizing the dissolution test is a valuable tool for reducing the amount of work needed for formulation and test development. In fact, the factorial design makes possible the reduction of the number of single experiments and the improvement of the method reliability.…”

Section: Resultsmentioning

confidence: 99%

Optimization of a new dissolution test for oxcarbazepine capsules using mixed-level factorial design

Polonini¹,

Oliveira²,

Ferreira³

et al. 2011

J. Braz. Chem. Soc.

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Neste trabalho foi desenvolvido e validado um teste de dissolução para cápsulas de oxcarbazepina. Para o estudo de triagem, foi utilizado um planejamento experimental de níveis mistos composto de fatores com dois e três níveis (3 2 × 2), de modo a selecionar a velocidade de agitação, o meio de dissolução e o aparato. Esta estratégia é útil, pois reduz o tempo de desenvolvimento do método e também gera resultados mais exatos. A melhor porcentagem de dissolução foi obtida utilizando o aparato pá a 80 rpm e com solução aquosa de laurilsulfato de sódio a 1% m/v como meio de dissolução. A quantificação da massa dissolvida foi realizada por análise espectrofotométrica UV-Vis a 304 nm. Os resultados do estudo da validação demonstraram que o método é preciso e linear no intervalo de 83-249 μg mL -1 de oxcarbazepina. Os resultados evidenciaram que o método apresenta utilidade e adequabilidade para o estudo da dissolução de cápsulas de oxcarbazepina, uma vez que não existe método oficial com este propósito.In this work, a dissolution test for oxcarbazepine capsules was developed and validated. For the screening study, a mixed-level factorial design containing factors at three and two levels (3 2 × 2) was used in order to select the stirring speed, the dissolution medium and the dissolution apparatus. This strategy is needful for reducing the time of method development and to provide less ambiguous data. The best in vitro percentage dissolution was obtained using apparatus paddle at 80 rpm and sodium lauryl sulfate 1% m/v aqueous solution as the dissolution medium. The quantification of the mass dissolved was obtained by UV-Vis spectrophotometric analysis at 304 nm. The validation results demonstrate that the method was precise and linear over the range of 83-249 μg mL -1 of oxcarbazepine. Thus, the method is useful and adequate for oxcarbazepine capsules dissolution test, once there is no official monograph regarding it. Keywords: oxcarbazepine, dissolution test, mixed-level factorial design IntroductionOxcarbazepine (OCBZ) (Figure 1) is a keto analog of carbamazepine 1 indicated as monotherapy or adjunctive therapy for the treatment of partial seizures with or without secondarily generalized tonic-clonic seizures in adults and children aged over six years. 2,3 The advantages of OCBZ on carbamazepine are: lower frequency and severity of adverse events (particularly endocrine), [4][5][6] better tolerability, 3,6 fewer drug interactions 7 and almost complete absorption after oral ingestion. 3 Another point is that OCBZ is a low therapeutic index, high dosage and low potency drug. Its compounding and marketing, therefore, can only be made if the performance of the formulation is proved by conducting the dissolution test of the final product. Optimization of a New Dissolution Test for Oxcarbazepine Capsules J. Braz. Chem. Soc. 1264 Dissolution tests have become a highly valuable tool for quality analysis in the pharmaceutical industry in what concerns the performance of the oral solid dosage form/delivery system, 9,10 bec...

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Section: Resultsmentioning

confidence: 99%

Optimization of a new dissolution test for oxcarbazepine capsules using mixed-level factorial design

Polonini¹,

Oliveira²,

Ferreira³

et al. 2011

J. Braz. Chem. Soc.

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“…[23] have determined that the efficiency of microwave digestion is affected by several parameters which need to be optimized. These include the amount of sample to be used, the type and amount of acid used, the microwave power applied, and the time of dissolution.…”

Section: Effect Of Acid Mixturementioning

confidence: 99%

Inorganic and methyl-mercury speciation in sediments of the Swarzędzkie Lake

Barałkiewicz

Gramowska

Gołdyn

et al. 2007

Chemistry and Ecology

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Sediment samples were analysed for mercury and methylmercury content in different parts of the bottom sediment of Swarzędzkie Lake, which were influenced by different external pollution sources. The results of determination with two methods of mineralization using two separate media (HNO 3 /H 2 O 2 and HF) were compared. The accuracy of the studied methods was analysed using certified reference material IAEA 405 of river sediment. The recovery of mercury was satisfactory and ranged from 97.5 to 98.8%. Methylmercury compounds in the studied sediments were found in limited concentrations. Their concentrations ranged from 0.26 to 58.1 μg kg −1 , i.e. 1.0-7.4% of the total mercury content. The depth profile displayed high values of both total and methylmercury content at a depth of 10-20 cm, related to the heavy pollution of the lake in the 1980s. Canonical analysis displayed the relationship of both total mercury and methylmercury concentrations with organic matter and phosphorus content in bottom sediments.

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“…Use of such a technique for acid digestion has greatly reduced the time of preparations as well as the risks pointed out by classical methods. Despite these advantages, very few studies have provided guidelines for choosing the best operating conditions (1)(2)(3).…”

Section: Introductionmentioning

confidence: 99%