Factorial Analysis of the Cardiometabolic Risk Influence on Redox Status Components in Adult Population

Klisić, Aleksandra; Kavarić, Nebojša; Vujčić, Sanja; Spasojević‐Kalimanovska, Vesna; Kotur‐Stevuljević, Jelena; Ninić, Ana

doi:10.1155/2021/6661940

Cited by 18 publications

(24 citation statements)

References 35 publications

(46 reference statements)

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“…32 , 33 As we all know, chronic inflammation and oxidative stress are involved in the development of DR. Recent studies have shown the relationship between LAP, oxidative stress, 34 and inflammation. 35 In conclusion, LAP may be closely related to chronic inflammation, cardiovascular diseases, diabetes, and complications.…”

Section: Discussionmentioning

confidence: 99%

Association Among Lipid Accumulation Product, Chinese Visceral Obesity Index and Diabetic Retinopathy in Patients with Type 2 Diabetes: A Cross-Sectional Study

Li¹,

Li²,

Yu³

et al. 2021

DMSO

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Background and Aim Obesity often coexists with diabetes, especially abdominal obesity, recognized as a risk factor for diabetic complications. Diabetic retinopathy (DR), as one of the most common microvascular complications of diabetes, may be associated with these indices. Lipid accumulation product (LAP) and Chinese visceral obesity index (CVAI) are novel visceral obesity indicators, which have been proven to be an influential factor predicting type 2 diabetes (T2DM). However, the correlation among LAP, CVAI, and DR still lacks systematic research in T2DM. The study aimed to explore the relationship among LAP, CVAI levels in different DR stages of T2DM patients and the diagnostic efficacy of LAP and CVAI for DR. Methods A total of 263 participants were recruited in this cross-sectional study. We enrolled 169 patients with T2DM, divided into the non-DR group (NDR, n = 61), non-proliferative DR group (NPDR, n = 55), and proliferative DR group (PDR, n = 53). And we also enrolled 94 healthy control participants. We collected demographic, anthropometric, and biochemical data on each subject. LAP and CVAI are calculated according to different formulas for men and women. Results Compared with the control group, LAP and CVAI were significantly higher (P < 0.05). After adjusting for confounding factors, LAP (OR: 1.029, 95CI%: 1.010–1.049, P < 0.05), WC (OR: 1.073, 95CI%: 1.009–1.141, P < 0.05) and CVAI (OR: 1.017, 95CI%: 1.000–1.033, P < 0.05) were all associated with an increased risk of DR. Furthermore, increased LAP (OR: 1.020, 95% CI: 0.100–0.290) is associated with DR severity (P < 0.001). Moreover, the LAP had the most significant area under the receiver operating characteristics (ROC) curve (AUC) (AUC = 0.728, 95% CI: 0.653–0.804). Conclusion A high LAP is associated with an increased risk of DR in T2DM patients, and the LAP index appears to be a good predictor of DR risk and severity in patients with T2DM, compared with BMI, WC, and CVAI.

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Section: Discussionmentioning

confidence: 99%

Association Among Lipid Accumulation Product, Chinese Visceral Obesity Index and Diabetic Retinopathy in Patients with Type 2 Diabetes: A Cross-Sectional Study

Li¹,

Li²,

Yu³

et al. 2021

DMSO

View full text Add to dashboard Cite

show abstract

“…Only a few studies have examined the clustering pattern of established cardiometabolic risk factors (e.g., lipid, adiposity, blood pressure, sedentary lifestyle, etc.) and the joint influence of unfavorable cardiometabolic profile in non-psychiatric populations ( Stoner et al., 2017 ; Tsai et al., 2020 ; Klisic et al., 2021 ). No previous work has examined the aggregation of genetic risks for multiple cardiometabolic traits in psychiatric populations.…”

Section: Discussionmentioning

confidence: 99%

Inflammation subtypes in psychosis and their relationships with genetic risk for psychiatric and cardiometabolic disorders

Zhang

Lizano

Guo

et al. 2022

Brain, Behavior, & Immunity - Health

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“…We were also limited for determination of lipid metabolism parameters which may affect the results of the study [ 29 , 30 ]. Moreover, we were not able to exclude type 2 diabetes, smoking, and medications other than immunosuppressive drugs and dietary supplements, which all might affect the results of the study.…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress in Patients before and after On‐Pump and Off‐Pump Coronary Artery Bypass Grafting: Relationship with Syntax Score

Vukićević

Klisić

Nešković

et al. 2021

Oxidative Medicine and Cellular Longevity

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Objective. Coronary artery bypass grafting (CABG) represents the significant source of increased oxidative stress (OS). We aimed to follow the OS status parameters (i.e., ischemia-modified albumin (IMA), malondialdehyde (MDA), superoxide anion, prooxidant-antioxidant balance (PAB), total oxidant status (TOS), total antioxidant status (TAS), and superoxide-dismutase (SOD)) change through the predefined study times in two different surgical procedures, i.e., cardiopulmonary bypass (CPB) and off-pump coronary artery bypass grafting (OPCAB). Additionally, we aimed to investigate those OS status parameters in specific study times according to SYNTAX score (SS), an established angiographic score for evaluating the extensity and severity of coronary artery disease. Patients and Methods. A total of 107 patients that were planned to undergo CABG were included (i.e., 47 patients in OPCAB and 60 patients in CPB group). Blood samples were taken at 6 time intervals: before surgery (t1), immediately after intervention (t2), 6 h (t3), 24 h (t4), 48 h (t5), and 96 h after termination of the operation (t6). Results. IMA levels were higher in CPB than that in OPCAB baseline and rose in CPB group in t2 point. TOS decreased in both study groups, compared to baseline values, but without statistical significance. Superoxide anion and PAB significantly increased in t3-t6 study times, in both groups. MDA significantly increased only in CPB group in t5 and t6 interval. MDA was significantly higher in CPB group compared to OPCAB in t6 study point. CPB patients had significantly lower TAS compared to OPCAB patients at the beginning and in t2 and t3 study points. They also had significantly lower SOD activities compared to OPCAB, baseline, and in several study points. Moreover, TAS, SOD, and TAS/TOS ratio were significantly lower, whereas PAB and TOS/TAS were significantly higher in patients with high SS compared to corresponding groups. SOD activity, IMA, and TAS level were the best predictors of high SS. Conclusion. CPB patients were in more severe ischemia baseline than OPCAB group and IMA rose in CPB patients immediately after the surgery end, but not later. Also, the antioxidant status was significantly lower, whereas the prooxidant status was significantly higher in patients with high SS compared to corresponding groups. SOD activity, IMA, and TAS level were the best predictors of CAD (as determined with SS), showing that SOD and IMA had very good discriminatory capability towards higher SS status.

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Factorial Analysis of the Cardiometabolic Risk Influence on Redox Status Components in Adult Population

Cited by 18 publications

References 35 publications

Association Among Lipid Accumulation Product, Chinese Visceral Obesity Index and Diabetic Retinopathy in Patients with Type 2 Diabetes: A Cross-Sectional Study

Association Among Lipid Accumulation Product, Chinese Visceral Obesity Index and Diabetic Retinopathy in Patients with Type 2 Diabetes: A Cross-Sectional Study

Inflammation subtypes in psychosis and their relationships with genetic risk for psychiatric and cardiometabolic disorders

Oxidative Stress in Patients before and after On‐Pump and Off‐Pump Coronary Artery Bypass Grafting: Relationship with Syntax Score

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