Factorial design approach to evaluate interactions between electrically assisted enhancement and skin stripping for delivery of tacrine

Potential of iontophoresis as a drug delivery method for midazolam in pediatrics

“…TEWL matures rapidly with postnatal age [22]; for example, the TEWL in 78 neonates achieved maturation values 2 to 3 weeks after birth and independently of their GA (26-41 weeks). The approach used in our work has been previously described [28,[53][54][55][56][57][58][59] and, as before [24,54,58,59], an empirical, exponential relationship between both passive and iontophoretic drug fluxes and the degree of skin barrier competency (assessed by TEWL) was found (Figure 6). The results in Figure 5 show that iontophoresis was clearly controlling drug delivery across intact and half-compromised skin, the most relevant range of barrier competence.…”

In vitro transdermal iontophoretic delivery of penbutolol sulfate

“…However, postiontophoretic flux was lower than iontophoretic flux. It is possible that a penbutolol depot was formed in the skin (Hirsch, Upasani, and Banga 2005).…”

Advances in Transdermal Delivery of Antimicrobial Peptides for Wound Management: Biomaterial-Based Approaches and Future Perspectives

“…Furthermore, localized and targeted drug delivery via iontophoresis minimizes systemic side effects and drug interactions, which can be particularly crucial in cases in which antimicrobial agents may be toxic to normal cells. The potential of this technique to create an acidic environment at the cathode or an alkaline environment at the anode may also enhance the antimicrobial activity of the peptides …”